Technical data sheet · ProLiant Compute Gen12 · 4U tower (5U racked), dual-socket

HPE ProLiant Compute ML350 Gen12Specifications, configurations & comparisons

The ProLiant Compute ML350 Gen12 is HPE’s two-socket Xeon 6 tower: 6500P and 6700P processors of up to 86 cores, 32 DDR5-6400 slots, and a single chassis whose three front boxes take SFF, LFF, NVMe or E3.S cages in most combinations. This data sheet follows the QuickSpecs through those cage rules, the ambient-temperature choice on every build, GPU limits and the rack conversion.

Tower / 5U Rack1 or 2 socketsXeon 6 P-coreHPE iLO 7

86cores per CPU172 per server · Xeon 6 P-core

8.0TBDDR5 maximum32 DIMM slots

24drive bays4 drive-cage kits

8GPUs5 accelerators listed

2,200Wlargest PSU5 supply options

18processor SKUs1 family

Configure an ML350 Gen12 →Get a UK quote Refurbished alternatives ↓

Every figure checked against the HPE ProLiant Compute ML350 Gen12 QuickSpecs (Version 17 - 08-Sep-2026)

Image: Hewlett Packard Enterprise

Form factor: Tower / 5U Rack · 2 sockets
Processors: Xeon 6 P-core
Memory: 32 × DDR5 RDIMM · up to 8.0 TB
Drive bays: Up to 24 · 4 drive-cage kits
Expansion: 10 × PCIe · 2 × OCP 3.0
GPUs: Up to 8 · 5 listed
Boot: NS204i · 5 boot options
Management: HPE iLO 7

01 — Overview

The ML350 Gen12 at a glance

Our read of HPE’s documentation: where the ML350 Gen12 is strong, and the limits worth knowing before you spec one.

Strengths

Up to 86 P-cores per socket, 172 per server, with 88 PCIe 5.0 lanes per processor and UPI running at 24 GT/s.
Memory runs at 6400 MT/s with one DIMM per channel or 5200 MT/s with two, reaching 8.0 TB on 256 GB 3DS RDIMMs.
Drive cages are chosen one at a time: tri-mode SFF and dual-mode LFF cages mix freely, and either can sit beside a 12-bay E3.S or an x4 NVMe cage, three cages in all.
Twenty-four NVMe SSDs at PCIe 5.0 x2 each, from three x4 NVMe cages on x2 cable kits.
The Gen5 x16 RTX PRO 4500 Blackwell joins the L40, L40S, L4 and RTX A1000 on the GPU list.

Watch-outs

HPE ties every build to a 30 °C, 27 °C or 25 °C ambient-temperature tracking SKU, and the E3.S cage forces the 25 °C option.
An internal LTO drive limits the server to two drive cages, and any NS204i-u boot device must then use the rear enablement kit.
Here the MR932i-p runs NVMe SSDs only, in the x4 NVMe or E3.S cages — no hard drives, no SATA SSDs.
HPE’s performance test builds declare 4.9 B at idle and 5.0 B operating, against 4.0 B and 4.1–4.2 B for the entry builds.
From 225 W a processor needs the Performance heat sink; from 300 W — and with 256 GB DIMMs, E3.S, 200 Gb-plus networking or any GPU — both extra fan kits as well.

Processors18 SKUs

Cores / CPU8–86

DIMM slots32

Drive-cage kits4

Max bays24

GPUsup to 8

PSU options5 · to 2,200 W

02 — Processors

18 supported processors, mapped

Eighteen Xeon 6 P-core processors are listed for the ML350 Gen12 — 6500P and 6700P parts from the 8-core 6503P and 6507P to the 86-core 6787P, drawing 135 W to 350 W. No E-core or 6900-series parts are offered for this tower. The landscape places every SKU by cores and TDP, and the explorer filters them.

