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Head-to-head · every figure from the vendor documents

HPE DL365 Gen11 vs Lenovo SR645 V3

A specification-by-specification comparison of the HPE ProLiant DL365 Gen11 and the Lenovo ThinkSystem SR645 V3, built from HPE’s and Lenovo’s own documents. 3 headline measures favour the DL365 Gen11, 1 favours the SR645 V3, and 40 processors appear in both lists.

Bottom line. DL365 Gen11 leads on storage density, network throughput. SR645 V3 leads on AI and acceleration. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.

HPE ProLiant DL365 Gen11 1U front with the HPE bezel fitted and the ProLiant DL365 Gen11 badge beside the status LEDs on the right ear
HPE ProLiant
DL365 Gen11
1U Rack2 sockets24 DIMMHPE iLO 6
Configure the DL365 Gen11 →Full data sheet
VS
Lenovo ThinkSystem SR645 V3 1U front with ten 2.5-inch hot-swap drive bays, two front USB ports, a VGA port and the model label
Lenovo ThinkSystem
SR645 V3
1U Rack2 sockets24 DIMMXClarity Controller 2
Configure the SR645 V3 →Full data sheet
01 — Scoreboard

The measures that decide it

Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.

2
Processor sockets
2
320
Cores, fully populated
Largest listed processor × its socket count
320
6 TB
Memory ceiling
As each document states it
6 TB
20Higher
Drive bays
16
Up to 2
Accelerators
HigherUp to 5
2,200 WHigher
Largest power supply
1,800 W
1U Rack
Rack height
1U Rack
400 GbE classHigher
Fastest network option
200 GbE class
02 — Verdict

Which one, and why

Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.

Choose the DL365 Gen11 if…

  • Drive bays: 20 against 16 on the SR645 V3
  • Largest power supply: 2,200 W against 1,800 W on the SR645 V3
  • Fastest network option: 400 GbE class against 200 GbE class on the SR645 V3
  • Two EPYC sockets in one rack unit: up to 320 cores and 24 DDR5 slots (6 TB), with 160 PCIe 5.0 lanes across the pair.

Choose the SR645 V3 if…

  • Accelerators: Up to 5 against Up to 2 on the DL365 Gen11
  • Two EPYC sockets in one rack unit: a pair of 160-core 9845s gives 320 cores, and each processor drives its own 12 DDR5 channels.
03 — By workload

Where each one pulls ahead

Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.

VirtualisationDL365 Gen11: 320 cores with 6 TB. SR645 V3: 320 cores with 6 TB.Line ball
Databases & in-memoryMemory ceiling 6 TB against 6 TB, across 24 and 24 DIMM slots.Line ball
Storage density20 bays in 1U against 16 in 1U.DL365 Gen11
AI & acceleration2 accelerators against 5 in the vendor documents.SR645 V3
Network throughputFastest card listed: 400 GbE class against 200 GbE class.DL365 Gen11
04 — Specifications

Side by side, differences first

Everything both documents state, grouped. The default view hides rows where the two machines are identical.

Processors

Every processor each vendor lists for the model, from its own document.

SpecificationDL365 Gen11SR645 V3
Processors listed4046

Memory

SpecificationDL365 Gen11SR645 V3
Memory typesRDIMM DDR5-4800 · RDIMM DDR5-6400 · RDIMM 3DS DDR5-4800 · RDIMM 3DS DDR5-6400RDIMM DDR5-6400 (5th Gen EPYC) · RDIMM DDR5-4800 (4th Gen EPYC) · 9x4 RDIMM · 3DS RDIMM DDR5-6400

Storage

Bay counts are the maximum each document states, including rear and mid-chassis positions.

SpecificationDL365 Gen11SR645 V3
Maximum bays2016
Documented layouts719
Bay sizes2.5-inch · E3.S3.5-inch · E3.S · 2.5-inch
Boot devicesHPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device + 2 moreM.2 SATA/NVMe 2-Bay Enablement Kit (4Y37A09738) · M.2 SATA/x4 NVMe 2-Bay Adapter (4Y37A79663) · M.2 NVMe 2-Bay RAID Adapter (4Y37A09750) + 1 more
Storage controllers1118

Accelerators & I/O

SpecificationDL365 Gen11SR645 V3
Accelerators supportedUp to 2Up to 5
OCP slots21
PCIe network slots25
Network cards listed4030

Power & platform

SpecificationDL365 Gen11SR645 V3
Power-supply options58
Output range800–2,200 W750–1,800 W
Input typesAC · 277 VAC / HVDCAC · −48 V DC
ManagementHPE iLO 6XClarity Controller 2
Chassis depthVendors measure depth differently — see each data sheetSFF 64.94 cm (25.57 in)—
05 — The data

Processors, memory, bays and power

The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.

