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Head-to-head · every figure from the vendor documents

HPE ML350 Gen11 vs HPE ML350 Gen12

A specification-by-specification comparison of the HPE ProLiant ML350 Gen11 and the HPE ProLiant Compute ML350 Gen12, built from HPE’s own documents. None of the headline measures favour the ML350 Gen11; 2 favour the ML350 Gen12, and they share no processors.

Bottom line. ML350 Gen12 leads on virtualisation, network throughput. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.

HPE ProLiant ML350 Gen11 tower server, front view with bezel fitted, feet extended and ProLiant ML350 Gen11 lettering on the lower bezel
HPE ProLiant
ML350 Gen11
Tower / 5U Rack2 sockets32 DIMMHPE iLO 6
Configure the ML350 Gen11 →Full data sheet
VS
HPE ProLiant Compute ML350 Gen12 tower, straight-on front view with bezel and HPE ProLiant Compute ML350 Gen12 name on the lower bezel
HPE ProLiant
ML350 Gen12
Tower / 5U Rack2 sockets32 DIMMHPE iLO 7
Configure the ML350 Gen12 →Full data sheet
01 — Scoreboard

The measures that decide it

Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.

2
Processor sockets
2
128
Cores, fully populated
Largest listed processor × its socket count
Higher172
8 TB
Memory ceiling
As each document states it
8 TB
24
Drive bays
24
Up to 8
Accelerators
Up to 8
2,200 W
Largest power supply
2,200 W
Tower / 5U Rack
Rack height
Tower / 5U Rack
100 GbE class
Fastest network option
Higher400 GbE class
02 — Verdict

Which one, and why

Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.

Choose the ML350 Gen11 if…

  • Two ways to start: the LFF chassis mixes 4LFF and 8SFF boxes up to three, while the SFF chassis stacks 8SFF boxes or swaps to one factory-fitted x4 NVMe or 12-bay E3.S cage.

Choose the ML350 Gen12 if…

  • Cores, fully populated: 172 against 128 on the ML350 Gen11
  • Fastest network option: 400 GbE class against 100 GbE class on the ML350 Gen11
  • Up to 86 P-cores per socket, 172 per server, with 88 PCIe 5.0 lanes per processor and UPI running at 24 GT/s.
03 — By workload

Where each one pulls ahead

Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.

VirtualisationML350 Gen11: 128 cores with 8 TB. ML350 Gen12: 172 cores with 8 TB.ML350 Gen12
Databases & in-memoryMemory ceiling 8 TB against 8 TB, across 32 and 32 DIMM slots.Line ball
Storage density24 bays in Tower against 24 in Tower.Line ball
AI & acceleration8 accelerators against 8 in the vendor documents.Line ball
Network throughputFastest card listed: 100 GbE class against 400 GbE class.ML350 Gen12
04 — Specifications

Side by side, differences first

Everything both documents state, grouped. The default view hides rows where the two machines are identical.

Processors

Every processor each vendor lists for the model, from its own document.

SpecificationML350 Gen11ML350 Gen12
Processors listed5718
Most cores per processor6486
Processor families4th Gen Xeon Scalable · 5th Gen Xeon ScalableXeon 6 P-core

Memory

SpecificationML350 Gen11ML350 Gen12
Largest module listed128 GB256 GB
Fastest rated speed5,600 MT/s6,400 MT/s
Memory typesRDIMM DDR5-4800 · RDIMM DDR5-5600RDIMM DDR5-6400

Storage

Bay counts are the maximum each document states, including rear and mid-chassis positions.

SpecificationML350 Gen11ML350 Gen12
Boot devicesHPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device + 1 moreHPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device + 2 more

Accelerators & I/O

SpecificationML350 Gen11ML350 Gen12
Network cards listed2926

Power & platform

SpecificationML350 Gen11ML350 Gen12
Power-supply options65
Output range500–2,200 W800–2,200 W
Input typesAC · 277 VAC / HVDCAC · −48 V DC
ManagementHPE iLO 6HPE iLO 7
05 — The data

Processors, memory, bays and power

The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.