Processor landscape — cores × TDP

18 SKUs · 1 family

Xeon 6 P-core 18Bubble size = L3 cache · hover a bubble for the full SKU

Processor explorer

filter · sort · compare

Sort

Processor	Cores / threads	Base	L3 cache	TDP	W / core	Memory
Intel Xeon 6787P	86	2 GHz	336 MB	350 W	4.1	DDR5-6400
Intel Xeon 6767P	64	2.4 GHz	336 MB	350 W	5.5	DDR5-6400
Intel Xeon 6760P	64	2.2 GHz	320 MB	330 W	5.2	DDR5-6400
Intel Xeon 6747P	48	2.7 GHz	288 MB	330 W	6.9	DDR5-6400
Intel Xeon 6740P	48	2.1 GHz	288 MB	270 W	5.6	DDR5-6400
Intel Xeon 6736P	36	2 GHz	144 MB	205 W	5.7	DDR5-6400
Intel Xeon 6745P	32	3.1 GHz	336 MB	300 W	9.4	DDR5-6400
Intel Xeon 6737P	32	2.9 GHz	144 MB	270 W	8.4	DDR5-6400
Intel Xeon 6730P	32	2.5 GHz	288 MB	250 W	7.8	DDR5-6400
Intel Xeon 6530P	32	2.3 GHz	144 MB	225 W	7.0	DDR5-6400
Intel Xeon 6527P	24	3 GHz	144 MB	255 W	10.6	DDR5-6400
Intel Xeon 6520P	24	2.4 GHz	144 MB	210 W	8.8	DDR5-6400
Intel Xeon 6725P	16	3.7 GHz	192 MB	235 W	14.7	DDR5-6400
Intel Xeon 6517P	16	3.2 GHz	72 MB	190 W	11.9	DDR5-6400
Intel Xeon 6515P	16	2.3 GHz	72 MB	150 W	9.4	DDR5-6400
Intel Xeon 6505P	12	2.2 GHz	48 MB	150 W	12.5	DDR5-6400
Intel Xeon 6507P	8	3.5 GHz	48 MB	150 W	18.8	DDR5-6400
Intel Xeon 6503P	8	2.8 GHz	48 MB	135 W	16.9	DDR5-6400

Two processors must be the same model.
The Performance heat sink (P72359-B21) starts at 225 W; at 300 W the Redundant Fan Kit and Second CPU Fan Kit are added.
The highest base clock is the 6725P’s 3.7 GHz (16 cores, 235 W), added to the QuickSpecs in a later revision.
HPE’s table gives the 32-core 6745P 336 MB of L3 cache and the 48-core 6747P 288 MB; figures shown as printed.
Option kits hold the processor only; heat sinks and fans are ordered separately.

03 — Memory

32 DIMM slots, 16 per processor

Eight DDR5 channels per processor, each with two RDIMM slots: 32 slots when both sockets are filled, 16 with one. HPE’s rating is 6400 MT/s for a single DIMM per channel, dropping to 5200 MT/s once both slots are used — the speed of the full 8.0 TB build.

Capacity with every slot filled

by DIMM size

Operating speed

per HPE memory tables

Processor	1 DIMM / channel	2 DIMMs / channel
Intel Xeon 6 (6500P / 6700P)	6400 MT/s	5200 MT/s

Kits are 32, 64, 96 and 128 GB RDIMMs plus a 256 GB 3DS RDIMM, all rated DDR5-6400.
Each socket takes 1, 2, 4, 8, 12 or 16 DIMMs.
The 64, 96, 128 and 256 GB sizes can’t be combined with any other capacity, and x4 and x8 DIMMs never mix.
A population note limits 16 GB DIMMs to one per channel, though no 16 GB kit is offered.
Advanced ECC is the listed protection, and the option list contains no MRDIMMs.

04 — Storage

4 drive-cage kits, up to 24 bays

The Gen12 comes as one configure-to-order chassis with no drive cage fitted. You add up to three from four types — 8SFF x1 tri-mode, 4LFF, 8SFF x4 NVMe and 12EDSFF — plus a slim DVD bay; HPE’s default Smart Chassis starts with one tri-mode 8SFF box and an MR408i-o. The layouts are the single-type maximums; the kit chart lists each cage.

Headline layouts

front panel view

Front panel

Three 8SFF x1 tri-mode boxes: 24 SAS, SATA or x1 NVMe drives through tri-mode controllers, 368.64 TB raw with 15.36 TB SSDs.

SAS/SATANVMeSAS/SATA + NVMe

Controllers & boot

HPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device — Boot. RAID1-protected M.2 NVMe boot device; requires Second CPU Fan Kit (P47902-B21) plus front (P74252-B21) or rear (P72360-B21) enablement kit
HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device — Boot. RAID1-protected M.2 NVMe boot device
HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device — Boot. RAID1-protected self-encrypting M.2 NVMe boot device
Intel Virtual RAID on CPU (VROC) RAID 1 FIO Software for HPE — Software RAID. Intel VROC NVMe for HPE ProLiant Compute Gen12; RAID 1; NVMe SSDs only, no PCIe card support; UEFI mode only
Intel Virtual RAID on CPU (VROC) RAID 1 E-RTU for HPE — Software RAID. RAID 1; field-deployment (BTO) equivalent of S3Q19A
Intel Virtual RAID on CPU (VROC) Premium FIO Software for HPE — Software RAID. RAID 0/1/5/10; NVMe SSDs only; UEFI mode only
Intel Virtual RAID on CPU (VROC) Premium E-RTU for HPE — Software RAID. RAID 0/1/5/10; field-deployment (BTO) equivalent of R7J57A
HPE MR216i-o Gen11 x16 Lanes without Cache OCP SPDM Storage Controller — RAID. OCP (OROC, OCP A slot only); does not occupy a PCIe expansion slot; up to 16 SAS/SATA/NVMe drives with RAID 0/1/10
HPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device (P78279-B21) — boot
HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device (P81160-B21) — boot
HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device (P81162-B21) — boot
HPE ProLiant Compute ML350 Gen12 NS204i-u Front Enablement Kit (P74252-B21) — boot

