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Technical data sheet · ProLiant Gen11 · 4U tower (5U racked), dual-socket

HPE ProLiant ML350 Gen11Specifications, configurations & comparisons

The ProLiant ML350 Gen11 is HPE’s two-socket tower for 4th and 5th Gen Xeon Scalable, sold as an LFF or an SFF configure-to-order chassis and convertible to a 5U rack server. This data sheet sets out what the QuickSpecs allow — up to 64 cores per socket, 32 DDR5 slots, three front drive boxes, ten PCIe 5.0 slots, internal LTO tape and five NVIDIA GPU models — and the fan kits each option drags in.

Tower / 5U Rack1 or 2 sockets4th Gen Xeon Scalable5th Gen Xeon ScalableHPE iLO 6
64cores per CPU128 per server · 5th Gen Xeon Scalable
8.0TBDDR5 maximum32 DIMM slots
24drive bays4 drive-cage kits
8GPUs5 accelerators listed
2,200Wlargest PSU6 supply options
57processor SKUs2 families
Configure an ML350 Gen11 →Get a UK quoteRefurbished alternatives ↓

Every figure checked against the HPE ProLiant ML350 Gen11 QuickSpecs (Version 47 - 08-Sep-2026)

HPE ProLiant ML350 Gen11 tower server, front view with bezel fitted, feet extended and ProLiant ML350 Gen11 lettering on the lower bezel

Image: Hewlett Packard Enterprise

Form factor
Tower / 5U Rack · 2 sockets
Processors
4th Gen Xeon · 5th Gen Xeon
Memory
32 × DDR5 RDIMM · up to 8.0 TB
Drive bays
Up to 24 · 4 drive-cage kits
Expansion
10 × PCIe · 2 × OCP 3.0
GPUs
Up to 8 · 5 listed
Boot
NS204i · 4 boot options
Management
HPE iLO 6
01 — Overview

The ML350 Gen11 at a glance

Our read of HPE’s documentation: where the ML350 Gen11 is strong, and the limits worth knowing before you spec one.

Strengths

  • Two ways to start: the LFF chassis mixes 4LFF and 8SFF boxes up to three, while the SFF chassis stacks 8SFF boxes or swaps to one factory-fitted x4 NVMe or 12-bay E3.S cage.
  • Fifty-seven Xeon Scalable processors appear in HPE’s tables, from the 8-core Bronze 3408U to the 64-core Platinum 8592+; HPE rates each at 80 PCIe 5.0 lanes but holds the Bronze 3408U and 3508U to PCIe Gen4.
  • Up to ten PCIe 5.0 slots on three risers — eight full-height, full-length and two half-height — plus two OCP 3.0 slots.
  • An LTO-8 or LTO-9 tape drive can live inside the chassis in Box 1, and the tertiary riser powers it even on a one-processor server.
  • HPE declares 3.9 to 4.1 B at idle and 4.1 to 4.2 B operating for its five test builds — 25 to 26 dBA at the bystander position.

Watch-outs

  • The printed 8.0 TB memory maximum assumes 256 GB DIMMs, yet the largest kit in HPE’s option list is 128 GB, which gives 4 TB across 32 slots.
  • The x4 NVMe and 12EDSFF cages are factory-only, replace the default cage and exclude every other cage, so those builds stop at 8 NVMe or 12 E3.S drives.
  • A 4th Gen (x4xx) server cannot be field-upgraded to 5th Gen (x5xx) processors, and the two sockets must carry the same model.
  • Any GPU brings both the Redundant and Second CPU fan kits, x16 cards need 2x16 risers, and the External GPU Fan Kit blanks the rear of the primary and secondary risers.
  • The 12EDSFF cage demands two processors and caps the inlet temperature at 25 °C.
Processors57 SKUs
Cores / CPU8–64
DIMM slots32
Drive-cage kits4
Max bays24
GPUsup to 8
PSU options6 · to 2,200 W
02 — Processors

57 supported processors, mapped

HPE’s tables name 57 Xeon Scalable processors for the ML350 Gen11 — 32 from the fourth generation and 25 from the fifth — with core counts from 8 to 64 and TDPs between 125 W and 350 W. Forty-three have HPE option kits; the other 14 appear only in the standard-features table. The landscape and explorer below plot each one.