ML350 Gen11: processors by cores and TDP

HPE ProLiant ML350 Gen11 processors0816243240485664100 W150 W200 W250 W300 W350 WCores per processorIntel Xeon Platinum 8490H — 60 cores · 350 W · 1.9 GHz base · 112.5 MB cache · DDR5-4800Intel Xeon Platinum 8480+ — 56 cores · 350 W · 2 GHz base · 105 MB cache · DDR5-4800Intel Xeon Platinum 8470 — 52 cores · 350 W · 2 GHz base · 105 MB cache · DDR5-4800Intel Xeon Platinum 8470N — 52 cores · 300 W · 1.7 GHz base · 97.5 MB cache · DDR5-4800Intel Xeon Platinum 8468 — 48 cores · 350 W · 2.1 GHz base · 105 MB cache · DDR5-4800Intel Xeon Platinum 8468V — 48 cores · 330 W · 2.4 GHz base · 97.5 MB cache · DDR5-4800Intel Xeon Platinum 8458P — 44 cores · 350 W · 2.7 GHz base · 82.5 MB cache · DDR5-4800Intel Xeon Platinum 8460Y+ — 40 cores · 300 W · 2 GHz base · 105 MB cache · DDR5-4800Intel Xeon Platinum 8452Y — 36 cores · 300 W · 2 GHz base · 67.5 MB cache · DDR5-4800Intel Xeon Gold 6430 — 32 cores · 270 W · 2.1 GHz base · 60 MB cache · DDR5-4400Intel Xeon Gold 6454S — 32 cores · 270 W · 2.2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6448H — 32 cores · 250 W · 2.4 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6414U — 32 cores · 250 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6448Y — 32 cores · 225 W · 2.1 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6438Y+ — 32 cores · 205 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6438N — 32 cores · 205 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6421N — 32 cores · 185 W · 1.8 GHz base · 60 MB cache · DDR5-4400Intel Xeon Gold 5420+ — 28 cores · 205 W · 2 GHz base · 52.5 MB cache · DDR5-4400Intel Xeon Gold 6442Y — 24 cores · 225 W · 2.6 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6418H — 24 cores · 185 W · 2.1 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 5418Y — 24 cores · 185 W · 2 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 5411N — 24 cores · 165 W · 1.9 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 5418N — 24 cores · 165 W · 1.8 GHz base · 45 MB cache · DDR5-4000Intel Xeon Silver 4416+ — 20 cores · 165 W · 2 GHz base · 37.5 MB cache · DDR5-4000Intel Xeon Gold 6416H — 18 cores · 165 W · 2.2 GHz base · 45 MB cache · DDR5-4800Intel Xeon Platinum 8444H — 16 cores · 270 W · 2.9 GHz base · 45 MB cache · DDR5-4800Intel Xeon Gold 6426Y — 16 cores · 185 W · 2.5 GHz base · 37.5 MB cache · DDR5-4800Intel Xeon Gold 5416S — 16 cores · 150 W · 2 GHz base · 30 MB cache · DDR5-4400Intel Xeon Silver 4410Y — 12 cores · 150 W · 2 GHz base · 30 MB cache · DDR5-4000Intel Xeon Gold 6434 — 8 cores · 195 W · 3.7 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Gold 5415+ — 8 cores · 150 W · 2.9 GHz base · 22.5 MB cache · DDR5-4400Intel Xeon Bronze 3408U — 8 cores · 125 W · 1.8 GHz base · 22.5 MB cache · DDR5-4000Intel Xeon Platinum 8592+ — 64 cores · 350 W · 1.9 GHz base · 320 MB cache · DDR5-5600Intel Xeon Platinum 8592V — 64 cores · 330 W · 2 GHz base · 320 MB cache · DDR5-4800Intel Xeon Platinum 8580 — 60 cores · 350 W · 2 GHz base · 300 MB cache · DDR5-5600Intel Xeon Platinum 8581V — 60 cores · 270 W · 2 GHz base · 300 MB cache · DDR5-4800Intel Xeon Platinum 8570 — 56 cores · 350 W · 2.1 GHz base · 300 MB cache · DDR5-5600Intel Xeon Platinum 8568Y+ — 48 cores · 350 W · 2.3 GHz base · 300 MB cache · DDR5-5600Intel Xeon Platinum 8558P — 48 cores · 350 W · 2.7 GHz base · 260 MB cache · DDR5-5600Intel Xeon Platinum 8558 — 48 cores · 330 W · 2.1 GHz base · 260 MB cache · DDR5-5200Intel Xeon Platinum 8558U — 48 cores · 300 W · 2 GHz base · 260 MB cache · DDR5-4800Intel Xeon Gold 6554S — 36 cores · 270 W · 2.2 GHz base · 180 MB cache · DDR5-5200Intel Xeon Gold 6530 — 32 cores · 270 W · 2.1 GHz base · 160 MB cache · DDR5-4800Intel Xeon Gold 6548Y+ — 32 cores · 250 W · 2.5 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6548N — 32 cores · 250 W · 2.8 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6538Y+ — 32 cores · 225 W · 2.2 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6538N — 32 cores · 205 W · 2.1 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 5520+ — 28 cores · 205 W · 2.2 GHz base · 52.5 MB cache · DDR5-4800Intel Xeon Gold 6542Y — 24 cores · 250 W · 2.9 GHz base · 60 MB cache · DDR5-5200Intel Xeon Silver 4516Y+ — 24 cores · 185 W · 2.2 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 6526Y — 16 cores · 195 W · 2.8 GHz base · 37.5 MB cache · DDR5-5200Intel Xeon Silver 4514Y — 16 cores · 150 W · 2 GHz base · 30 MB cache · DDR5-4400Intel Xeon Silver 4510 — 12 cores · 150 W · 2.4 GHz base · 30 MB cache · DDR5-4400Intel Xeon Gold 6534 — 8 cores · 195 W · 3.9 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Gold 5515+ — 8 cores · 165 W · 3.2 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Silver 4509Y — 8 cores · 125 W · 2.6 GHz base · 22.5 MB cache · DDR5-4400Intel Xeon Bronze 3508U — 8 cores · 125 W · 2.1 GHz base · 22.5 MB cache · DDR5-44008592+64 cores — the top SKU8581V4.5 W/core — most efficient
4th Gen Xeon Scalable 325th Gen Xeon Scalable 25Bubble size = L3 cache · hover a bubble for the full SKU

