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Head-to-head · every figure from the vendor documents

HPE ML350 Gen12 vs Lenovo ST650 V3

A specification-by-specification comparison of the HPE ProLiant Compute ML350 Gen12 and the Lenovo ThinkSystem ST650 V3, built from HPE’s and Lenovo’s own documents. 3 headline measures favour the ML350 Gen12, 3 favour the ST650 V3, and they share no processors.

Bottom line. ML350 Gen12 leads on virtualisation, databases and in-memory work, network throughput. ST650 V3 leads on storage density. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.

HPE ProLiant Compute ML350 Gen12 tower, straight-on front view with bezel and HPE ProLiant Compute ML350 Gen12 name on the lower bezel
HPE ProLiant
ML350 Gen12
Tower / 5U Rack2 sockets32 DIMMHPE iLO 7
Configure the ML350 Gen12 →Full data sheet
VS
Lenovo ThinkSystem ST650 V3 tower front: two 5.25-inch media bays above 32 numbered 2.5-inch hot-swap bays, operator panel and two USB ports
Lenovo ThinkSystem
ST650 V3
Tower / 4U Rack2 sockets32 DIMMXClarity Controller 2
Configure the ST650 V3 →Full data sheet
01 — Scoreboard

The measures that decide it

Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.

2
Processor sockets
2
172Higher
Cores, fully populated
Largest listed processor × its socket count
64
8 TBHigher
Memory ceiling
As each document states it
4 TB
24
Drive bays
Higher32
Up to 8
Accelerators
Up to 8
2,200 W
Largest power supply
Higher2,600 W
Tower / 5U Rack
Rack height
HigherTower / 4U Rack
400 GbE classHigher
Fastest network option
100 GbE class
02 — Verdict

Which one, and why

Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.

Choose the ML350 Gen12 if…

  • Cores, fully populated: 172 against 64 on the ST650 V3
  • Memory ceiling: 8 TB against 4 TB on the ST650 V3
  • Fastest network option: 400 GbE class against 100 GbE class on the ST650 V3
  • Up to 86 P-cores per socket, 172 per server, with 88 PCIe 5.0 lanes per processor and UPI running at 24 GT/s.

Choose the ST650 V3 if…

  • Drive bays: 32 against 24 on the ML350 Gen12
  • Largest power supply: 2,600 W against 2,200 W on the ML350 Gen12
  • Rack height: Tower / 4U Rack against Tower / 5U Rack on the ML350 Gen12
  • Storage-rich for a tower: up to 32 × 2.5-inch or 16 × 3.5-inch hot-swap bays, and up to 24 NVMe drives with a full x4 link each, 12 of them on onboard ports.
03 — By workload

Where each one pulls ahead

Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.

VirtualisationML350 Gen12: 172 cores with 8 TB. ST650 V3: 64 cores with 4 TB.ML350 Gen12
Databases & in-memoryMemory ceiling 8 TB against 4 TB, across 32 and 32 DIMM slots.ML350 Gen12
Storage density24 bays in Tower against 32 in Tower.ST650 V3
AI & acceleration8 accelerators against 8 in the vendor documents.Line ball
Network throughputFastest card listed: 400 GbE class against 100 GbE class.ML350 Gen12
04 — Specifications

Side by side, differences first

Everything both documents state, grouped. The default view hides rows where the two machines are identical.

Processors

Every processor each vendor lists for the model, from its own document.

SpecificationML350 Gen12ST650 V3
Processors listed1841
Most cores per processor8632
Highest processor TDP350 W250 W
Processor familiesXeon 6 P-core5th Gen Xeon Scalable · 4th Gen Xeon Scalable

Memory

SpecificationML350 Gen12ST650 V3
Largest module listed256 GB128 GB
Fastest rated speed6,400 MT/s5,600 MT/s
Memory typesRDIMM DDR5-6400RDIMM DDR5-5600 (5th Gen) · RDIMM DDR5-4800 / 10x4 RDIMM (4th Gen) · 9x4 RDIMM · 3DS RDIMM

Storage

Bay counts are the maximum each document states, including rear and mid-chassis positions.

SpecificationML350 Gen12ST650 V3
Maximum bays2432
Documented layouts46
Bay sizes2.5-inch · 3.5-inch · E3.S2.5-inch · 3.5-inch
Boot devicesHPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device + 2 moreThinkSystem M.2 SATA/NVMe 2-Bay Enablement Kit (B5XJ) - VROC RAID · ThinkSystem M.2 RAID B540i-2i SATA/NVMe Adapter (BYFF) - integrated Broadcom RAID · ThinkSystem M.2 NVMe 2-Bay RAID Adapter (B8P9) - integrated Marvell RAID

Accelerators & I/O

SpecificationML350 Gen12ST650 V3
OCP slots20
PCIe network slots109
Network cards listed2611

Power & platform

SpecificationML350 Gen12ST650 V3
Power-supply options56
Output range800–2,200 W750–2,600 W
Input typesAC · −48 V DCAC
ManagementHPE iLO 7XClarity Controller 2
Chassis depthVendors measure depth differently — see each data sheetTower: 71.2 cm (28 in) deep734 mm
05 — The data

Processors, memory, bays and power

The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.

