Technical data sheet · ProLiant Gen11 tower · 4.5U tower or 5.5U rack, single socket

HPE ProLiant ML110 Gen11Specifications, configurations & comparisons

The ProLiant ML110 Gen11 puts one 4th or 5th Gen Xeon Scalable processor, sixteen DDR5 RDIMM slots and PCIe 5.0 into a 4.5U tower that converts to a 5.5U rack server. HPE aims it at mid-tier work in small offices, branch sites and growing SMBs that need only one socket. This page covers its processors, memory rules, two-cage storage, GPU risers, power and HPE’s acoustic advice.

Tower / 5.5U Rack1 socket4th Gen Xeon Scalable5th Gen Xeon ScalableHPE iLO 6

32cores maximumXeon Gold 6421N · one socket

1.5TBDDR5 RDIMM maximum16 × 96 GB · 5th Gen Xeon

16SFF hot-plug baystwo 8SFF cages · or 8 LFF

4PCIe 5.0 x16 slots2 standard + 2 on GPU risers

2GPUsNVIDIA L4 or RTX 4000 Ada

22dBAidle bystander noiseall four HPE test builds

Configure an ML110 Gen11 →Get a UK quote Refurbished alternatives ↓

Every figure checked against the HPE ProLiant ML110 Gen11 QuickSpecs (Version 36 - 13-Jul-2026)

Image: Hewlett Packard Enterprise

Form factor: Tower / 5.5U Rack · 1 socket
Processors: 4th Gen Xeon · 5th Gen Xeon
Memory: 16 × DDR5 RDIMM · up to 1.5 TB
Drive bays: Up to 16 · 7 drive-cage kits
Expansion: 4 × PCIe · 1 × OCP 3.0
GPUs: Up to 2 · 2 listed
Boot: M.2 and NS204i · 8 boot options
Management: HPE iLO 6

01 — Overview

The ML110 Gen11 at a glance

Our read of HPE’s documentation: where the ML110 Gen11 is strong, and the limits worth knowing before you spec one.

Strengths

Eighteen single-socket Xeon Scalable options across 4th and 5th Gen, from 8 to 32 cores and 125 W to 185 W, including one-socket-optimised U parts.
Sixteen RDIMM slots on eight channels — 1.5 TB with 96 GB DDR5-5600 modules on 5th Gen processors, 1 TB with 64 GB DDR5-4800 on 4th Gen.
Two PCIe 5.0 x16 slots from the factory, two more through GPU riser kits, and an OCP 3.0 x16 slot that takes either a network adapter or an OCP RAID controller.
Up to two drive cages — sixteen SFF or eight LFF hot-plug bays, or four LFF plus eight SFF on the LFF chassis — and two onboard M.2 slots on top.
Three years of parts, labour and on-site cover as standard, and a tower-to-rack kit for a later move into a cabinet.

Watch-outs

An NVIDIA L4 caps the processor at 150 W TDP, needs the GPU riser, L4 support and redundant fan kits, and limits inlet air to 25°C.
No NVMe drive bays: NVMe is M.2 only — two onboard slots or the NS204i-u, which occupies the embedded controller’s port.
Noise climbs with performance parts: 24 dBA operating for HPE’s Entry builds but 37 dBA for its Performance SFF build.
The Bronze 3508U is limited to PCIe Gen4, and the 3508U, Silver 4510 and 4509Y lose VROC NVMe RAID and the 96 GB DIMM.
The 1600 W supply runs on 200–240 VAC only, and any 96 GB DIMM limits inlet temperature to 25°C.

Processors18 SKUs

Cores / CPU8–32

DIMM slots16

Drive-cage kits7

Max bays16

GPUsup to 2

PSU options4 · to 1,600 W

02 — Processors

18 supported processors, mapped

HPE lists eleven 4th Gen and seven 5th Gen Xeon Scalable processors — Bronze, Silver and Gold — for the ML110’s single socket. The chart plots cores against TDP: the 32-core Gold 6421N heads the 4th Gen list and the 28-core Gold 5512U the 5th Gen list, both at 185 W.

Processor landscape — cores × TDP

18 SKUs · 2 families

4th Gen Xeon Scalable 115th Gen Xeon Scalable 7Bubble size = L3 cache · hover a bubble for the full SKU