Processor landscape — cores × TDP

57 SKUs · 2 families
HPE ProLiant ML350 Gen11: every supported processor by cores and TDP0816243240485664100 W150 W200 W250 W300 W350 WCores per processorIntel Xeon Platinum 8490H — 60 cores · 350 W · 1.9 GHz base · 112.5 MB cache · DDR5-4800Intel Xeon Platinum 8480+ — 56 cores · 350 W · 2 GHz base · 105 MB cache · DDR5-4800Intel Xeon Platinum 8470 — 52 cores · 350 W · 2 GHz base · 105 MB cache · DDR5-4800Intel Xeon Platinum 8470N — 52 cores · 300 W · 1.7 GHz base · 97.5 MB cache · DDR5-4800Intel Xeon Platinum 8468 — 48 cores · 350 W · 2.1 GHz base · 105 MB cache · DDR5-4800Intel Xeon Platinum 8468V — 48 cores · 330 W · 2.4 GHz base · 97.5 MB cache · DDR5-4800Intel Xeon Platinum 8458P — 44 cores · 350 W · 2.7 GHz base · 82.5 MB cache · DDR5-4800Intel Xeon Platinum 8460Y+ — 40 cores · 300 W · 2 GHz base · 105 MB cache · DDR5-4800Intel Xeon Platinum 8452Y — 36 cores · 300 W · 2 GHz base · 67.5 MB cache · DDR5-4800Intel Xeon Gold 6430 — 32 cores · 270 W · 2.1 GHz base · 60 MB cache · DDR5-4400Intel Xeon Gold 6454S — 32 cores · 270 W · 2.2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6448H — 32 cores · 250 W · 2.4 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6414U — 32 cores · 250 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6448Y — 32 cores · 225 W · 2.1 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6438Y+ — 32 cores · 205 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6438N — 32 cores · 205 W · 2 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6421N — 32 cores · 185 W · 1.8 GHz base · 60 MB cache · DDR5-4400Intel Xeon Gold 5420+ — 28 cores · 205 W · 2 GHz base · 52.5 MB cache · DDR5-4400Intel Xeon Gold 6442Y — 24 cores · 225 W · 2.6 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 6418H — 24 cores · 185 W · 2.1 GHz base · 60 MB cache · DDR5-4800Intel Xeon Gold 5418Y — 24 cores · 185 W · 2 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 5411N — 24 cores · 165 W · 1.9 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 5418N — 24 cores · 165 W · 1.8 GHz base · 45 MB cache · DDR5-4000Intel Xeon Silver 4416+ — 20 cores · 165 W · 2 GHz base · 37.5 MB cache · DDR5-4000Intel Xeon Gold 6416H — 18 cores · 165 W · 2.2 GHz base · 45 MB cache · DDR5-4800Intel Xeon Platinum 8444H — 16 cores · 270 W · 2.9 GHz base · 45 MB cache · DDR5-4800Intel Xeon Gold 6426Y — 16 cores · 185 W · 2.5 GHz base · 37.5 MB cache · DDR5-4800Intel Xeon Gold 5416S — 16 cores · 150 W · 2 GHz base · 30 MB cache · DDR5-4400Intel Xeon Silver 4410Y — 12 cores · 150 