ML350 Gen12: processors by cores and TDP

HPE ProLiant Compute ML350 Gen12 processors0816243240485664728088100 W150 W200 W250 W300 W350 WCores per processorIntel Xeon 6787P — 86 cores · 350 W · 2 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6767P — 64 cores · 350 W · 2.4 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6760P — 64 cores · 330 W · 2.2 GHz base · 320 MB cache · DDR5-6400Intel Xeon 6747P — 48 cores · 330 W · 2.7 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6740P — 48 cores · 270 W · 2.1 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6736P — 36 cores · 205 W · 2 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6745P — 32 cores · 300 W · 3.1 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6737P — 32 cores · 270 W · 2.9 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6730P — 32 cores · 250 W · 2.5 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6530P — 32 cores · 225 W · 2.3 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6527P — 24 cores · 255 W · 3 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6520P — 24 cores · 210 W · 2.4 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6725P — 16 cores · 235 W · 3.7 GHz base · 192 MB cache · DDR5-6400Intel Xeon 6517P — 16 cores · 190 W · 3.2 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6515P — 16 cores · 150 W · 2.3 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6505P — 12 cores · 150 W · 2.2 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6507P — 8 cores · 150 W · 3.5 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6503P — 8 cores · 135 W · 2.8 GHz base · 48 MB cache · DDR5-64006787P86 cores · 4.1 W/core — top SKU and most efficient
Xeon 6 P-core 18Bubble size = L3 cache · hover a bubble for the full SKU

ST650 V3: processors by cores and TDP

Lenovo ThinkSystem ST650 V3 processors08162432100 W150 W200 W250 WCores per processorIntel Xeon Gold 6548N — 32 cores / 64 threads · 250 W · 2.8 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6548Y+ — 32 cores / 64 threads · 250 W · 2.5 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6538Y+ — 32 cores / 64 threads · 225 W · 2.2 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6538N — 32 cores / 64 threads · 205 W · 2.1 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 5520+ — 28 cores / 56 threads · 205 W · 2.2 GHz base · 52.5 MB cache · DDR5-4800Intel Xeon Gold 5512U — 28 cores / 56 threads · 185 W · 2.1 GHz base · 52.5 MB cache · DDR5-4800Intel Xeon Gold 6542Y — 24 cores / 48 threads · 250 W · 2.9 GHz base · 60 MB cache · DDR5-5200Intel Xeon Silver 4516Y+ — 24 cores / 48 threads · 185 W · 2.2 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 6526Y — 16 cores / 32 threads · 195 W · 2.8 GHz base · 37.5 MB cache · DDR5-5200Intel Xeon Silver 4514Y — 16 cores / 32 threads · 150 W · 2 GHz base · 30 MB cache · DDR5-4400Intel Xeon Silver 4510 — 12 cores / 24 threads · 150 W · 2.4 GHz base · 30 MB cache · DDR5-4400Intel Xeon Silver 4510T — 12 cores / 24 threads · 115 W · 2 GHz base · 30 MB cache · DDR5-4400Intel Xeon Gold 6534 — 8 cores / 16 threads · 195 W · 3.9 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Gold 5515+ — 8 cores / 16 threads · 165 W · 3.2 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Bronze 3508U — 8 cores / 8 threads · 125 W · 2.1 GHz base · 22.5 MB cache · DDR5-4400Intel Xeon Silver 4509Y — 8 cores / 16 threads · 125 W · 2.6 GHz base · 22.5 MB cache · DDR5-4400Intel Xeon Gold 6414U — 32 cores / 64 threads · 250 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6448H — 32 cores / 64 threads · 250 W · 2.4 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6448Y — 32 cores / 64 threads · 225 W · 2.1 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6438M — 32 cores / 64 threads · 205 W · 2.2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6438N — 32 cores / 64 threads · 205 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6438Y+ — 32 cores / 64 threads · 205 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6428N — 32 cores / 64 threads · 185 W · 1.8 GHz base · 60 MB cache · DDR5-4000Intel Xeon Platinum 8450H — 28 cores / 56 threads · 250 W · 2 GHz base · 75 MB cache · DDR5-4800Intel Xeon Gold 5420+ — 28 cores / 56 threads · 205 W · 2 GHz base · 52.5 MB cache · DDR5-4400Intel Xeon Gold 6442Y — 24 cores / 48 threads · 225 W · 2.6 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 5412U — 24 cores / 48 threads · 185 W · 2.1 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 5418Y — 24 cores / 48 threads · 185 W · 2 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 6418H — 24 cores / 48 threads · 185 W · 2.1 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 5411N — 24 cores / 48 threads · 165 W · 1.9 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 5418N — 24 cores / 48 threads · 165 W · 1.8 GHz base · 45 MB cache · DDR5-4000Intel Xeon Silver 4416+ — 20 cores / 40 threads · 165 W · 2 GHz base · 37.5 MB cache · DDR5-4000Intel Xeon Gold 6416H — 18 cores / 36 threads · 165 W · 2.2 GHz base · 45 MB cache · DDR5-4800Intel Xeon Gold 6426Y — 16 cores / 32 threads · 185 W · 2.5 GHz base · 37.5 MB cache · DDR5-4800Intel Xeon Gold 5416S — 16 cores / 32 threads · 150 W · 2 GHz base · 30 MB cache · DDR5-4400Intel Xeon Silver 4410Y — 12 cores / 24 threads · 150 W · 2 GHz base · 30 MB cache · DDR5-4000Intel Xeon Silver 4410T — 10 cores / 20 threads · 150 W · 2.7 GHz base · 26.25 MB cache · DDR5-4000Intel Xeon Gold 6434 — 8 cores / 16 threads · 195 W · 3.7 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Gold 6434H — 8 cores / 16 threads · 195 W · 3.7 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Gold 5415+ — 8 cores / 16 threads · 150 W · 2.9 GHz base · 22.5 MB cache · DDR5-4400Intel Xeon Bronze 3408U — 8 cores / 8 threads · 125 W · 1.8 GHz base · 22.5 MB cache · DDR5-40006548N32 cores — the top SKU6428N5.8 W/core — most efficient
5th Gen Xeon Scalable 164th Gen Xeon Scalable 25Bubble size = L3 cache · hover a bubble for the full SKU