Processor explorer

filter · sort · compare

Sort

Processor	Cores / threads	Base	L3 cache	TDP	W / core	Memory
Intel Xeon-Gold 6421N	32	1.8 GHz	60 MB	185 W	5.8	DDR5-4400
Intel Xeon-Gold 5512U	28	2.1 GHz	52.5 MB	185 W	6.6	DDR5-4800
Intel Xeon-Gold 5418Y	24	2 GHz	45 MB	185 W	7.7	DDR5-4400
Intel Xeon-Gold 5412U	24	2.1 GHz	45 MB	185 W	7.7	DDR5-4400
Intel Xeon-Gold 5411N	24	1.9 GHz	45 MB	165 W	6.9	DDR5-4400
Intel Xeon-Gold 5418N	24	1.8 GHz	45 MB	165 W	6.9	DDR5-4000
Intel Xeon-Silver 4516Y+	24	2.2 GHz	45 MB	185 W	7.7	DDR5-4400
Intel Xeon-Silver 4416+	20	2 GHz	37.5 MB	165 W	8.3	DDR5-4000
Intel Xeon-Gold 6426Y	16	2.5 GHz	37.5 MB	185 W	11.6	DDR5-4800
Intel Xeon-Gold 5416S	16	2 GHz	30 MB	150 W	9.4	DDR5-4000
Intel Xeon-Silver 4514Y	16	2 GHz	30 MB	150 W	9.4	DDR5-4400
Intel Xeon-Silver 4410Y	12	2 GHz	30 MB	150 W	12.5	DDR5-4000
Intel Xeon-Silver 4510	12	2.4 GHz	30 MB	150 W	12.5	DDR5-4400
Intel Xeon-Gold 5415+	8	2.9 GHz	22.5 MB	150 W	18.8	DDR5-4400
Intel Xeon-Bronze 3408U	8	1.8 GHz	22.5 MB	125 W	15.6	DDR5-4000
Intel Xeon-Gold 5515+	8	3.2 GHz	22.5 MB	165 W	20.6	DDR5-4800
Intel Xeon-Silver 4509Y	8	2.6 GHz	22.5 MB	125 W	15.6	DDR5-4400
Intel Xeon-Bronze 3508U	8	2.1 GHz	22.5 MB	125 W	15.6	DDR5-4400

Six parts are asterisked and show UPI as N/A: the Gold 6421N, 5412U, 5411N and 5512U and the Bronze 3408U and 3508U. HPE’s suffix decoder describes U parts as supported in one-socket configurations only.
Rated memory speed varies by part: 4800 MT/s for the Gold 6426Y, 5512U and 5515+; 4000 MT/s for the Gold 5418N, Silver 4416+ and 4410Y and Bronze 3408U; 4400 MT/s for the others.
The Gold 5416S appears at 4400 MT/s in the processor table but at 4000 MT/s in its option-kit note.
Three processors in the Standard Features table — the Gold 5412U and 5418N and the Bronze 3408U — have no option kit in the Step 2a lists.
The Bronze 3508U supports PCIe up to Gen4 only. The chipset is Intel’s C741; HPE gives no thread counts or turbo clocks.

03 — Memory

16 DDR5 DIMM slots

Sixteen RDIMM slots on eight channels, two per channel. HPE ties DIMM speed to processor generation: DDR5-4800 kits of 16, 32 and 64 GB for 4th Gen Xeon, and DDR5-5600 kits of 16, 32, 64 and 96 GB for 5th Gen. The ceilings are 1.0 TB and 1.5 TB, both quoted at 4400 MT/s with two DIMMs per channel.

Capacity with every slot filled

by DIMM size

Rated memory speed

from the processor table

Processor family	Up to
4th Gen Xeon Scalable	4800 MT/s
5th Gen Xeon Scalable	4800 MT/s

Populate 1, 2, 4, 6, 8, 12 or 16 DIMMs.
The 96 GB DDR5-5600 DIMM is not supported with the Silver 4510 and 4509Y or the Bronze 3508U, and it restricts inlet air to 25°C with fans running faster and louder.
Ranks can be mixed on a channel only as a 2R DIMM in the white slot with a 1R in the black, and only with all sixteen slots filled; x4 and x8 DIMMs cannot share the socket, nor RDIMMs mix with LRDIMMs.
Protection is Advanced ECC, which corrects single- and multi-bit errors confined to one DRAM chip.
The population guidelines mention 128 GB and 256 GB 3DS RDIMMs, but no such kit appears in the ML110 memory options.

04 — Storage

7 drive-cage kits, up to 16 bays

Three CTO chassis set the first cage — 4 LFF non-hot-plug SATA, 4 LFF hot-plug SAS/SATA or 8 SFF hot-plug SAS/SATA — and a second cage kit doubles it. The LFF hot-plug chassis can also take an 8SFF cage for a mixed front, while the non-hot-plug chassis cannot mix cage types. Every front bay is SAS or SATA; NVMe is confined to M.2.

Headline layouts

front panel view

Front panel

Two 8SFF hot-plug cages (SFF chassis P51518-B21 plus kit P53483-B21). HPE’s largest listed build is 245.76 TB with sixteen 15.36 TB SAS SSDs; with 2.4 TB SAS hard drives it is 38.4 TB.