All 16 controllers and 5 boot options

HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Plug-in Storage Controller — RAID. PCIe plug-in; up to 16 SAS/SATA/NVMe drives with RAID 0/1/10
HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller — RAID, 4GB cache. OCP (OROC); does not occupy a PCIe expansion slot; up to 8 SAS/SATA/NVMe drives; requires HPE 96W Smart Storage Battery (P01367-B21) or Smart Hybrid Capacitor (P02381-B21 / P65042-B21). Default controller in the ML350 Gen12 default Smart Chassis.
HPE MR408i-p Gen11 x8 Lanes 4GB Cache PCI SPDM Plug-in Storage Controller — RAID, 4GB cache. PCIe plug-in; up to 8 SAS/SATA/NVMe drives; requires battery or hybrid capacitor
HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller — RAID, 8GB cache. OCP (OROC); does not occupy a PCIe expansion slot; up to 16 SAS/SATA/NVMe drives; requires battery or hybrid capacitor
HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Plug-in Storage Controller — RAID, 8GB cache. PCIe plug-in; up to 16 SAS/SATA/NVMe drives; requires battery or hybrid capacitor
HPE MR932i-p x32 Lanes PCIe Gen5 SPDM Plug-in Storage Controller — RAID. PCIe plug-in; up to 32 lanes; NVMe and SAS SSD only (no HDD, no SATA SSD); on ML350 Gen12 supports only NVMe SSDs in the 8SFF NVMe x4 (P72316-B21) or 12EDSFF (P72320-B21) cages
HPE Smart Array E208e-p SR Gen10 (8 External Lanes/No Cache) 12G SAS PCIe Plug-in Controller — RAID. PCIe; external SAS RAID controller
HPE Smart Array E208e-p SR Gen12 x8 Lanes without Cache SAS 12G PCIe Plug-in Controller — RAID. PCIe; external; 8 SAS lanes across 2 x4 Mini-SAS HD ports; not shown in Smart Chassis steps
HPE ProLiant Compute ML350 Gen12 NS204i-u Rear Enablement Kit (P72360-B21) — boot

On x4 cable kits the NVMe cages stop at two, 16 drives at full x4 bandwidth; x2 kits allow three. x2 and x4 kits, and direct-attach and controller kits, can’t be mixed, and the x4 NVMe cage can’t be combined with the E3.S cage.
An MR932i-p serves up to two x4 cages on x2 kits, while on x4 kits every cage set needs its own MR932i-p.
OCP-form RAID controllers fit OCP A only and need no enablement kit; the MR408i and MR416i must be ordered with a Smart Storage battery or hybrid capacitor.
The boot option is an NS204i-u v2 in 480 GB, 960 GB or 960 GB self-encrypting form, fitted with a front or rear enablement kit plus the Second CPU Fan Kit.
One internal LTO-8 or LTO-9 drive fits the Box 1 and media-bay position, with the tertiary riser (P79317-B21), an LTO cable kit and a free port on an MR216i or MR408i controller.
External SAS runs from an E208e-p, offered in both Gen10 and Gen12 versions.
The storage table prints 183.6 TB for twelve 15.36 TB E3.S drives, whose product is 184.32 TB.

Every documented drive-cage kit

4 with drive bays

2.5-inch3.5-inchEDSFF (E1.S / E3.S)

05 — Accelerators & I/O

GPUs, PCIe and networking

Five NVIDIA GPUs are supported, one model per server, each requiring the Redundant and Second CPU fan kits. HPE rates every card against drive-cage count: the L4 and RTX A1000 are rated at 30 °C with two or three cages but, as printed, only with processors of 190 W or less when one cage is fitted; the RTX PRO 4500 holds 30 °C with one cage; and the L40 slips from 27 °C with one cage to 23 °C with three unless HPE’s two-GPU limited setup is used. Up to 8 × RTX A1000, 4 × L40, L4 or RTX PRO 4500, or 2 × L40S (slot 2 and/or 6 on an x16 riser).

