HPE DL110 Gen12 vs Lenovo SE455 V3
A specification-by-specification comparison of the HPE ProLiant Compute DL110 Gen12 and the Lenovo ThinkEdge SE455 V3, built from HPE’s and Lenovo’s own documents. 1 headline measure favours the DL110 Gen12, 5 favour the SE455 V3, and they share no processors.
Bottom line. DL110 Gen12 leads on network throughput. SE455 V3 leads on virtualisation, databases and in-memory work, storage density, AI and acceleration. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.
The measures that decide it
Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.
Which one, and why
Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.
Choose the DL110 Gen12 if…
- Fastest network option: 400 GbE class against 200 GbE class on the SE455 V3
- Eight 25GbE ports are integrated on the board, and HPE’s overview quotes support for up to 20 10/25GbE ports in all.
Choose the SE455 V3 if…
- Cores, fully populated: 64 against 40 on the DL110 Gen12
- Memory ceiling: 0.75 TB against 0.5 TB on the DL110 Gen12
- Drive bays: 8 against 0 on the DL110 Gen12
- At 440 mm deep, with rail kits for two-post, 600 mm and 1000 mm racks, it is shorter than a conventional rack server and built for tight spaces.
Where each one pulls ahead
Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.
Side by side, differences first
Everything both documents state, grouped. The default view hides rows where the two machines are identical.
Processors
Every processor each vendor lists for the model, from its own document.
| Specification | DL110 Gen12 | SE455 V3 |
|---|---|---|
| Processors listed | 1 | 12 |
| Most cores per processor | 40 | 64 |
| Highest processor TDP | 235 W | 200 W |
| Processor families | Xeon 6 P-core | AMD EPYC 8004 |
Memory
| Specification | DL110 Gen12 | SE455 V3 |
|---|---|---|
| DIMM slots | 4 | 6 |
| Slots per processor | 4 | 6 |
| Fastest rated speed | 6,400 MT/s | 4,800 MT/s |
| Memory types | RDIMM DDR5-6400 (HPE DDR5 Smart Memory, Registered) | RDIMM DDR5-4800 (10x4 RDIMM, x8 RDIMM; 128GB 5600 runs at 4800) |
Storage
Bay counts are the maximum each document states, including rear and mid-chassis positions.
| Specification | DL110 Gen12 | SE455 V3 |
|---|---|---|
| Maximum bays | 0 | 8 |
| Documented layouts | 0 | 4 |
| Bay sizes | — | 2.5-inch |
| Boot devices | HPE 480GB NVMe Gen4 Mainstream Performance Read Intensive M.2 2280 PE9010 SSD · HPE 960GB NVMe Gen4 Mainstream Performance Read Intensive M.2 2280 PE9010 SSD · HPE 960GB NVMe Gen4 Mainstream Performance Read Intensive M.2 2280 Self-encrypting PE9010 SSD + 1 more | ThinkSystem M.2 SATA/x4 NVMe 2-Bay Adapter (BVUY) - NVMe via onboard port; SATA only with RAID 5350-8i; RAID via separate adapter (5350-8i SATA / 540-8i NVMe) · ThinkSystem M.2 RAID B540i-2i SATA/NVMe Adapter (BZPA) - integrated Broadcom RAID 0/1 |
| Storage controllers | 3 | 5 |
Accelerators & I/O
| Specification | DL110 Gen12 | SE455 V3 |
|---|---|---|
| Accelerators supported | Up to 2 | Up to 6 |
| Double-wide cards listed | 0 | 1 |
| OCP slots | 2 | 1 |
| PCIe network slots | 2 | 6 |
| Network cards listed | 16 | 26 |
Power & platform
| Specification | DL110 Gen12 | SE455 V3 |
|---|---|---|
| Power-supply options | 2 | 4 |
| Output range | 1,000–1,300 W | 1,100–1,800 W |
| Management | HPE iLO 7 | XClarity Controller 2 |
| Chassis depthVendors measure depth differently — see each data sheet | Short-depth: Overview/Platform Information prints '1U rack, reverse airflow system (front to rear) with 17" depth'. Technical Specifications System Unit dimensions (H x W x D) are 4.29 x 43.46 x 47.28 cm / 1.69 x 17.11 x 18.61 in, i.e. a printed depth of 47.28 cm (18.61 in) - see notes for this contradiction. | 440 mm (438 mm from the EIA flange) |
Processors, memory, bays and power
The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.
DL110 Gen12: processors by cores and TDP
SE455 V3: processors by cores and TDP
DL110 Gen12: memory with every slot filled
SE455 V3: memory with every slot filled
DL110 Gen12: drive bays
2 x M.2 NVMe SSD (3.84 TB max = 2 x 1.92 TB); no SFF/LFF hot-plug bays
SE455 V3: drive bays
Front panel
4 × 2.5" NVMe at the front — 4 bays in total.
DL110 Gen12: power supplies
SE455 V3: power supplies
DL110 Gen12 vs SE455 V3, answered
Is the DL110 Gen12 or the SE455 V3 the faster server?
Neither document publishes benchmark results, so this page compares what they do state. The DL110 Gen12 lists 1 processors up to 40 cores at 235 W; the SE455 V3 lists 12 up to 64 cores at 200 W. Fully populated that is 40 cores against 64.
Which holds more memory?
The DL110 Gen12 has 4 DIMM slots and a stated ceiling of 512 GB. The SE455 V3 has 6 and 768 GB.
Which takes more drives?
DL110 Gen12: 0 bays across 0 documented layouts. SE455 V3: 8 across 4. Counts include rear and mid-chassis positions where the vendor documents them.
Can either take GPUs?
DL110 Gen12: up to 2 accelerators, 0 double-wide cards listed. SE455 V3: up to 6, 1 double-wide listed.
Do they share any processors?
No. The two documents list different processors, so a like-for-like processor build is not possible across these two.
Where these figures come from. DL110 Gen12: HPE ProLiant Compute DL110 Gen12 QuickSpecs (Version 3 - April 6, 2026) (HPE document). SE455 V3: Lenovo ThinkEdge SE455 V3 and SE455i V3 Servers Product Guide (no revision date printed in text (related-publication timestamps run to 2026-07-14)) (Lenovo document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.
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