SAS/SATANVMeSAS/SATA + NVMe

Controllers & boot

Embedded 8 SATA ports controller with Intel VROC Hybrid RAID — Software RAID. Embedded/onboard. Supports SATA RAID with up to 4+4 LFF or 8 SFF drives and 2x M.2 SATA drives. SATA drives only; additional controller required for SAS.
Intel VROC SATA for HPE ProLiant Gen11 — Software RAID. RAID 0/1/5/10. UEFI mode only; off by default and must be enabled.
Intel Virtual RAID on CPU RAID 1 FIO Software for HPE (VROC NVMe) — Software RAID. Supports RAID 1 on up to 2x onboard M.2 NVMe drives. Factory-integrated (FIO).
Intel Virtual RAID on CPU RAID 1 E-RTU for HPE (VROC NVMe) — Software RAID. Supports RAID 1 on up to 2x onboard M.2 NVMe drives. Field deployment (BTO) equivalent of S3Q19A.
HPE Smart Array E208e-p SR Gen10 (8 External Lanes/No Cache) 12G SAS PCIe Plug-in Controller — RAID. PCIe. Essential RAID controller; supports up to 8 SAS/SATA drives (external).
HPE MR216i-o Gen11 x16 Lanes without Cache OCP SPDM Storage Controller — RAID. OCP. Tri-mode; does not occupy a PCIe expansion slot; up to 16 SAS/SATA/NVMe drives with RAID 0/1/10.
HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Plug-in Storage Controller — RAID. PCIe. Tri-mode; up to 16 SAS/SATA/NVMe drives with RAID 0/1/10.
HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller — RAID, 4GB cache. OCP. Tri-mode; does not occupy a PCIe expansion slot; up to 8 SAS/SATA/NVMe drives. Requires P01367-B21 battery cable kit OR P02381-B21 hybrid capacitor cable kit.
HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device (P48183-B21) - 2 x M.2 NVMe, RAID1 protected, max 480 GB usable per Maximum Storage table (2 x 480 GB) — boot
HPE ProLiant ML110 Gen11 NS204i-u Enablement Kit (P61742-B21) - required when NS204i-u is selected — boot
Onboard M.2 slots: 2 x M.2 SATA or 2 x M.2 NVMe (SATA/NVMe M.2 SSD onboard slot max 960 GB / 3.84 TB) — boot
HPE 480GB SATA 6G Read Intensive M.2 Multi Vendor SSD (P47818-B21) — boot

All 12 controllers and 8 boot options

HPE MR408i-p Gen11 x8 Lanes 4GB Cache PCI SPDM Plug-in Storage Controller — RAID, 4GB cache. PCIe. Tri-mode; up to 8 SAS/SATA/NVMe drives. Requires P01367-B21 OR P02381-B21.
HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller — RAID, 8GB cache. OCP. Tri-mode; does not occupy a PCIe expansion slot; up to 16 SAS/SATA/NVMe drives. Requires P01367-B21 OR P02381-B21.
HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Plug-in Storage Controller — RAID, 8GB cache. PCIe. Tri-mode; up to 16 SAS/SATA/NVMe drives. Requires P01367-B21 OR P02381-B21.
HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device — Boot. 2x M.2 NVMe RAID1 boot device. Requires NS204i-u Enablement Kit P61742-B21 and Redundant Fan Kit P49984-B21; not supported on the NHP CTO server; occupies the embedded storage controller port (no LFF/SFF bay support when selected).
HPE 480GB NVMe Gen4 Mainstream Performance Read Intensive M.2 2280 PE9010 SSD (P80318-B21) — boot
HPE 960GB NVMe Gen4 Mainstream Performance Read Intensive M.2 2280 PE9010 SSD (P80321-B21) — boot
HPE 1.92TB NVMe Gen4 Mainstream Performance Read Intensive M.2 2280 PE9010 SSD (P80324-B21) — boot
HPE 960GB NVMe Gen4 Mainstream Performance Read Intensive M.2 2280 Self-encrypting PE9010 SSD (P80327-B21) — boot

The embedded Intel VROC SATA controller reaches 4+4 LFF or 8 SFF drives plus two M.2 SATA SSDs, in RAID 0, 1, 5 or 10. It is off by default, runs in UEFI mode only, and handles SATA only — SAS drives need an added controller.
The tri-mode MR controllers come in OCP form (MR216i-o, MR408i-o, MR416i-o), which leave the PCIe slots free, and as PCIe cards (MR216i-p, MR408i-p, MR416i-p). The cached models need a battery or hybrid-capacitor energy pack, and MR and SR internal controllers cannot be mixed.
Two onboard M.2 slots take two SATA or two NVMe M.2 SSDs, never a mix; NVMe RAID 1 across them needs Intel VROC RAID 1 (S3Q19A or S3Q39AAE).
The NS204i-u (two 480 GB M.2 NVMe in RAID 1) needs its enablement kit and the redundant fan kit, is unsupported on the NHP chassis, and takes the embedded controller’s port, leaving embedded SATA unavailable to the bays.
The media area holds one optical drive and one half-height internal LTO drive; the LTO drive needs the P62356-B21 cable kit and a port on an MR216i or MR408i-o controller.