NVIDIA L40 48GB PCIe Accelerator for HPE

48GB · 4

NVIDIA L40S 48GB PCIe Accelerator for HPE

48GB · 2

NVIDIA RTX PRO 4500 Blackwell Server Edition 32GB PCIe Accelerator for HPE

32GB · 4

NVIDIA RTX A1000 8GB PCIe Accelerator for HPE

8GB · 8

NVIDIA L4 24GB PCIe Accelerator for HPE

24GB · 4

I/O topology

88 lanes per CPU

Each Xeon 6 processor here brings 88 PCIe 5.0 lanes and eight memory channels. Processor 1 runs the primary riser; the secondary and tertiary risers depend on processor 2, giving up to ten slots with both. OCP B is the default networking slot, and OCP A is where OCP-form RAID controllers go.

Network adapters HPE lists

26 options

Adapter	Ports	Form
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE	4 × 1GbE	OCP 3.0
Intel E610-IT4 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE	4 × 1GbE	OCP 3.0
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter for HPE	2 × 10GbE	OCP 3.0
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T OCP3 Adapter for HPE	2 × 10GbE	OCP 3.0
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Mellanox MCX631432AS-ADAI Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 OCP3 Adapter for HPE	4 × 10/25GbE	OCP 3.0
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 OCP3 Adapter for HPE	2 × 100GbE	OCP 3.0
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE	4 × 1GbE	PCIe
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE	2 × 10GbE	PCIe
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE	2 × 10GbE	PCIe
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE	4 × 10/25GbE	PCIe
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Mellanox MCX631102AS-ADAT Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Intel E810-XXVDA4 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE	4 × 10/25GbE	PCIe
NVIDIA Ethernet 10/25Gb 2-port SFP28 NVMe-oF Crypto Adapter for HPE	2 × 10/25GbE	PCIe
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 Adapter for HPE	2 × 100GbE	PCIe
NVIDIA Ethernet 100Gb 2-port NVMe-oF Offload Adapter for HPE	2 × 100GbE	PCIe
HPE InfiniBand NDR/Ethernet 400Gb 1-port OSFP PCIe5 x16 MCX75310AAS-NEAT Adapter	1 × InfiniBand NDR / 400GbE	PCIe
HPE InfiniBand NDR200/Ethernet 200GbE 2-port QSFP112 PCIe5 x16 MCX755106AC-HEAT Adapter	2 × InfiniBand NDR200 / 200GbE	PCIe
HPE SN1610Q 32Gb 1-port Fibre Channel Host Bus Adapter	1 × 32Gb Fibre Channel	PCIe
HPE SN1610Q 32Gb 2-port Fibre Channel Host Bus Adapter	2 × 32Gb Fibre Channel	PCIe
HPE SN1700Q 64Gb 1-port Fibre Channel Host Bus Adapter	1 × 64Gb Fibre Channel	PCIe
HPE SN1700Q 64Gb 2-port Fibre Channel Host Bus Adapter	2 × 64Gb Fibre Channel	PCIe

The secondary riser kits are interchangeable with the primary kit; the 2x16 primary version is a factory-only option.
The tertiary riser uses two of processor 2’s MCIO connectors, and without processor 2 its slots do nothing.
A card in OCP B needs the OCP B Enablement Kit; an x16 NIC in OCP A may need the OCP A kit. HPE’s OCP cable kits run x16 from processor 1 to OCP A, and x8 from either processor or x16 from processor 2 to OCP B.
InfiniBand adapters and the x16-only Ethernet cards need a 2x16 riser.
Ethernet or InfiniBand at 200 Gb or faster also calls for the Redundant Fan Kit.
There is no embedded NIC; configure-to-order builds default to a Broadcom BCM5719 four-port 1 Gb OCP3 adapter.

06 — Power & cooling

5 power supplies, 800–2,200 W

Up to two Flex Slot hot-plug supplies of one model, a pair giving 1+1 redundancy. The five on the list span 800 W to 2200 W: Platinum at 800 W and 1600 W, Titanium at 1000 W and 1800–2200 W, and one −48 V DC supply of 1600 W.

AC−48 V DC

Only high-line 200–240 V AC feeds suit the two largest AC units (1600 W Platinum, 1800–2200 W Titanium).
Configure-to-order servers ship without power cords; any cords ordered must match the number of supplies.
HPE’s entry acoustic builds (one 6507P, one 800 W supply, default fans) declare 4.0 B at idle; the performance LFF and SFF builds reach 4.9 B idle and 5.0 B operating.
At 240 V AC the 800 W supply is rated for up to 2,949 BTU/hr and the 1800–2200 W supply for 7,962 BTU/hr.
Three system fans are standard and up to eight fit; up to two External GPU Fan Kits cover the back of the risers.