DL365 Gen11: processors by cores and TDP

HPE ProLiant DL365 Gen11 processors081624324048566472808896104112120128136144152160100 W150 W200 W250 W300 W350 W400 WCores per processorAMD EPYC 9845 — 160 cores · 390 W · 2.1 GHz base · 320 MB cache · DDR5-6400AMD EPYC 9825 — 144 cores · 390 W · 2.2 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9745 — 128 cores · 400 W · 2.4 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9655 — 96 cores · 400 W · 2.6 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9645 — 96 cores · 320 W · 2.3 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9565 — 72 cores · 400 W · 3.15 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9575F — 64 cores · 400 W · 3.3 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9555 — 64 cores · 360 W · 3.2 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9535 — 64 cores · 300 W · 2.4 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9475F — 48 cores · 400 W · 3.65 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9455 — 48 cores · 300 W · 3.15 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9365 — 36 cores · 300 W · 3.4 GHz base · 192 MB cache · DDR5-6400AMD EPYC 9375F — 32 cores · 320 W · 3.8 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9355 — 32 cores · 280 W · 3.55 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9335 — 32 cores · 210 W · 3 GHz base · 128 MB cache · DDR5-6400AMD EPYC 9275F — 24 cores · 320 W · 4.1 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9255 — 24 cores · 200 W · 3.2 GHz base · 128 MB cache · DDR5-6400AMD EPYC 9175F — 16 cores · 320 W · 4.2 GHz base · 512 MB cache · DDR5-6400AMD EPYC 9135 — 16 cores · 200 W · 3.65 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9115 — 16 cores · 125 W · 2.6 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9015 — 8 cores · 125 W · 3.6 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9754 — 128 cores · 360 W · 2.25 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9734 — 112 cores · 340 W · 2.2 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9684X — 96 cores · 400 W · 2.55 GHz base · 1150 MB cache · DDR5-4800AMD EPYC 9654 — 96 cores · 360 W · 2.4 GHz base · 384 MB cache · DDR5-4800AMD EPYC 9634 — 84 cores · 290 W · 2.25 GHz base · 384 MB cache · DDR5-4800AMD EPYC 9554 — 64 cores · 360 W · 3.1 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9534 — 64 cores · 280 W · 2.45 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9474F — 48 cores · 360 W · 3.6 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9454 — 48 cores · 290 W · 2.75 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9384X — 32 cores · 320 W · 3.1 GHz base · 768 MB cache · DDR5-4800AMD EPYC 9374F — 32 cores · 320 W · 3.85 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9354 — 32 cores · 280 W · 3.25 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9334 — 32 cores · 210 W · 2.7 GHz base · 128 MB cache · DDR5-4800AMD EPYC 9274F — 24 cores · 320 W · 4.05 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9254 — 24 cores · 200 W · 2.9 GHz base · 128 MB cache · DDR5-4800AMD EPYC 9224 — 24 cores · 200 W · 2.5 GHz base · 64 MB cache · DDR5-4800AMD EPYC 9184X — 16 cores · 320 W · 3.55 GHz base · 768 MB cache · DDR5-4800AMD EPYC 9174F — 16 cores · 320 W · 4.1 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9124 — 16 cores · 200 W · 3 GHz base · 64 MB cache · DDR5-4800EPYC 9845160 cores · 2.4 W/core — top SKU and most efficient
AMD EPYC 9005 21AMD EPYC 9004 19Bubble size = L3 cache · hover a bubble for the full SKU