Every documented drive-cage kit

6 with drive bays

2.5-inch3.5-inchEDSFF (E1.S / E3.S)

05 — Accelerators & I/O

GPUs, PCIe and networking

Two NVIDIA cards, up to two of either but never mixed: the L4 24 GB, which goes only on the GPU riser kits, and the RTX 4000 Ada, which can sit in slots 1 to 3 with its 8-pin/16-pin cable kit. Every accelerator needs the redundant fan kit, and HPE recommends system memory at twice the accelerator memory. Version 34’s change log records adding an NVIDIA RTX A1000 8GB, yet no A1000 appears in Version 36’s accelerator options. Up to 2 × NVIDIA L4 (riser slots, CPU ≤ 150 W, 25°C inlet) or 2 × RTX 4000 Ada (slots 1–3); double-width cards only in slot 2.

NVIDIA L4 24GB PCIe Accelerator for HPE

24GB · 2

NVIDIA RTX 4000 Ada Graphics Accelerator for HPE

I/O topology

1 socket

The four slot positions all run from the single processor at PCIe 5.0 x16. Slots 1 and 4 are fitted from the factory; the GPU riser kit adds slot 2 and the second riser kit slot 3. A separate OCP 3.0 slot, also Gen5 x16, is shared between network adapters and OCP-type RAID controllers.

Network adapters HPE lists

19 options

Adapter	Ports	Form
Embedded 2-Port 1GbE BCM5720 networking ports	2 × 1GbE	embedded
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE	4 × 1GbE	PCIe
Intel I350-T4 Ethernet 1Gb 4-port BASE-T Adapter for HPE	4 × 1GbE	PCIe
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE	2 × 10GbE	PCIe
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE	2 × 10GbE	PCIe
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Mellanox MCX631102AS-ADAT Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Intel E810-XXVDA4 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE	4 × 10/25GbE	PCIe
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 Adapter for HPE	2 × 100GbE	PCIe
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE	4 × 1GbE	OCP 3.0
Intel I350-T4 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE	4 × 1GbE	OCP 3.0
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter for HPE	2 × 10GbE	OCP 3.0
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T OCP3 Adapter for HPE	2 × 10GbE	OCP 3.0
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Mellanox MCX631432AS-ADAI Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 OCP3 Adapter for HPE	4 × 10/25GbE	OCP 3.0
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 OCP3 Adapter for HPE	2 × 100GbE	OCP 3.0

A double-width card fits only in slot 2 and makes slot 3 unavailable; the second riser kit requires the first.
With the GPU riser installed, HPE recommends an additional PCIe adapter in slot 2 to keep thermals in check.
Network adapters run to 100GbE with the Intel E810-CQDA2 in PCIe or OCP form, alongside 1GbE, 10GbE and 10/25GbE cards from Broadcom, Intel and Mellanox.
Front: DisplayPort, one USB 3.2 Gen 1 and the iLO service port. Rear: VGA, two USB 3.2 Gen 1, two 1GbE, the dedicated iLO port and an optional serial port.

06 — Power & cooling

4 power supplies, 500–1,600 W

Up to two HPE Flex Slot hot-plug supplies: Platinum at 500 W, 800 W or 1600 W, or Titanium at 1000 W. Two identical units give 1+1 redundancy; mixing two different supplies is not supported.

The 1600 W unit needs 200–240 VAC; the 500 W, 800 W and 1000 W units are rated at both 100 VAC and 240 VAC.
Maximum heat output at 100 VAC is 1902 BTU/hr (500 W), 3067 BTU/hr (800 W) and 3741 BTU/hr (1000 W); the 1600 W unit reaches 5918 BTU/hr at 200 VAC.
HPE quotes 94% efficiency for the Platinum units and 96% for the 1000 W Titanium.
The 1600 W supply is sold as Platinum but labelled Titanium in the power-output specifications.
Two non-hot-plug fans are standard. The Redundant Fan Kit (P49984-B21) is mandatory for 10K or 15K SAS SFF drives, SAS4 SSDs, the NS204i-u, any GPU, riding through a fan failure and A3/A4 operation.