W · 2 GHz base · 30 MB cache · DDR5-4000Intel Xeon Gold 6434 — 8 cores · 195 W · 3.7 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Gold 5415+ — 8 cores · 150 W · 2.9 GHz base · 22.5 MB cache · DDR5-4400Intel Xeon Bronze 3408U — 8 cores · 125 W · 1.8 GHz base · 22.5 MB cache · DDR5-4000Intel Xeon Platinum 8592+ — 64 cores · 350 W · 1.9 GHz base · 320 MB cache · DDR5-5600Intel Xeon Platinum 8592V — 64 cores · 330 W · 2 GHz base · 320 MB cache · DDR5-4800Intel Xeon Platinum 8580 — 60 cores · 350 W · 2 GHz base · 300 MB cache · DDR5-5600Intel Xeon Platinum 8581V — 60 cores · 270 W · 2 GHz base · 300 MB cache · DDR5-4800Intel Xeon Platinum 8570 — 56 cores · 350 W · 2.1 GHz base · 300 MB cache · DDR5-5600Intel Xeon Platinum 8568Y+ — 48 cores · 350 W · 2.3 GHz base · 300 MB cache · DDR5-5600Intel Xeon Platinum 8558P — 48 cores · 350 W · 2.7 GHz base · 260 MB cache · DDR5-5600Intel Xeon Platinum 8558 — 48 cores · 330 W · 2.1 GHz base · 260 MB cache · DDR5-5200Intel Xeon Platinum 8558U — 48 cores · 300 W · 2 GHz base · 260 MB cache · DDR5-4800Intel Xeon Gold 6554S — 36 cores · 270 W · 2.2 GHz base · 180 MB cache · DDR5-5200Intel Xeon Gold 6530 — 32 cores · 270 W · 2.1 GHz base · 160 MB cache · DDR5-4800Intel Xeon Gold 6548Y+ — 32 cores · 250 W · 2.5 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6548N — 32 cores · 250 W · 2.8 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6538Y+ — 32 cores · 225 W · 2.2 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 6538N — 32 cores · 205 W · 2.1 GHz base · 60 MB cache · DDR5-5200Intel Xeon Gold 5520+ — 28 cores · 205 W · 2.2 GHz base · 52.5 MB cache · DDR5-4800Intel Xeon Gold 6542Y — 24 cores · 250 W · 2.9 GHz base · 60 MB cache · DDR5-5200Intel Xeon Silver 4516Y+ — 24 cores · 185 W · 2.2 GHz base · 45 MB cache · DDR5-4400Intel Xeon Gold 6526Y — 16 cores · 195 W · 2.8 GHz base · 37.5 MB cache · DDR5-5200Intel Xeon Silver 4514Y — 16 cores · 150 W · 2 GHz base · 30 MB cache · DDR5-4400Intel Xeon Silver 4510 — 12 cores · 150 W · 2.4 GHz base · 30 MB cache · DDR5-4400Intel Xeon Gold 6534 — 8 cores · 195 W · 3.9 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Gold 5515+ — 8 cores · 165 W · 3.2 GHz base · 22.5 MB cache · DDR5-4800Intel Xeon Silver 4509Y — 8 cores · 125 W · 2.6 GHz base · 22.5 MB cache · DDR5-4400Intel Xeon Bronze 3508U — 8 cores · 125 W · 2.1 GHz base · 22.5 MB cache · DDR5-44008592+64 cores — the top SKU8581V4.5 W/core — most efficient
4th Gen Xeon Scalable 325th Gen Xeon Scalable 25Bubble size = L3 cache · hover a bubble for the full SKU