07 — Management, security & OS

Run it, secure it, choose the OS

Management

HPE iLO 7 on the iLO 7 ASIC
Gen12 firmware signed with CNSA 2.0 quantum-resistant algorithms
Three-year HPE Compute Ops Management subscription added by default
iLO Advanced and HPE OneView optional
Intelligent Provisioning due post-launch; features with iLO or RESTful Interface Tool alternatives were removed
Dedicated 1 Gb rear iLO port · front iLO service port

Security

iLO-managed and UEFI-managed encryption with self-encrypting drives
One-button secure erase to NIST SP 800-88
FIPS 140-3, NIST SP 800-53 and SP 800-171 compliance
Embedded TPM support
System maintenance switch, USB security, bezel lock and chassis intrusion switch
HPE Trusted Supply Chain option

Operating systems

For OS and hypervisor support HPE points to its Servers Support & Certification Matrices rather than listing versions in the QuickSpecs
UEFI Class 3 · Secure Boot and Secure Start
Redfish Secure Boot key management · old VMware Secure Boot key retirement

08 — Compare

How the ML350 Gen12 compares with its family

The ML350 Gen12 is the Xeon 6 model in HPE’s ProLiant tower line. The ML350 Gen11 before it runs 4th and 5th Gen Xeon Scalable; the ML110 Gen11 and ML30 Gen11 are single-socket towers. For a rack, the DL380 Gen12 is the two-socket Xeon 6 2U and the DL340 Gen12 the single-socket one. Bars are drawn from each spec file.

This modelSiblings and successorEach value from that model’s own verified spec file · bars scale per column

ML350 Gen11 data sheet ML110 Gen11 data sheet ML30 Gen11 data sheet DL380 Gen12 data sheet DL340 Gen12 data sheet Dell PowerEdge T560 data sheet Lenovo ThinkSystem ST650 V3 data sheet

09 — Use cases

Four builds that suit the ML350 Gen12

Four ML350 Gen12 builds made from options the configurator accepts on this tower; each link opens the configurator pre-filled. It sets one of each chosen cage and two supplies, so additional cages, riser, fan, enablement and cable kits and the ambient-temperature SKU are set on the quote.

Virtualisation

64-core Xeon 6 virtualisation tower

Two 32-core 6730P processors — the part HPE uses in its performance SFF acoustic build — and 1 TB of DDR5-6400 at one DIMM per channel host a mid-sized VMware estate. The storage copies HPE’s default Smart Chassis, a tri-mode 8SFF box behind an MR408i-o in OCP A, filled with 7.68 TB SAS SSDs.

2 × Xeon 6730P — 32 cores @ 2.5 GHz, 250 W each
16 × 64 GB DDR5-6400 RDIMM — 1 TB at 6400 MT/s
8 × 7.68 TB SAS SSD in one tri-mode 8SFF box
MR408i-o 4 GB cache controller in OCP A
Broadcom BCM57414 2 × 10/25GbE OCP3 in OCP B
2 × 1000 W Flex Slot Titanium
VMware vSphere 8 Essentials Plus

The 250 W processors need the Performance heat sink (P72359-B21), the second processor adds the Second CPU Fan Kit, and OCP B needs its enablement kit; the ambient-temperature tracking SKU for your room is chosen on the quote.

Open this build in the configurator →

All-flash

24-drive NVMe analytics and file server

Three x4 NVMe cages on x2 cable kits take 24 NVMe SSDs; with 7.68 TB drives that is 184.32 TB raw. Direct-attached, the third cage set needs processor 2, which two 36-core 6736P processors at 205 W supply, and Intel VROC Premium adds RAID 0, 1, 5 and 10 without a controller card.

2 × Xeon 6736P — 36 cores @ 2 GHz, 205 W each
8 × 7.68 TB NVMe U.3 in one 8SFF cage — 61.44 TB raw as linked
16 × 32 GB DDR5-6400 RDIMM — 512 GB
Intel VROC Premium (RAID 0/1/5/10)
NS204i-u v2 boot device
Intel E810-CQDA2 2 × 100GbE OCP3
2 × 1600 W Flex Slot Platinum (200–240 V AC)
Red Hat Enterprise Linux 9 (3-year)

The link opens with one generic 8SFF cage; all three 8SFF x4 NVMe cages (P72316-B21) and their x2 cable kits are specified on the quote. HPE doesn’t allow x2 and x4 kits, or direct-attach and controller kits, in one server.

