HPE DL360 Gen12 vs Lenovo SR645 V3
A specification-by-specification comparison of the HPE ProLiant Compute DL360 Gen12 and the Lenovo ThinkSystem SR645 V3, built from HPE’s and Lenovo’s own documents. 4 headline measures favour the DL360 Gen12, 2 favour the SR645 V3, and they share no processors.
Bottom line. DL360 Gen12 leads on virtualisation, databases and in-memory work, storage density, network throughput. SR645 V3 leads on AI and acceleration. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.

The measures that decide it
Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.
Which one, and why
Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.
Choose the DL360 Gen12 if…
- Memory ceiling: 8 TB against 6 TB on the SR645 V3
- Drive bays: 20 against 16 on the SR645 V3
- Largest power supply: 2,200 W against 1,800 W on the SR645 V3
- Twenty E3.S NVMe bays in 1U — five front boxes that each take four E3.S or two U.3 SFF drives, and can be mixed.
Choose the SR645 V3 if…
- Cores, fully populated: 320 against 288 on the DL360 Gen12
- Accelerators: Up to 5 against Up to 3 on the DL360 Gen12
- Two EPYC sockets in one rack unit: a pair of 160-core 9845s gives 320 cores, and each processor drives its own 12 DDR5 channels.
Where each one pulls ahead
Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.
Side by side, differences first
Everything both documents state, grouped. The default view hides rows where the two machines are identical.
Processors
Every processor each vendor lists for the model, from its own document.
| Specification | DL360 Gen12 | SR645 V3 |
|---|---|---|
| Processors listed | 33 | 46 |
| Most cores per processor | 144 | 160 |
| Highest processor TDP | 350 W | 400 W |
| Processor families | Xeon 6 E-core · Xeon 6 P-core | AMD EPYC 9005 · AMD EPYC 9004 |
Memory
| Specification | DL360 Gen12 | SR645 V3 |
|---|---|---|
| DIMM slots | 32 | 24 |
| Slots per processor | 16 | 12 |
| Memory types | RDIMM DDR5-6400 | RDIMM DDR5-6400 (5th Gen EPYC) · RDIMM DDR5-4800 (4th Gen EPYC) · 9x4 RDIMM · 3DS RDIMM DDR5-6400 |
Storage
Bay counts are the maximum each document states, including rear and mid-chassis positions.
| Specification | DL360 Gen12 | SR645 V3 |
|---|---|---|
| Maximum bays | 20 | 16 |
| Documented layouts | 5 | 19 |
| Bay sizes | 2.5-inch · E3.S · 3.5-inch | 3.5-inch · E3.S · 2.5-inch |
| Boot devices | HPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device + 3 more | M.2 SATA/NVMe 2-Bay Enablement Kit (4Y37A09738) · M.2 SATA/x4 NVMe 2-Bay Adapter (4Y37A79663) · M.2 NVMe 2-Bay RAID Adapter (4Y37A09750) + 1 more |
| Storage controllers | 14 | 18 |
Accelerators & I/O
| Specification | DL360 Gen12 | SR645 V3 |
|---|---|---|
| Accelerators supported | Up to 3 | Up to 5 |
| OCP slots | 2 | 1 |
| PCIe network slots | 3 | 5 |
| Network cards listed | 38 | 30 |
Power & platform
| Specification | DL360 Gen12 | SR645 V3 |
|---|---|---|
| Power-supply options | 5 | 8 |
| Output range | 800–2,200 W | 750–1,800 W |
| Management | HPE iLO 7 | XClarity Controller 2 |
| Chassis depthVendors measure depth differently — see each data sheet | (8+2) SFF: 75.31 cm (29.65 in) | — |
Processors, memory, bays and power
The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.
DL360 Gen12: processors by cores and TDP
SR645 V3: processors by cores and TDP
DL360 Gen12: memory with every slot filled
SR645 V3: memory with every slot filled
DL360 Gen12: drive bays
Front panel
8 × 2.5" SAS/SATA + NVMe at the front — 8 bays in total.
SR645 V3: drive bays
Front panel
16 × EDSFF NVMe at the front — 16 bays in total.
DL360 Gen12: power supplies
SR645 V3: power supplies
DL360 Gen12 vs SR645 V3, answered
Is the DL360 Gen12 or the SR645 V3 the faster server?
Neither document publishes benchmark results, so this page compares what they do state. The DL360 Gen12 lists 33 processors up to 144 cores at 350 W; the SR645 V3 lists 46 up to 160 cores at 400 W. Fully populated that is 288 cores against 320.
Which holds more memory?
The DL360 Gen12 has 32 DIMM slots and a stated ceiling of 8.0 TB. The SR645 V3 has 24 and 6 TB.
Which takes more drives?
DL360 Gen12: 20 bays across 5 documented layouts. SR645 V3: 16 across 19. Counts include rear and mid-chassis positions where the vendor documents them.
Can either take GPUs?
DL360 Gen12: up to 3 accelerators, 0 double-wide cards listed. SR645 V3: up to 5, 0 double-wide listed.
Do they share any processors?
No. The two documents list different processors, so a like-for-like processor build is not possible across these two.
Where these figures come from. DL360 Gen12: HPE ProLiant Compute DL360 Gen12 QuickSpecs (Version 18 - 03-Aug-2026) (HPE document). SR645 V3: Lenovo ThinkSystem SR645 V3 Server Product Guide (publication date is not printed in the text export; guide contains 'New as of July 2026' notes) (Lenovo document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.
Other comparisons in this class
Talk to a UK specialist
Get expert advice or a no-obligation quote — servers, storage, networking, maintenance, finance and cloud. We reply the same working day.