Processor explorer

filter · sort · compare
ProcessorCores / threadsBaseL3 cacheTDPW / coreMemory
Intel Xeon Platinum 8592+641.9 GHz320 MB350 W5.5DDR5-5600
Intel Xeon Platinum 8592V642 GHz320 MB330 W5.2DDR5-4800
Intel Xeon Platinum 8490H601.9 GHz112.5 MB350 W5.8DDR5-4800
Intel Xeon Platinum 8580602 GHz300 MB350 W5.8DDR5-5600
Intel Xeon Platinum 8581V602 GHz300 MB270 W4.5DDR5-4800
Intel Xeon Platinum 8480+562 GHz105 MB350 W6.3DDR5-4800
Intel Xeon Platinum 8570562.1 GHz300 MB350 W6.3DDR5-5600
Intel Xeon Platinum 8470522 GHz105 MB350 W6.7DDR5-4800
Intel Xeon Platinum 8470N521.7 GHz97.5 MB300 W5.8DDR5-4800
Intel Xeon Platinum 8468482.1 GHz105 MB350 W7.3DDR5-4800
Intel Xeon Platinum 8468V482.4 GHz97.5 MB330 W6.9DDR5-4800
Intel Xeon Platinum 8568Y+482.3 GHz300 MB350 W7.3DDR5-5600
Intel Xeon Platinum 8558P482.7 GHz260 MB350 W7.3DDR5-5600
Intel Xeon Platinum 8558482.1 GHz260 MB330 W6.9DDR5-5200
Intel Xeon Platinum 8558U482 GHz260 MB300 W6.3DDR5-4800
Intel Xeon Platinum 8458P442.7 GHz82.5 MB350 W8.0DDR5-4800
Intel Xeon Platinum 8460Y+402 GHz105 MB300 W7.5DDR5-4800
Intel Xeon Platinum 8452Y362 GHz67.5 MB300 W8.3DDR5-4800
Intel Xeon Gold 6554S362.2 GHz180 MB270 W7.5DDR5-5200
Intel Xeon Gold 6430322.1 GHz60 MB270 W8.4DDR5-4400
Intel Xeon Gold 6454S322.2 GHz60 MB270 W8.4DDR5-4800
Intel Xeon Gold 6448H322.4 GHz60 MB250 W7.8DDR5-4800
Intel Xeon Gold 6414U322 GHz60 MB250 W7.8DDR5-4800
Intel Xeon Gold 6448Y322.1 GHz60 MB225 W7.0DDR5-4800
Intel Xeon Gold 6438Y+322 GHz60 MB205 W6.4DDR5-4800
Intel Xeon Gold 6438N322 GHz60 MB205 W6.4DDR5-4800
Intel Xeon Gold 6421N321.8 GHz60 MB185 W5.8DDR5-4400
Intel Xeon Gold 6530322.1 GHz160 MB270 W8.4DDR5-4800
Intel Xeon Gold 6548Y+322.5 GHz60 MB250 W7.8DDR5-5200
Intel Xeon Gold 6548N322.8 GHz60 MB250 W7.8DDR5-5200
Intel Xeon Gold 6538Y+322.2 GHz60 MB225 W7.0DDR5-5200
Intel Xeon Gold 6538N322.1 GHz60 MB205 W6.4DDR5-5200
Intel Xeon Gold 5420+282 GHz52.5 MB205 W7.3DDR5-4400
Intel Xeon Gold 5520+282.2 GHz52.5 MB205 W7.3DDR5-4800
Intel Xeon Gold 6442Y242.6 GHz60 MB225 W9.4DDR5-4800
Intel Xeon Gold 6418H242.1 GHz60 MB185 W7.7DDR5-4800
Intel Xeon Gold 5418Y242 GHz45 MB185 W7.7DDR5-4400
Intel Xeon Gold 5411N241.9 GHz45 MB165 W6.9DDR5-4400
Intel Xeon Gold 5418N241.8 GHz45 MB165 W6.9DDR5-4000
Intel Xeon Gold 6542Y242.9 GHz60 MB250 W10.4DDR5-5200
Intel Xeon Silver 4516Y+242.2 GHz45 MB185 W7.7DDR5-4400
Intel Xeon Silver 4416+202 GHz37.5 MB165 W8.3DDR5-4000
Intel Xeon Gold 6416H182.2 GHz45 MB165 W9.2DDR5-4800
Intel Xeon Platinum 8444H162.9 GHz45 MB270 W16.9DDR5-4800
Intel Xeon Gold 6426Y162.5 GHz37.5 MB185 W11.6DDR5-4800
Intel Xeon Gold 5416S162 GHz30 MB150 W9.4DDR5-4400
Intel Xeon Gold 6526Y162.8 GHz37.5 MB195 W12.2DDR5-5200
Intel Xeon Silver 4514Y162 GHz30 MB150 W9.4DDR5-4400
Intel Xeon Silver 4410Y122 GHz30 MB150 W12.5DDR5-4000
Intel Xeon Silver 4510122.4 GHz30 MB150 W12.5DDR5-4400
Intel Xeon Gold 643483.7 GHz22.5 MB195 W24.4DDR5-4800
Intel Xeon Gold 5415+82.9 GHz22.5 MB150 W18.8DDR5-4400
Intel Xeon Bronze 3408U81.8 GHz22.5 MB125 W15.6DDR5-4000
Intel Xeon Gold 653483.9 GHz22.5 MB195 W24.4DDR5-4800
Intel Xeon Gold 5515+83.2 GHz22.5 MB165 W20.6DDR5-4800
Intel Xeon Silver 4509Y82.6 GHz22.5 MB125 W15.6DDR5-4400
Intel Xeon Bronze 3508U82.1 GHz22.5 MB125 W15.6DDR5-4400
  • Seven parts are single-socket only: the U-series 6414U, 3408U and 3508U, plus the 6421N, 5411N, 8581V and 8558U.
  • Under 195 W a processor takes the Standard heat sink (P47223-B21); at 195 W and above it takes the Performance heat sink (P47224-B21), and from 300 W the Redundant and Second CPU fan kits too.
  • The Bronze 3408U and 3508U are limited to PCIe Gen4, and Intel VROC NVMe is not available with the 4510, 4509Y or 3508U.
  • Processors talk over UPI at 16 GT/s; the explorer shows how many links each SKU has.
  • Processor option kits contain only the processor — heat sinks and fans are separate lines on the order.
03 — Memory