ML350 Gen12: processors by cores and TDP

HPE ProLiant Compute ML350 Gen12 processors0816243240485664728088100 W150 W200 W250 W300 W350 WCores per processorIntel Xeon 6787P — 86 cores · 350 W · 2 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6767P — 64 cores · 350 W · 2.4 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6760P — 64 cores · 330 W · 2.2 GHz base · 320 MB cache · DDR5-6400Intel Xeon 6747P — 48 cores · 330 W · 2.7 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6740P — 48 cores · 270 W · 2.1 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6736P — 36 cores · 205 W · 2 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6745P — 32 cores · 300 W · 3.1 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6737P — 32 cores · 270 W · 2.9 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6730P — 32 cores · 250 W · 2.5 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6530P — 32 cores · 225 W · 2.3 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6527P — 24 cores · 255 W · 3 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6520P — 24 cores · 210 W · 2.4 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6725P — 16 cores · 235 W · 3.7 GHz base · 192 MB cache · DDR5-6400Intel Xeon 6517P — 16 cores · 190 W · 3.2 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6515P — 16 cores · 150 W · 2.3 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6505P — 12 cores · 150 W · 2.2 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6507P — 8 cores · 150 W · 3.5 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6503P — 8 cores · 135 W · 2.8 GHz base · 48 MB cache · DDR5-64006787P86 cores · 4.1 W/core — top SKU and most efficient
Xeon 6 P-core 18Bubble size = L3 cache · hover a bubble for the full SKU