Open this build in the configurator →

Backup & tape

Disk-plus-tape backup tower

With an internal LTO drive HPE allows two drive cages, so this build pairs a 4LFF box of 26 TB SAS drives (104 TB raw) as a disk landing zone with a tri-mode 8SFF box of SATA SSDs. One 16-core 6515P at 150 W stays below the Performance heat-sink threshold, and a 16-drive MR216i-o has ports for the disks and the tape.

1 × Xeon 6515P — 16 cores @ 2.3 GHz, 150 W
4 × 26 TB 3.5-inch SAS HDD in a 4LFF box — 104 TB raw
4 × 1.92 TB SATA SSD in a tri-mode 8SFF box
8 × 32 GB DDR5-6400 RDIMM — 256 GB
MR216i-o controller in OCP A
Broadcom BCM57416 2 × 10GbE BASE-T OCP3
2 × 800 W Flex Slot Platinum
Windows Server 2025 Standard

Add the LTO drive, tertiary riser (P79317-B21), LTO cable kit and Second CPU Fan Kit on the quote. With tape fitted, a boot device must use the rear NS204i-u enablement kit, and the front kit is ruled out.

Open this build in the configurator →

GPU compute

Four RTX PRO 4500 GPU tower

Four 32 GB RTX PRO 4500 Blackwell cards run at PCIe Gen5 x16, two per 2x16 riser, for 128 GB of GPU memory, and 512 GB of DDR5 respects HPE’s two-to-one memory guideline. Two 16-core 6517P processors at 190 W also meet the 190 W processor limit that HPE attaches to several ratings in its GPU inlet table.

2 × Xeon 6517P — 16 cores @ 3.2 GHz, 190 W each
4 × NVIDIA RTX PRO 4500 Blackwell 32 GB
16 × 32 GB DDR5-6400 RDIMM — 512 GB
4 × 3.84 TB NVMe U.3 in the tri-mode 8SFF box
MR408i-o controller in OCP A
Intel E810-XXVDA2 2 × 10/25GbE OCP3
2 × 1800–2200 W Flex Slot Titanium (200–240 V AC)
Red Hat Enterprise Linux 9

Every card needs the ML350 12(8+4)-pin/16-pin power cable kit and both system fan kits; HPE recommends the External GPU Fan Kit, which covers the cards’ DisplayPorts. With one drive cage the RTX PRO 4500 is supported at 30 °C inlet.

Open this build in the configurator →

10 — Refurbished alternatives

When a refurbished ProLiant makes more sense

Nothing in our refurbished HPE range is Xeon 6 or DDR5; it covers Gen10 and Gen10 Plus. The ML350 Gen10 is the tower choice, and two Gen10 Plus rack servers suit buyers who can rack the machine and want more memory slots.

Gen10 · re-certified

HPE ProLiant ML350 Gen10

Tower / 4U rack · 2 × Xeon Scalable
24 DIMM slots · up to 3 TB DDR4
Up to 24 × SFF or 12 × LFF
iLO 5

A tower for sites without a server room where two-socket Xeon Scalable, DDR4 and iLO 5 are enough.

Configure a refurbished ML350 Gen10 →

Gen10 Plus · re-certified

HPE ProLiant DL380 Gen10 Plus

2U rack · 2 × Ice Lake Xeon
32 DIMM slots · up to 8 TB DDR4-3200
PCIe 4.0 · OCP 3.0
iLO 5

Intel virtualisation or database hosts that will sit in a rack and need the same 32 memory slots as the ML350 Gen12.

Configure a refurbished DL380 Gen10 Plus →

Gen10 Plus · re-certified

HPE ProLiant DL385 Gen10 Plus

2U rack · 2 × AMD EPYC 7002/7003
Up to 128 cores · 32 DIMM slots
Up to 8 TB DDR4-3200 · PCIe 4.0
iLO 5

Core-heavy consolidation on AMD EPYC, up to 128 cores, where staying with Intel isn’t a requirement.