32 DIMM slots, 16 per processor

Each processor controls eight DDR5 channels with two RDIMM slots per channel, so a two-socket ML350 Gen11 has 32 slots and a single-socket one can use half of them. DDR5-4800 kits go with 4th Gen processors and DDR5-5600 kits with 5th Gen; the processor’s own rating sets the speed the memory finally runs at.

Capacity with every slot filled

by DIMM size
16 GB512 GB32 GB1 TB64 GB2 TB96 GB3 TB8 or 16 per CPU128 GB4 TB32 slots · 16 per processor · each tick = one DIMM

Rated memory speed

from the processor table
Processor familyUp to
4th Gen Xeon Scalable4800 MT/s
5th Gen Xeon Scalable5600 MT/s
  • Per socket, HPE permits 1, 2, 4, 6, 8, 12 or 16 DIMMs; the 96 GB kits are limited to 8 or 16 per processor.
  • The 8.0 TB maximum HPE prints — 32 × 256 GB at 4400 MT/s, two per channel — depends on a 256 GB DIMM the option list doesn’t offer. With the 128 GB kits that are listed, the ceiling is 4 TB.
  • The fan and population rules still mention 256 GB DIMMs: 25 °C maximum inlet without the redundant fan configuration, 30 °C with it.
  • In HPE’s pre-configured models the 12-core Silver 4410Y runs 32 GB DDR5-4800 DIMMs at 4000 MT/s, a processor limit.
  • Advanced ECC is the only memory protection scheme listed.
04 — Storage

4 drive-cage kits, up to 24 bays

Choose the chassis first. The LFF CTO server arrives with one 4LFF box and can add two more LFF or SFF boxes; the SFF CTO server arrives with one tri-mode 8SFF box and adds up to two more, or trades it for a factory-fitted x4 NVMe or 12-bay E3.S cage. The layouts below are complete maximums; the kit chart lists every cage.

Headline layouts

front panel view

Front panel

Three 8SFF x1 U.3 tri-mode boxes: 24 small drives, SAS, SATA or x1 NVMe. HPE’s storage table reaches 368.64 TB raw here with 15.36 TB SSDs.

