HPE ML350 Gen11 vs Lenovo ST650 V3
A specification-by-specification comparison of the HPE ProLiant ML350 Gen11 and the Lenovo ThinkSystem ST650 V3, built from HPE’s and Lenovo’s own documents. 2 headline measures favour the ML350 Gen11, 3 favour the ST650 V3, and 33 processors appear in both lists.
Bottom line. ML350 Gen11 leads on virtualisation, databases and in-memory work. ST650 V3 leads on storage density. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.


The measures that decide it
Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.
Which one, and why
Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.
Choose the ML350 Gen11 if…
- Cores, fully populated: 128 against 64 on the ST650 V3
- Memory ceiling: 8 TB against 4 TB on the ST650 V3
- Two ways to start: the LFF chassis mixes 4LFF and 8SFF boxes up to three, while the SFF chassis stacks 8SFF boxes or swaps to one factory-fitted x4 NVMe or 12-bay E3.S cage.
Choose the ST650 V3 if…
- Drive bays: 32 against 24 on the ML350 Gen11
- Largest power supply: 2,600 W against 2,200 W on the ML350 Gen11
- Rack height: Tower / 4U Rack against Tower / 5U Rack on the ML350 Gen11
- Storage-rich for a tower: up to 32 × 2.5-inch or 16 × 3.5-inch hot-swap bays, and up to 24 NVMe drives with a full x4 link each, 12 of them on onboard ports.
Where each one pulls ahead
Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.
Side by side, differences first
Everything both documents state, grouped. The default view hides rows where the two machines are identical.
Processors
Every processor each vendor lists for the model, from its own document.
| Specification | ML350 Gen11 | ST650 V3 |
|---|---|---|
| Processors listed | 57 | 41 |
| Most cores per processor | 64 | 32 |
| Highest processor TDP | 350 W | 250 W |
| Processor families | 4th Gen Xeon Scalable · 5th Gen Xeon Scalable | 5th Gen Xeon Scalable · 4th Gen Xeon Scalable |
Memory
| Specification | ML350 Gen11 | ST650 V3 |
|---|---|---|
| Memory types | RDIMM DDR5-4800 · RDIMM DDR5-5600 | RDIMM DDR5-5600 (5th Gen) · RDIMM DDR5-4800 / 10x4 RDIMM (4th Gen) · 9x4 RDIMM · 3DS RDIMM |
Storage
Bay counts are the maximum each document states, including rear and mid-chassis positions.
| Specification | ML350 Gen11 | ST650 V3 |
|---|---|---|
| Maximum bays | 24 | 32 |
| Documented layouts | 4 | 6 |
| Bay sizes | 2.5-inch · 3.5-inch · E3.S | 2.5-inch · 3.5-inch |
| Boot devices | HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device + 1 more | ThinkSystem M.2 SATA/NVMe 2-Bay Enablement Kit (B5XJ) - VROC RAID · ThinkSystem M.2 RAID B540i-2i SATA/NVMe Adapter (BYFF) - integrated Broadcom RAID · ThinkSystem M.2 NVMe 2-Bay RAID Adapter (B8P9) - integrated Marvell RAID |
Accelerators & I/O
| Specification | ML350 Gen11 | ST650 V3 |
|---|---|---|
| OCP slots | 2 | 0 |
| PCIe network slots | 10 | 9 |
| Network cards listed | 29 | 11 |
Power & platform
| Specification | ML350 Gen11 | ST650 V3 |
|---|---|---|
| Output range | 500–2,200 W | 750–2,600 W |
| Input types | AC · 277 VAC / HVDC | AC |
| Management | HPE iLO 6 | XClarity Controller 2 |
| Chassis depthVendors measure depth differently — see each data sheet | Tower: 71.2 cm (28 in) deep | 734 mm |
Processors, memory, bays and power
The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.
ML350 Gen11: processors by cores and TDP
ST650 V3: processors by cores and TDP
ML350 Gen11: memory with every slot filled
ST650 V3: memory with every slot filled
ML350 Gen11: drive bays
Front panel
12 × EDSFF NVMe at the front — 12 bays in total.
ST650 V3: drive bays
Front panel
8 × 2.5" SAS/SATA at the front — 8 bays in total.
ML350 Gen11: power supplies
ST650 V3: power supplies
33 processors you can order in either
Both vendor documents list these parts, so a build can be matched across the two and the comparison comes down to the chassis: 24 more are exclusive to the ML350 Gen11 and 8 to the ST650 V3.
| Processor | Cores | TDP |
|---|---|---|
| Intel Xeon Gold 6448H | 32 | 250 W |
| Intel Xeon Gold 6438Y+ | 32 | 205 W |
| Intel Xeon Gold 6548Y+ | 32 | 250 W |
| Intel Xeon Gold 6548N | 32 | 250 W |
| Intel Xeon Gold 6538Y+ | 32 | 225 W |
| Intel Xeon Gold 6538N | 32 | 205 W |
| Intel Xeon Gold 6448Y | 32 | 225 W |
| Intel Xeon Gold 6438N | 32 | 205 W |
| Intel Xeon Gold 6414U | 32 | 250 W |
| Intel Xeon Gold 5420+ | 28 | 205 W |
| Intel Xeon Gold 5520+ | 28 | 205 W |
| Intel Xeon Gold 6418H | 24 | 185 W |
ML350 Gen11 vs ST650 V3, answered
Is the ML350 Gen11 or the ST650 V3 the faster server?
Neither document publishes benchmark results, so this page compares what they do state. The ML350 Gen11 lists 57 processors up to 64 cores at 350 W; the ST650 V3 lists 41 up to 32 cores at 250 W. Fully populated that is 128 cores against 64.
Which holds more memory?
The ML350 Gen11 has 32 DIMM slots and a stated ceiling of 8.0 TB. The ST650 V3 has 32 and 4 TB.
Which takes more drives?
ML350 Gen11: 24 bays across 4 documented layouts. ST650 V3: 32 across 6. Counts include rear and mid-chassis positions where the vendor documents them.
Can either take GPUs?
ML350 Gen11: up to 8 accelerators, 0 double-wide cards listed. ST650 V3: up to 8, 0 double-wide listed.
Do they share any processors?
Yes — 33 processors appear in both documents, including the Intel Xeon Gold 6448H. That makes a like-for-like build possible on either server.
Where these figures come from. ML350 Gen11: HPE ProLiant ML350 Gen11 QuickSpecs (Version 47 - 08-Sep-2026) (HPE document). ST650 V3: Lenovo ThinkSystem ST650 V3 Server Product Guide (no revision date printed in text (related-publication timestamps run to 2026-07-14)) (Lenovo document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.
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