Configure a refurbished DL385 Gen10 Plus →

Refurbished HPE ProLiant servers Refurbished ProLiant configurator New vs refurbished cost calculator

11 — Full specifications

HPE ProLiant Compute ML350 Gen12 specifications

Chassis & cooling

Form factor	4U tower · 5U racked with the Tower-to-Rack kit (P47394-B21)
CTO chassis	One chassis (P72297-B21), no default drive cage
Dimensions (H × W × D)	Tower 46.2 × 17.4 × 71.2 cm · rack system 17.4 × 44.5 × 64.8 cm
Weight	SFF 23.96–42.28 kg · LFF 24.41–45.13 kg
Fans	3 standard · up to 8 · up to 2 external GPU fan kits
Ambient tracking SKU	30 °C (default), 27 °C or 25 °C

Processor

Sockets	One or two (same model)
Family	Intel Xeon 6 6500P / 6700P (P-core)
Cores per processor	8 to 86
TDP	135 W to 350 W
Listed SKUs	18
Interconnect	UPI 24 GT/s · 88 PCIe 5.0 lanes per processor

Memory

Slots	32 DDR5 RDIMM (16 with one processor) · 8 channels × 2 DIMMs
Kits	32, 64, 96, 128 GB RDIMM · 256 GB 3DS RDIMM — DDR5-6400
Speed	6400 MT/s (1 DPC) · 5200 MT/s (2 DPC)
Maximum	8.0 TB (32 × 256 GB at 5200 MT/s)
Protection	Advanced ECC

Storage

Cages	Up to 3: 8SFF x1 tri-mode, 4LFF, 8SFF x4 NVMe (2 on x4 kits, 3 on x2 kits), 12EDSFF (1)
Maximum	24 SFF · 24 NVMe (x2) · 12 LFF · 12 E3.S
Maximum raw	312 TB LFF · 368.64 TB SFF
Controllers	VROC · MR216i, MR408i, MR416i (-o and -p) · MR932i-p (NVMe only) · E208e-p Gen10 / Gen12
Boot	NS204i-u v2 480 GB, 960 GB or 960 GB SED · front or rear kit
Tape & optical	One internal LTO-8 or LTO-9 · slim DVD bay

Expansion & networking

PCIe slots	Up to 10 × PCIe 5.0: primary 4 × x8 or 2 × x16 · secondary 4 × x8 or 2 × x16 · tertiary 2 × x8
OCP	OCP A (x8, OROC controllers) · OCP B (default NIC, WOL)
LOM	None · CTO default BCM5719 4 × 1 Gb OCP3

Accelerators

Models (max)	L40 (4) · L40S (2) · RTX PRO 4500 (4) · L4 (4) · RTX A1000 (8)
Rules	Both fan kits · no mixing · two x16 cards per 2x16 riser

Power

Supplies	Up to 2 × Flex Slot hot-plug, 1+1, no mixing
AC	800 W Platinum · 1000 W Titanium · 1600 W Platinum (200–240 V) · 1800–2200 W Titanium (200–240 V)
DC	1600 W −48 V DC

Ports & video

Front	USB 3.2 Gen 1 · DisplayPort · iLO service port
Rear	2 × USB 3.2 Gen 1 · VGA · 1 Gb iLO · optional serial
Internal	2 × USB 3.2 Gen 1
Video	1920 × 1200 at 60 Hz · 16 MB

Environment & warranty

Operating temperature	10–35 °C · extended 5–45 °C for approved configurations
Acoustics (LWA,m)	4.0–4.9 B idle · 4.1–5.0 B operating
Warranty	3 years parts, labour and on-site, next business day

12 — FAQ

ML350 Gen12 questions, answered from the documentation

What is the maximum memory of the HPE ProLiant ML350 Gen12?

8.0 TB, from 32 × 256 GB 3DS RDIMMs at two per channel, which HPE rates at 5200 MT/s. Staying at one DIMM per channel for the full 6400 MT/s leaves 16 slots — 2 TB with 128 GB kits or 4 TB with 256 GB. A one-processor server has 16 slots in total.

Which processors does the ML350 Gen12 support?

Up to two matching Intel Xeon 6 P-core processors from the 6500P and 6700P series. HPE lists 18, with 8 to 86 cores and TDPs between 135 W and 350 W; a pair of 86-core 6787P gives the server 172 cores.

How many drives does the ML350 Gen12 hold?

Up to 24 SFF drives (tri-mode, or NVMe on x2 cable kits), 12 LFF or 12 E3.S, in at most three cages. SFF and LFF boxes can be combined, and the E3.S cage may share the front with them. An internal tape drive lowers the limit to two cages.

Can the ML350 Gen12 be converted to a rack server?

Yes — the optional Tower-to-Rack kit (P47394-B21) lets it occupy 5U in a standard rack. HPE doesn’t fit the kit in the factory; it arrives as a standalone option.

Which GPUs fit the ML350 Gen12?

One of five NVIDIA models per server: eight RTX A1000, four L40, L4 or RTX PRO 4500, or two L40S in slot 2 and/or slot 6 on an x16 riser. All need the Redundant and Second CPU fan kits, and the x16 cards need 2x16 risers holding two cards each.