07 — Management, security & OS

Run it, secure it, choose the OS

Management

HPE iLO 6 (iLO 6 ASIC · 64 MB flash, 8 Gbit DDR4 with ECC)
iLO Standard with Intelligent Provisioning · iLO Advanced (licensed)
Dedicated rear 1GbE iLO port · front iLO service port
HPE Compute Ops Management (subscription included on CTO servers)
HPE OneView Standard · OneView Advanced (licensed)
iLO RESTful API (Redfish) · IPMI 2.0 · SNMP v3

Security

Immutable Silicon Root of Trust
UEFI Secure Boot and Secure Start
TPM 2.0 (embedded)
FIPS 140-3 and Common Criteria (iLO 6 certification in progress)
Digitally signed updates, Secure Recovery and firmware rollback
Secure erase of NAND
Front bezel key-lock (tower and rack), padlock and Kensington slots
Optional chassis intrusion detection

Operating systems

No OS list in the QuickSpecs — HPE refers to its Servers Support & Certification Matrices
Intel VROC SATA: Windows and Linux · VROC NVMe: Windows, Linux and VMware
Microsoft logo certifications and Microsoft Secure Code support listed

08 — Compare

How the ML110 Gen11 compares with its family

The ML110 Gen11 sits between the ML30 Gen11 and MicroServer Gen11 on one side and the ML350 on the other. The ML30 and MicroServer use Xeon 6300, Xeon E-2400 or Pentium processors with four UDIMM slots and a 128 GB ceiling; the ML110 moves to Xeon Scalable, RDIMMs and OCP 3.0. The ML350 Gen11 is the tower above, with two sockets and 32 DIMM slots, and the DL320 Gen11 is a 1U single-socket Xeon Scalable rack server.

This modelSiblings and successorEach value from that model’s own verified spec file · bars scale per column

ML30 Gen11 data sheet MicroServer Gen11 data sheet ML350 Gen11 data sheet ML350 Gen12 data sheet DL320 Gen11 data sheet Dell PowerEdge T560 data sheet Lenovo ThinkSystem ST650 V3 data sheet Dell PowerEdge T360 data sheet Lenovo ThinkSystem ST250 V3 data sheet

09 — Use cases

Four builds that suit the ML110 Gen11

Four ML110 Gen11 configurations: a 512 GB hypervisor, a two-L4 inference node, a quiet LFF file server and a branch database. All of them validate in our HPE configurator, where each can be opened as a starting point.

Virtualisation

Single-socket hypervisor with 512 GB

The 28-core Gold 5512U is a one-socket-optimised 5th Gen part, and eight 64 GB DDR5-5600 RDIMMs put one module on each of its eight channels. An OCP MR416i-o with 8 GB cache runs the eight SAS SSDs without using a PCIe slot, leaving slots for a 25GbE card and later growth.

1 × Xeon-Gold 5512U — 28 cores @ 2.1 GHz, 185 W
8 × 64 GB DDR5-5600 RDIMM — 512 GB, one per channel
8 × 3.84 TB 2.5-inch SAS SSD — 30.72 TB raw
HPE MR416i-o OCP controller, 8 GB cache
Intel E810-XXVDA2 2 × 10/25GbE SFP28 PCIe
2 × 1000 W Flex Slot Titanium, hot-plug (1+1)
Windows Server 2025 Datacenter
HPE Tech Care Essential

The MR416i-o occupies the OCP slot and needs an energy pack plus the SFF OROC cable kit (P53485-B21), so networking goes on a PCIe card. If the SSDs are 24G SAS4 models the Redundant Fan Kit becomes mandatory, and HPE lists SAS4 drives among options to avoid in noise-sensitive rooms.

Open this build in the configurator →

AI inference

Two NVIDIA L4 cards for on-site inference

HPE allows two L4s on the riser kits provided the processor stays at or below 150 W, so this build uses the 16-core, 150 W Silver 4514Y. 256 GB of RDIMM is well over twice the 48 GB of GPU memory, and SATA SSDs on embedded VROC keep the OCP slot free for 25GbE.

1 × Xeon-Silver 4514Y — 16 cores @ 2 GHz, 150 W
2 × NVIDIA L4 24 GB on the GPU riser kits
8 × 32 GB DDR5-5600 RDIMM — 256 GB
4 × 7.68 TB 2.5-inch SATA SSD — 30.72 TB raw
Embedded Intel VROC SATA RAID
Broadcom BCM57414 2 × 10/25GbE SFP28 OCP 3.0
2 × 1000 W Flex Slot Titanium, hot-plug (1+1)
Red Hat Enterprise Linux 9 (3-year subscription)
HPE Tech Care Essential

Two L4s need the GPU riser kit, the second GPU riser kit, the L4 support kit and the Redundant Fan Kit; the support kit’s DIMM blanks go in the eight empty slots. The embedded controller reaches the SFF cage through the SFF OROC cable kit (P53485-B21). Inlet air is limited to 25°C, and HPE lists accelerators among the options that raise fan noise.