SR645 V3: processors by cores and TDP

Lenovo ThinkSystem SR645 V3 processors081624324048566472808896104112120128136144152160100 W150 W200 W250 W300 W350 W400 WCores per processorAMD EPYC 9845 — 160 cores / 320 threads · 390 W · 2.1 GHz base · 320 MB cache · DDR5-6400AMD EPYC 9825 — 144 cores / 288 threads · 390 W · 2.2 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9745 — 128 cores / 256 threads · 400 W · 2.4 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9655 — 96 cores / 192 threads · 400 W · 2.6 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9655P — 96 cores / 192 threads · 400 W · 2.6 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9645 — 96 cores / 192 threads · 320 W · 2.3 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9565 — 72 cores / 144 threads · 400 W · 3.15 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9575F — 64 cores / 128 threads · 400 W · 3.3 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9555 — 64 cores / 128 threads · 360 W · 3.2 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9555P — 64 cores / 128 threads · 360 W · 3.2 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9535 — 64 cores / 128 threads · 300 W · 2.4 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9475F — 48 cores / 96 threads · 400 W · 3.65 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9455 — 48 cores / 96 threads · 300 W · 3.15 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9455P — 48 cores / 96 threads · 300 W · 3.15 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9365 — 36 cores / 72 threads · 300 W · 3.4 GHz base · 192 MB cache · DDR5-6400AMD EPYC 9375F — 32 cores / 64 threads · 320 W · 3.8 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9355 — 32 cores / 64 threads · 280 W · 3.55 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9355P — 32 cores / 64 threads · 280 W · 3.55 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9335 — 32 cores / 64 threads · 210 W · 3 GHz base · 128 MB cache · DDR5-6400AMD EPYC 9275F — 24 cores / 48 threads · 320 W · 4.1 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9255 — 24 cores / 48 threads · 200 W · 3.25 GHz base · 128 MB cache · DDR5-6400AMD EPYC 9175F — 16 cores / 32 threads · 320 W · 4.2 GHz base · 512 MB cache · DDR5-6400AMD EPYC 9135 — 16 cores / 32 threads · 200 W · 3.65 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9115 — 16 cores / 32 threads · 125 W · 2.6 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9015 — 8 cores / 16 threads · 125 W · 3.6 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9754 — 128 cores / 256 threads · 360 W · 2.25 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9734 — 112 cores / 224 threads · 340 W · 2.2 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9684X — 96 cores / 192 threads · 400 W · 2.55 GHz base · 1150 MB cache · DDR5-4800AMD EPYC 9654 — 96 cores / 192 threads · 360 W · 2.4 GHz base · 384 MB cache · DDR5-4800AMD EPYC 9634 — 84 cores / 168 threads · 290 W · 2.25 GHz base · 384 MB cache · DDR5-4800AMD EPYC 9554 — 64 cores / 128 threads · 360 W · 3.1 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9534 — 64 cores / 128 threads · 280 W · 2.45 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9474F — 48 cores / 96 threads · 360 W · 3.6 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9454 — 48 cores / 96 threads · 290 W · 2.75 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9454P — 48 cores / 96 threads · 290 W · 2.75 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9374F — 32 cores / 64 threads · 320 W · 3.85 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9384X — 32 cores / 64 threads · 320 W · 3.1 GHz base · 768 MB cache · DDR5-4800AMD EPYC 9354 — 32 cores / 64 threads · 280 W · 3.25 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9354P — 32 cores / 64 threads · 280 W · 3.25 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9334 — 32 cores / 64 threads · 210 W · 2.7 GHz base · 128 MB cache · DDR5-4800AMD EPYC 9274F — 24 cores / 48 threads · 320 W · 4.05 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9224 — 24 cores / 48 threads · 200 W · 2.5 GHz base · 64 MB cache · DDR5-4800AMD EPYC 9254 — 24 cores / 48 threads · 200 W · 2.9 GHz base · 128 MB cache · DDR5-4800AMD EPYC 9174F — 16 cores / 32 threads · 320 W · 4.1 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9184X — 16 cores / 32 threads · 320 W · 3.55 GHz base · 768 MB cache · DDR5-4800AMD EPYC 9124 — 16 cores / 32 threads · 200 W · 3 GHz base · 64 MB cache · DDR5-4800EPYC 9845160 cores · 2.4 W/core — top SKU and most efficient
AMD EPYC 9005 25AMD EPYC 9004 21Bubble size = L3 cache · hover a bubble for the full SKU

DL365 Gen11: memory with every slot filled

16 GB384 GB32 GB768 GB64 GB1.5 TB96 GB2.3 TB128 GB3 TB256 GB6 TB24 slots · 12 per processor · each tick = one DIMM

SR645 V3: memory with every slot filled

16 GB384 GB32 GB768 GB64 GB1.5 TB96 GB2.3 TB128 GB3 TB256 GB6 TB24 slots · 12 per processor · each tick = one DIMM

DL365 Gen11: drive bays

Front panel

20 × EDSFF NVMe at the front — 20 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

SR645 V3: drive bays

Front panel

16 × EDSFF NVMe at the front — 16 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