ML350 Gen12: memory with every slot filled

32 GB1 TB64 GB2 TB96 GB3 TB128 GB4 TB256 GB8 TB32 slots · 16 per processor · each tick = one DIMM

ST650 V3: memory with every slot filled

16 GB512 GB32 GB1 TB64 GB2 TB96 GB3 TB128 GB4 TB32 slots · 16 per processor · each tick = one DIMM

ML350 Gen12: drive bays

Front panel

12 × EDSFF NVMe at the front — 12 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

ST650 V3: drive bays

Front panel

8 × 2.5" SAS/SATA at the front — 8 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

ML350 Gen12: power supplies

05001000150020002500800 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; rated 800W at 100 VAC / 240 VAC (and 240 VDC for China only)800Platinum1000 W Titanium — HPE Flex Slot family; 96% power efficiency; rated 1000W at 100 VAC / 240 VAC; listed as EU-ErP-compliant part number1000Titanium1600 W null — HPE Flex Slot family; -48VDC input (40/48/72 VDC); no efficiency rating printed1600DC1600 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; 200-240VAC high line input only1600Platinum2200 W Titanium — HPE Flex Slot family; '1800W-2200W' unit - 1799W at 200 VAC, 2200W at 240 VAC; 96% power efficiency; 200-240VAC high line only; listed as EU-ErP-compliant part number2200TitaniumWatts · dashed line = output at 100–120 V low line
AC−48 V DC

ST650 V3: power supplies

050010001500200025003000750 W Platinum — 230V/115V (BNFG v3); max 2750Platinum1100 W Platinum — 230V/115V (BNFH v3); max 21100Platinum1100 W Titanium — 230V only (BLKH); C13/C14; max 2; 240V DC PRC1100Titanium1800 W Platinum — 230V only (BMUF v2); max 21800Platinum1800 W Titanium — 230V only (BPK9); max 21800Titanium2600 W Titanium — 230V only, C19 connector (BKTJ v4); max 22600TitaniumWatts · dashed line = output at 100–120 V low line
AC
07 — Questions

ML350 Gen12 vs ST650 V3, answered

Is the ML350 Gen12 or the ST650 V3 the faster server?

Neither document publishes benchmark results, so this page compares what they do state. The ML350 Gen12 lists 18 processors up to 86 cores at 350 W; the ST650 V3 lists 41 up to 32 cores at 250 W. Fully populated that is 172 cores against 64.

Which holds more memory?

The ML350 Gen12 has 32 DIMM slots and a stated ceiling of 8.0 TB. The ST650 V3 has 32 and 4 TB.

Which takes more drives?

ML350 Gen12: 24 bays across 4 documented layouts. ST650 V3: 32 across 6. Counts include rear and mid-chassis positions where the vendor documents them.

Can either take GPUs?

ML350 Gen12: up to 8 accelerators, 0 double-wide cards listed. ST650 V3: up to 8, 0 double-wide listed.

Do they share any processors?

No. The two documents list different processors, so a like-for-like processor build is not possible across these two.

Where these figures come from. ML350 Gen12: HPE ProLiant Compute ML350 Gen12 QuickSpecs (Version 17 - 08-Sep-2026) (HPE document). ST650 V3: Lenovo ThinkSystem ST650 V3 Server Product Guide (no revision date printed in text (related-publication timestamps run to 2026-07-14)) (Lenovo document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.

Other comparisons in this class

T560 vs ST650 V3Dell vs LenovoML350 Gen11 vs ST650 V3HPE vs LenovoML350 Gen11 vs ML350 Gen12Generation upgrade

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