Open this build in the configurator →

Office file server

Quiet LFF file server following HPE’s acoustic advice

For noise-sensitive rooms HPE recommends LFF cages and SATA drives and avoiding fast SAS drives, the NS204i-u, 96 GB DIMMs and accelerators. Its Entry LFF test build — a 125 W Bronze processor, a SATA LFF drive and a 500 W supply — measured 22 dBA idle and 24 dBA operating. This build follows that pattern with the 125 W Silver 4509Y.

1 × Xeon-Silver 4509Y — 8 cores @ 2.6 GHz, 125 W
4 × 16 GB DDR5-5600 RDIMM — 64 GB
4 × 24 TB 3.5-inch SATA HDD, hot-plug — 96 TB raw
Embedded Intel VROC SATA RAID
Embedded 2 × 1GbE (Broadcom BCM5720)
2 × 500 W Flex Slot Platinum, hot-plug (1+1)
Windows Server 2025 Standard
HPE Tech Care Basic

HPE’s acoustic figures come from single-drive test builds, so a full cage may be louder. The 4509Y supports neither the 96 GB DIMM nor VROC NVMe RAID; a second 4LFF cage kit takes the server to eight bays.

Open this build in the configurator →

Branch database

SQL server with mirrored NS204i-u boot

The 16-core Gold 6426Y is the only 4th Gen processor on HPE’s list rated for DDR5-4800, which suits eight 32 GB DDR5-4800 RDIMMs. An MR408i-p runs eight SAS SSDs while the NS204i-u keeps the operating system on a mirrored M.2 pair, and a 10GbE OCP adapter leaves the PCIe slots for the controller and growth.

1 × Xeon-Gold 6426Y — 16 cores @ 2.5 GHz, 185 W
8 × 32 GB DDR5-4800 RDIMM — 256 GB
8 × 1.92 TB 2.5-inch SAS SSD — 15.36 TB raw
HPE MR408i-p tri-mode controller, 4 GB cache
HPE NS204i-u boot device (2 × 480 GB M.2 NVMe, RAID 1)
Broadcom BCM57412 2 × 10GbE SFP+ OCP 3.0
2 × 800 W Flex Slot Platinum, hot-plug (1+1)
Windows Server 2025 Standard
HPE Tech Care Critical

The NS204i-u needs its enablement kit and the Redundant Fan Kit and raises fan noise; HPE suggests the onboard M.2 slots as a quieter boot option. Pair the MR408i-p with a battery or hybrid-capacitor energy pack, and with cable kit P55859-B21 for the SFF cage.

Open this build in the configurator →

10 — Refurbished alternatives

When a refurbished ProLiant makes more sense

Our refurbished HPE configurator covers Gen10 and Gen10 Plus. One tower and two rack servers there overlap with what an ML110 Gen11 buyer usually needs.

Gen10 · re-certified

HPE ProLiant ML350 Gen10

Tower · 2 × Xeon Scalable
24 DIMM slots · up to 3 TB DDR4
Up to 24 × SFF or 12 × LFF
iLO 5

When you want to stay with a tower and value a second socket and more bays over DDR5.

Configure a refurbished ML350 Gen10 →

Gen10 Plus · re-certified

HPE ProLiant DL325 Gen10 Plus

1U rack · 1 × EPYC 7002/7003
Up to 64 cores
16 DIMM slots · up to 4 TB DDR4
10 × SFF / NVMe bays

A single-socket host with more cores and NVMe bays, if the server can go in a rack.

Configure a refurbished DL325 Gen10 Plus →

Gen10 · re-certified

HPE ProLiant DL380 Gen10

2U rack · 2 × Xeon Scalable
24 DIMM slots · up to 3 TB DDR4
Up to 24 × SFF or 12 × LFF
GPU-capable · iLO 5

Rack-mounted file, backup or GPU duty where a two-socket 2U with up to 24 SFF bays suits better than a single-socket tower.

Configure a refurbished DL380 Gen10 →

Refurbished HPE ProLiant servers Refurbished ProLiant configurator New vs refurbished cost calculator

11 — Full specifications

HPE ProLiant ML110 Gen11 specifications

Chassis & cooling

Form factor	4.5U tower · 5.5U in a rack with conversion kit P47394-B21
Tower (H × W × D)	46.2 × 19.5 × 58.7 cm (18.19 × 7.68 × 23.1 in)
Rack, system only (H × W × D)	19.5 (4.5U) × 44.5 × 58.7 cm
Weight	20.1 kg (SFF minimum) to 33.2 kg (LFF maximum)
CTO chassis	LFF NHP (P51516-B21) · LFF (P51517-B21) · SFF (P51518-B21)
Fans	2 standard, non-hot-plug · Redundant Fan Kit P49984-B21

Processor

Sockets	One
Families	4th Gen Xeon Scalable (11) · 5th Gen Xeon Scalable (7)
Cores	8–32
TDP	125–185 W (150 W maximum with NVIDIA L4)
Chipset	Intel C741