SAS/SATANVMeSAS/SATA + NVMe

Controllers & boot

  • HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device — Boot. RAID1-protected hot-plug M.2 NVMe boot device; requires Second CPU Fan Kit (P47902-B21) and NS204i-u Enablement Kit (P48403-B21); with NS204i-u the embedded controller supports up to 8 SATA drives in the LFF CTO; capacity not printed in this option name
  • HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device — Boot. RAID1-protected hot-plug M.2 NVMe boot device; requires Second CPU Fan Kit (P47902-B21) and NS204i-u Enablement Kit (P48403-B21); with NS204i-u the embedded controller supports up to 8 SATA drives in the LFF CTO
  • HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device — Boot. RAID1-protected hot-plug M.2 NVMe boot device; requires Second CPU Fan Kit (P47902-B21) and NS204i-u Enablement Kit (P48403-B21); with NS204i-u the embedded controller supports up to 8 SATA drives in the LFF CTO; self-encrypting
  • Intel VROC SATA for HPE ProLiant Gen11 (embedded) — Software RAID. Embedded controller with 2 SlimSAS ports; SATA RAID 0/1/5/10 up to 12 (4+4+4) LFF or 8 SFF (8 (4+4) LFF when NS204i-u fitted); UEFI mode only; off by default; SATA only - an additional controller is required for SAS drives
  • Intel Virtual RAID on CPU RAID 1 FIO Software for HPE — Software RAID. Intel VROC NVMe; RAID 1; NVMe SSDs only (no PCIe card support); UEFI only; not supported with 4510, 4509Y, 3508U
  • Intel Virtual RAID on CPU RAID 1 E-RTU for HPE — Software RAID. RAID 1; field-deployment (BTO) equivalent of S3Q19A
  • Intel Virtual RAID on CPU Premium FIO Software for HPE — Software RAID. Intel VROC NVMe; RAID 0/1/5/10; NVMe SSDs only; UEFI only
  • Intel Virtual RAID on CPU Premium E-RTU for HPE — Software RAID. RAID 0/1/5/10; field-deployment (BTO) equivalent of R7J57A
  • HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device (P48183-B21) — boot
  • HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device (P81160-B21) — boot
  • HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device (P81162-B21) — boot
  • HPE ProLiant ML350 Gen11 NS204i-u Enablement Kit (P48403-B21) — boot
All 16 controllers and 4 boot options
  • HPE Smart Array E208e-p SR Gen10 (8 External Lanes/No Cache) 12G SAS PCIe Plug-in Controller — RAID. Listed under 'Essential RAID Controllers'; PCIe; up to 8 SAS/SATA drives (external); uses a different RAID configuration tool from the MR controllers
  • HPE MR216i-o Gen11 x16 Lanes without Cache OCP SPDM Storage Controller — RAID. OCP (OROC, Slot 14 OCP 1 only); does not occupy a PCIe slot; up to 16 SAS/SATA/NVMe drives, RAID 0/1/10
  • HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Plug-in Storage Controller — RAID. PCIe plug-in; no per-option notes printed
  • HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller — RAID, 4GB cache. OCP (OROC, Slot 14 OCP 1); does not occupy a PCIe slot; up to 8 SAS/SATA/NVMe drives; requires HPE 96W Smart Storage Battery (P01367-B21) or HPE Smart Hybrid Capacitor (P02381-B21 or P65042-B21)
  • HPE MR408i-p Gen11 x8 Lanes 4GB Cache PCI SPDM Plug-in Storage Controller — RAID, 4GB cache. PCIe plug-in; up to 8 SAS/SATA/NVMe drives; requires HPE 96W Smart Storage Battery (P01367-B21) or HPE Smart Hybrid Capacitor (P02381-B21 or P65042-B21)
  • HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller — RAID, 8GB cache. OCP (OROC, Slot 14 OCP 1); does not occupy a PCIe slot; up to 16 SAS/SATA/NVMe drives; requires HPE 96W Smart Storage Battery (P01367-B21) or HPE Smart Hybrid Capacitor (P02381-B21 or P65042-B21)
  • HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Plug-in Storage Controller — RAID, 8GB cache. PCIe plug-in; up to 16 SAS/SATA/NVMe drives; requires HPE 96W Smart Storage Battery (P01367-B21) or HPE Smart Hybrid Capacitor (P02381-B21 or P65042-B21)
  • HPE SR932i-p Gen11 x32 Lanes 8GB Wide Cache PCI SPDM Plug-in Storage Controller — RAID, 8GB cache. PCIe plug-in; up to 32 SAS/SATA/NVMe drives; requires HPE 96W Smart Storage Battery (P01367-B21) or HPE Smart Hybrid Capacitor (P02381-B21 or P65042-B21); requires PCIe x16 (2x16 Primary FIO Riser P48406-B21 or 2x16 Secondary Riser P47238-B21); required for controller mode of the 8SFF x4 U.3 cage (P47218-B21)
  • Hybrid LFF-plus-SFF builds start from the LFF CTO server (P48404-B21).
  • Embedded Intel VROC SATA handles up to 12 LFF drives in groups of four, or 8 SFF drives; with an NS204i-u fitted it drops to 8. It is disabled by default and works in UEFI mode only.
  • For VROC NVMe, each socket has four x8 PCIe 5.0 connectors that cable up to eight x4 bays directly; arrays need a RAID 1 or Premium licence on the order.
  • MegaRAID (MR) and SmartRAID (SR) internal controllers can’t share a server, and OCP-form controllers fit only Slot 14 (OCP 1).
  • The NS204i-u boot device needs the ML350 Gen11 NS204i-u Enablement Kit (P48403-B21) and the Second CPU Fan Kit.
  • Internal tape takes Box 1 and needs the tertiary riser (P49693-B21), the LTO support kit (P62309-B21) and a free port on an MR216i-o/p or MR408i-o.
  • For the E3.S build the storage table prints 183.6 TB as “12 × 15.3 TB”; HPE’s drive list has 15.36 TB E3.S parts but none of 15.3 TB, and twelve 15.36 TB drives would make 184.32 TB.