ML350 Gen11: memory with every slot filled

16 GB512 GB32 GB1 TB64 GB2 TB96 GB3 TB128 GB4 TB32 slots · 16 per processor · each tick = one DIMM

ML350 Gen12: memory with every slot filled

32 GB1 TB64 GB2 TB96 GB3 TB128 GB4 TB256 GB8 TB32 slots · 16 per processor · each tick = one DIMM

ML350 Gen11: drive bays

Front panel

12 × EDSFF NVMe at the front — 12 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

ML350 Gen12: drive bays

Front panel

12 × EDSFF NVMe at the front — 12 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

ML350 Gen11: power supplies

05001000150020002500500 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; rated 500W at 100 VAC / 240 VAC (and 240 VDC input for China only); support limited to a single 125W TDP processor configuration500Platinum800 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; rated 800W at 100 VAC / 240 VAC (and 240 VDC input for China only)800Platinum1000 W Titanium — HPE Flex Slot family; 96% power efficiency; rated 1000W at 100 VAC / 240 VAC; named 'Low Halogen' in Standard Features but not in the option list; listed as EU-ErP-compliant (96%) part number1000Titanium1600 W null — HPE Flex Slot family; -48VDC input; rated 1600W at 40 / 48 / 72 VDC; requires HPE 1600W -48VDC Power Cable Lug Kit (P36877-B21); no efficiency tier printed (see notes for a contradictory 94%/277VAC/380VDC note printed under this PSU)1600DC1600 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; 200-240 VAC high line input only; rated 1600W at 240 VAC (and 240 VDC for China only)1600Platinum2200 W Titanium — HPE Flex Slot family; '1800W-2200W' unit - 1799W at 200 VAC, 2200W at 240 VAC; 96% power efficiency; 200-240 VAC high line only; listed as EU-ErP-compliant (96%) part number2200TitaniumWatts · dashed line = output at 100–120 V low line
AC277 VAC / HVDC

ML350 Gen12: power supplies

05001000150020002500800 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; rated 800W at 100 VAC / 240 VAC (and 240 VDC for China only)800Platinum1000 W Titanium — HPE Flex Slot family; 96% power efficiency; rated 1000W at 100 VAC / 240 VAC; listed as EU-ErP-compliant part number1000Titanium1600 W null — HPE Flex Slot family; -48VDC input (40/48/72 VDC); no efficiency rating printed1600DC1600 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; 200-240VAC high line input only1600Platinum2200 W Titanium — HPE Flex Slot family; '1800W-2200W' unit - 1799W at 200 VAC, 2200W at 240 VAC; 96% power efficiency; 200-240VAC high line only; listed as EU-ErP-compliant part number2200TitaniumWatts · dashed line = output at 100–120 V low line
AC−48 V DC
07 — Questions

ML350 Gen11 vs ML350 Gen12, answered

Is the ML350 Gen11 or the ML350 Gen12 the faster server?

Neither document publishes benchmark results, so this page compares what they do state. The ML350 Gen11 lists 57 processors up to 64 cores at 350 W; the ML350 Gen12 lists 18 up to 86 cores at 350 W. Fully populated that is 128 cores against 172.

Which holds more memory?

The ML350 Gen11 has 32 DIMM slots and a stated ceiling of 8.0 TB. The ML350 Gen12 has 32 and 8.0 TB.

Which takes more drives?

ML350 Gen11: 24 bays across 4 documented layouts. ML350 Gen12: 24 across 4. Counts include rear and mid-chassis positions where the vendor documents them.

Can either take GPUs?

ML350 Gen11: up to 8 accelerators, 0 double-wide cards listed. ML350 Gen12: up to 8, 0 double-wide listed.

Do they share any processors?

No. The two documents list different processors, so a like-for-like processor build is not possible across these two.

Where these figures come from. ML350 Gen11: HPE ProLiant ML350 Gen11 QuickSpecs (Version 47 - 08-Sep-2026) (HPE document). ML350 Gen12: HPE ProLiant Compute ML350 Gen12 QuickSpecs (Version 17 - 08-Sep-2026) (HPE document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.

Other comparisons in this class

ML350 Gen11 vs ST650 V3HPE vs LenovoML350 Gen12 vs ST650 V3HPE vs Lenovo

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