Memory

Slots	16 × DDR5 RDIMM · 8 channels, 2 DIMMs per channel
DIMM kits	16/32/64 GB DDR5-4800 (4th Gen) · 16/32/64/96 GB DDR5-5600 (5th Gen)
Maximum	1.5 TB (16 × 96 GB, 5th Gen) · 1.0 TB (16 × 64 GB, 4th Gen)
Protection	Advanced ECC

Storage

Front bays	8 or 16 × 2.5" SAS/SATA · 4 or 8 × 3.5" SAS/SATA or NHP SATA · 4 LFF + 8 SFF mixed on the LFF chassis
Largest listed	245.76 TB (16 × 15.36 TB SAS SSD) · 208 TB (8 × 26 TB LFF, per the Maximum Storage table)
Controllers	Intel VROC SATA (embedded) · MR216i, MR408i, MR416i in -o (OCP) and -p (PCIe) · E208e-p (external)
Boot	2 × onboard M.2 (SATA or NVMe) · NS204i-u (2 × 480 GB M.2 NVMe, RAID 1)
Media	1 optical drive · 1 half-height internal LTO

Expansion & networking

PCIe	2 × PCIe 5.0 x16 standard (slots 1, 4) · slots 2, 3 via GPU riser kits
OCP	1 × OCP 3.0, PCIe 5.0 x16 (NIC or OROC controller)
Embedded NIC	2 × 1GbE Broadcom BCM5720
NIC options	1GbE to 100GbE, PCIe and OCP 3.0

Accelerators

GPUs	Up to 2 × NVIDIA L4 24 GB or 2 × NVIDIA RTX 4000 Ada · no mixing
Requirements	Redundant Fan Kit for any GPU · L4: riser kits, support kit, 25°C inlet, CPU ≤ 150 W

Power

Flex Slot, up to 2	500 W Platinum · 800 W Platinum · 1000 W Titanium · 1600 W Platinum (200–240 VAC)
Redundancy	1+1 with two identical supplies · no mixing

Ports & video

Front	DisplayPort · 1 × USB 3.2 Gen 1 · iLO service port
Rear	VGA · 2 × USB 3.2 Gen 1 · 2 × 1GbE · dedicated 1GbE iLO · optional serial
Internal	1 × USB 3.2 Gen 1 · 1 × USB 2.0
Video	1920 × 1200 at 60 Hz (32 bpp), 16 MB video memory

Environment & acoustics

Standard operating	10–35 °C at sea level, derated 1.0 °C per 305 m
Extended (approved configs)	5–10 °C and 35–45 °C · A3/A4 needs the Redundant Fan Kit
Operating altitude	3050 m
Acoustics (bystander)	22 dBA idle, all builds · 24 dBA (Entry), 31 dBA (Base SFF), 37 dBA (Performance SFF) operating

Warranty

Standard	3 years parts, 3 years labour, 3 years on-site, next business day

12 — FAQ

ML110 Gen11 questions, answered from the documentation

What is the maximum memory of the HPE ProLiant ML110 Gen11?

1.5 TB, using sixteen 96 GB DDR5-5600 RDIMMs with a 5th Gen Xeon Scalable processor. With a 4th Gen processor the limit is 1.0 TB, from sixteen 64 GB DDR5-4800 RDIMMs. HPE quotes both at 4400 MT/s with two DIMMs per channel, and the 96 GB module is not supported with the Silver 4510 and 4509Y or the Bronze 3508U.

Which processors does the ML110 Gen11 support?

One 4th or 5th Gen Intel Xeon Scalable processor. HPE’s tables list eighteen: eleven 4th Gen parts from the 8-core Bronze 3408U to the 32-core Gold 6421N, and seven 5th Gen parts from the 8-core Bronze 3508U to the 28-core Gold 5512U. TDP ranges from 125 W to 185 W, and three of the listed 4th Gen parts have no option kit.

How many drives does the ML110 Gen11 hold?

Up to sixteen 2.5-inch or eight 3.5-inch SAS/SATA drives in two cages, or four LFF plus eight SFF on the LFF chassis. Two onboard M.2 slots add SATA or NVMe boot drives. There are no NVMe drive bays.

Does the ML110 Gen11 support GPUs?

Yes, up to two, of one type: NVIDIA L4 24 GB cards on the GPU riser kits, or NVIDIA RTX 4000 Ada cards in slots 1 to 3. Every GPU needs the Redundant Fan Kit. With L4s the processor is limited to 150 W TDP and inlet air to 25°C.

How many PCIe slots and what networking does the ML110 Gen11 have?

Two PCIe 5.0 x16 slots as standard and up to four with the two GPU riser kits, plus one OCP 3.0 slot at PCIe 5.0 x16. The OCP slot takes either a network adapter or an OCP RAID controller. Two embedded 1GbE ports and a dedicated iLO port are built in, and adapters run up to 100GbE.