What is the ambient-temperature tracking SKU on the ML350 Gen12?

HPE asks for the highest inlet temperature the server will face — 30 °C, 27 °C or 25 °C — and configures cooling to suit. Its default Smart Chassis assumes 30 °C, and choosing the 12EDSFF cage requires the 25 °C SKU.

How loud is the ML350 Gen12?

For its entry LFF and SFF builds HPE declares 4.0 B (28–29 dBA) at idle; the performance builds reach 4.9 B at idle and 5.0 B (37–38 dBA) operating. Operating mode is measured at 50 % of processor TDP in a 23 ± 2 °C room.

Which power supplies does the ML350 Gen12 use?

It holds up to two hot-plug Flex Slot supplies, always a matched pair. HPE lists five: an 1800–2200 W and a 1000 W Titanium, a 1600 W and an 800 W Platinum, and a 1600 W model for −48 V DC. The two biggest AC units are high-line only, and configure-to-order servers ship with no power cords.

How does the ML350 Gen12 differ from the ML350 Gen11?

Comparing the two QuickSpecs: the Gen11 uses 4th and 5th Gen Xeon Scalable up to 64 cores with DDR5-4800 or 5600 and iLO 6, sold as separate LFF and SFF chassis. The Gen12 takes Xeon 6 P-core parts up to 86 cores, runs DDR5-6400 (its 8.0 TB maximum is rated at 5200 MT/s, where Gen11’s is 4400) and iLO 7, and drops the 500 W supply and A16 GPU while adding the RTX PRO 4500. The tower still measures 46.2 × 17.4 × 71.2 cm.

Is the HPE ProLiant Compute ML350 Gen12 end of life?

No end-of-sale or end-of-support date appears in HPE’s QuickSpecs (version 17, 8 September 2026), which lists the server for configure-to-order; its obsolete entries are individual drives, memory and adapters. Warranty is three years parts, labour and on-site, and our end-of-life checker will carry HPE’s dates when announced.

Sources & verification

Where these figures come from

HPE ProLiant Compute ML350 Gen12 QuickSpecs (Version 17 - 08-Sep-2026) — Overview, processor table and option-kit notes, memory and population rules, riser and OCP tables, storage controllers and maximum storage, Smart Chassis and ambient-temperature SKUs, drive cages and cable kits, LTO and boot options, accelerators, cooling kits, power supplies, interfaces, security, technical specifications and acoustics.
HPE ProLiant ML350 Gen11 QuickSpecs (Version 47 - 08-Sep-2026) — Gen11 facts in the generation FAQ.

Specifications are extracted from HPE’s published documents and independently re-checked line by line. Configurations are quote-based; availability and exact options are confirmed at quotation. Last reviewed 2026-09-11.

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The ML350 Gen12 at a glance

Strengths

Watch-outs

18 supported processors, mapped

Processor landscape — cores × TDP

Processor explorer

32 DIMM slots, 16 per processor

Capacity with every slot filled

Operating speed

4 drive-cage kits, up to 24 bays

Headline layouts

Controllers & boot

Every documented drive-cage kit

GPUs, PCIe and networking

NVIDIA L40 48GB PCIe Accelerator for HPE

NVIDIA L40S 48GB PCIe Accelerator for HPE

NVIDIA RTX PRO 4500 Blackwell Server Edition 32GB PCIe Accelerator for HPE

NVIDIA RTX A1000 8GB PCIe Accelerator for HPE

NVIDIA L4 24GB PCIe Accelerator for HPE

I/O topology

Network adapters HPE lists

5 power supplies, 800–2,200 W

Run it, secure it, choose the OS

Management

Security

Operating systems

How the ML350 Gen12 compares with its family

Four builds that suit the ML350 Gen12

64-core Xeon 6 virtualisation tower

24-drive NVMe analytics and file server

Disk-plus-tape backup tower

Four RTX PRO 4500 GPU tower

When a refurbished ProLiant makes more sense

HPE ProLiant ML350 Gen10

HPE ProLiant DL380 Gen10 Plus

HPE ProLiant DL385 Gen10 Plus

HPE ProLiant Compute ML350 Gen12 specifications

Chassis & cooling

Processor

Memory

Storage

Expansion & networking

Accelerators

Power

Ports & video

Environment & warranty

ML350 Gen12 questions, answered from the documentation

Where these figures come from

Buy & configure

Guides & family

Plan the deployment

Support & lifecycle

Get a quote for the HPE ProLiant Compute ML350 Gen12

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