DL365 Gen11: power supplies

05001000150020002500800 W Platinum — HPE Flex Slot family; 94% efficiency; Low Halogen; AC input (Tech Specs: 800W at 100 VAC and 240 VAC; 240 VAC input for China only). Rated line voltage 100-120 / 200-240 VAC.800Platinum1000 W Titanium — HPE Flex Slot family; Standard Features: 96% efficiency; ErP Lot 9 96%-compliant part. Core Options note beside it reads 'Flex Slot Platinum Plus ... up to 94%' (contradiction, see notes). AC input.1000Titanium1600 W null — HPE Flex Slot family; -48 VDC input; 94% efficiency (no Platinum/Titanium grade printed). Requires HPE 1600W -48VDC Power Cable Lug Kit (P36877-B21) (Step 2c: lug option kit or DC PSU Power Cable Kit). Input-voltage contradiction: Standard Features says '200-240VAC power input only'; Core Options says 'support both 277VAC/380VDC power inputs'.1600DC1600 W Platinum — HPE Flex Slot family; 94% efficiency; Low Halogen; high line only (200-240 VAC).1600Platinum2200 W Titanium — Printed as 'HPE 1800W-2200W Flex Slot Titanium Hot Plug Power Supply Kit'; watts recorded as upper bound, per-voltage split not printed. HPE Flex Slot family; up to 96% efficiency; high line only (200-240 VAC); ErP Lot 9 96%-compliant. Not listed in Standard Features power supply list.2200TitaniumWatts · dashed line = output at 100–120 V low line
AC277 VAC / HVDC

SR645 V3: power supplies

0500100015002000750 W Platinum — AC input power - 80 PLUS Platinum efficiency; input 230V/115V; max quantity 2750Platinum750 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 2750Titanium750 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 2750Titanium1100 W n/a (DC input) — -48V DC input power; input -48V DC; max quantity 21100DC1100 W Platinum — AC input power - 80 PLUS Platinum efficiency; input 230V/115V; max quantity 21100Platinum1100 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 21100Titanium1800 W Platinum — AC input power - 80 PLUS Platinum efficiency; input 230V; max quantity 21800Platinum1800 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 21800TitaniumWatts · dashed line = output at 100–120 V low line
AC−48 V DC
06 — Like for like

40 processors you can order in either

Both vendor documents list these parts, so a build can be matched across the two and the comparison comes down to the chassis: 0 more are exclusive to the DL365 Gen11 and 6 to the SR645 V3.

ProcessorCoresTDP
AMD EPYC 9845160390 W
AMD EPYC 9825144390 W
AMD EPYC 9745128400 W
AMD EPYC 9754128360 W
AMD EPYC 9734112340 W
AMD EPYC 965596400 W
AMD EPYC 964596320 W
AMD EPYC 9684X96400 W
AMD EPYC 965496360 W
AMD EPYC 963484290 W
AMD EPYC 956572400 W
AMD EPYC 9575F64400 W
07 — Questions

DL365 Gen11 vs SR645 V3, answered

Is the DL365 Gen11 or the SR645 V3 the faster server?

Neither document publishes benchmark results, so this page compares what they do state. The DL365 Gen11 lists 40 processors up to 160 cores at 400 W; the SR645 V3 lists 46 up to 160 cores at 400 W. Fully populated that is 320 cores against 320.

Which holds more memory?

The DL365 Gen11 has 24 DIMM slots and a stated ceiling of 6.0 TB. The SR645 V3 has 24 and 6 TB.

Which takes more drives?

DL365 Gen11: 20 bays across 7 documented layouts. SR645 V3: 16 across 19. Counts include rear and mid-chassis positions where the vendor documents them.

Can either take GPUs?

DL365 Gen11: up to 2 accelerators, 0 double-wide cards listed. SR645 V3: up to 5, 0 double-wide listed.

Do they share any processors?

Yes — 40 processors appear in both documents, including the AMD EPYC 9845. That makes a like-for-like build possible on either server.

Where these figures come from. DL365 Gen11: HPE ProLiant DL365 Gen11 QuickSpecs (Version 45 - 08-Sep-2026) (HPE document). SR645 V3: Lenovo ThinkSystem SR645 V3 Server Product Guide (publication date is not printed in the text export; guide contains 'New as of July 2026' notes) (Lenovo document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.

Other comparisons in this class

R6625 vs DL365 Gen11Dell vs HPER6625 vs SR645 V3Dell vs LenovoR670 vs DL365 Gen11Dell vs HPER670 vs SR645 V3Dell vs LenovoR6725 vs DL365 Gen11Dell vs HPER6725 vs SR645 V3Dell vs LenovoDL360 Gen12 vs SR645 V3HPE vs LenovoDL365 Gen11 vs SR630 V4HPE vs Lenovo

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