What power supplies does the ML110 Gen11 use?

Up to two hot-plug Flex Slot supplies: Platinum at 500 W, 800 W or 1600 W, or Titanium at 1000 W. Two identical units provide 1+1 redundancy, and different supplies cannot be mixed. The 1600 W unit needs 200–240 VAC.

Can the ML110 Gen11 be rack-mounted, and how big is it?

Yes. As a tower it measures 46.2 cm high, 19.5 cm wide and 58.7 cm deep; with the ML Gen11/Gen12 tower-to-rack conversion kit (P47394-B21) it occupies 5.5U of rack height. The kit ships as a separate package and cannot be factory-integrated. Weight runs from 20.1 kg to 33.2 kg depending on configuration.

How loud is the ML110 Gen11?

HPE measured 22 dBA at the bystander position at idle for all four test builds. Under load its Entry LFF and SFF builds stayed at 24 dBA, the Base SFF build reached 31 dBA and the Performance SFF build 37 dBA. For quiet rooms HPE advises LFF cages, SATA drives and avoiding fast SAS drives, the NS204i-u, 96 GB DIMMs, GPUs and NICs of 100Gb or more.

Should I choose the ML110 Gen11, the ML30 Gen11 or the ML350 Gen11?

The ML30 Gen11 is the entry tower: Xeon 6300 or E-2400, four UDIMM slots and 128 GB. The ML110 moves to Xeon Scalable with sixteen RDIMM slots, OCP 3.0 and two GPUs in one socket. The ML350 Gen11 adds a second socket and 32 DIMM slots.

Is the HPE ProLiant ML110 Gen11 end of life?

HPE’s QuickSpecs give no sign of it. Version 36, dated 13 July 2026, lists no end-of-sale or end-of-support date for the ML110 Gen11; its recent revisions retire obsolete pre-configured model SKUs and individual option part numbers, not the platform. Check the live position with our server end-of-life checker.

Sources & verification

Where these figures come from

HPE ProLiant ML110 Gen11 QuickSpecs (Version 36 - 13-Jul-2026) — Overview, Standard Features (processors, memory, expansion slots, storage controllers, maximum storage, power, interfaces, security, warranty), Configuration Information Step 1, Core Options (processors, memory, power), Additional Options (controllers, drive cages, riser cards, accelerators, networking, boot device, fans, tape, rack kit), Memory population rules, Technical Specifications (dimensions, weight, power, environment, acoustics) and Summary of Changes.
HPE ProLiant ML30 Gen11 QuickSpecs (Version 27 - 03-Aug-2026) — ML30 processor families, DIMM slots and memory ceiling for the family comparison.
HPE ProLiant MicroServer Gen11 QuickSpecs (Version 16 - 03-Aug-2026) — MicroServer processor families and memory ceiling for the family comparison.
HPE ProLiant ML350 Gen11 QuickSpecs (Version 47 - 08-Sep-2026) — ML350 socket count and DIMM slots for the family comparison.
HPE ProLiant DL320 Gen11 QuickSpecs (Version 41 - 03-Aug-2026) — DL320 form factor and processor line for the family comparison.

Specifications are extracted from HPE’s published documents and independently re-checked line by line. Configurations are quote-based; availability and exact options are confirmed at quotation. Last reviewed 2026-09-11.

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The ML110 Gen11 at a glance

Strengths

Watch-outs

18 supported processors, mapped

Processor landscape — cores × TDP

Processor explorer

16 DDR5 DIMM slots

Capacity with every slot filled

Rated memory speed

7 drive-cage kits, up to 16 bays

Headline layouts

Controllers & boot

Every documented drive-cage kit

GPUs, PCIe and networking

NVIDIA L4 24GB PCIe Accelerator for HPE

NVIDIA RTX 4000 Ada Graphics Accelerator for HPE

I/O topology

Network adapters HPE lists

4 power supplies, 500–1,600 W

Run it, secure it, choose the OS

Management

Security

Operating systems

How the ML110 Gen11 compares with its family

Four builds that suit the ML110 Gen11

Single-socket hypervisor with 512 GB

Two NVIDIA L4 cards for on-site inference

Quiet LFF file server following HPE’s acoustic advice

SQL server with mirrored NS204i-u boot

When a refurbished ProLiant makes more sense

HPE ProLiant ML350 Gen10

HPE ProLiant DL325 Gen10 Plus

HPE ProLiant DL380 Gen10

HPE ProLiant ML110 Gen11 specifications

Chassis & cooling

Processor

Memory

Storage

Expansion & networking

Accelerators

Power

Ports & video

Environment & acoustics

Warranty

ML110 Gen11 questions, answered from the documentation

Where these figures come from

Buy & configure

Guides & family

Plan the deployment

Support & lifecycle

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