Every documented drive-cage kit

4 with drive bays
HPE ProLiant ML350 Gen11 8SFF x1 U.3 Tri-Mode Driv…HPE ProLiant ML350 Gen11 8SFF x1 U.3 Tri-Mode Drive Cage Kit8HPE ProLiant ML350 Gen11 8SFF x4 U.3 Tri-Mode FIO …HPE ProLiant ML350 Gen11 8SFF x4 U.3 Tri-Mode FIO Drive Cage Kit8HPE ProLiant ML350 Gen11 4LFF SAS/SATA Basic Drive…HPE ProLiant ML350 Gen11 4LFF SAS/SATA Basic Drive Cage Kit4HPE ProLiant ML350 Gen11 12EDSFF FIO Drive Cage KitHPE ProLiant ML350 Gen11 12EDSFF FIO Drive Cage Kit12Bays · solid = front · dashed = rear · brighter = NVMe-only
2.5-inch3.5-inchEDSFF (E1.S / E3.S)
05 — Accelerators & I/O

GPUs, PCIe and networking

Five NVIDIA cards are listed, and most of their rules concern cooling. Every GPU needs the Redundant and Second CPU fan kits, x16 cards need a 2x16 riser holding two cards each, and HPE’s inlet-temperature table falls as drive boxes are added — only the L4 and RTX A1000 carry a 30 °C rating in every one of the five storage columns without HPE’s limited two-processor, two-GPU setup. Up to 8 × RTX A1000 (x8), 4 × L40, A16 or L4, or 2 × L40S (slots 2 and 6, processors ≤ 190 W).

NVIDIA L40 48GB PCIe Accelerator for HPE

48GB · 4

NVIDIA L40S 48GB PCIe Accelerator

48GB · 2

NVIDIA A16 64GB PCIe Non-CEC Accelerator for HPE

64GB · 4

NVIDIA L4 24GB PCIe Accelerator for HPE

24GB · 4

NVIDIA RTX A1000 8GB PCIe Accelerator for HPE

8GB · 8

I/O topology

80 lanes per CPU
CPU 180 × PCIe 5.08 ch · 16 DIMMCPU 280 × PCIe 5.08 ch · 16 DIMMUPI · 16 GT/sPrimary riser (CPU 1)4 × x8 or 2 × x16 · full lengthSecondary + tertiary (CPU 2)4 × x8 / 2 × x16 + 2 × x8 HHHLSlot 14 · OCP 1x8 PCIe 5.0 · OROC controllersSlot 15 · OCP 2default NIC slot · WOL, shared NIC

HPE gives each processor 80 PCIe 5.0 lanes (Gen4 on the two Bronze parts) and eight DDR5 channels. The primary riser belongs to processor 1; the secondary and tertiary risers need processor 2, so a single-socket ML350 Gen11 has only the primary riser’s four x8 or two x16 slots.

Network adapters HPE lists

29 options
AdapterPortsForm
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE4 × 1GbEOCP 3.0
Intel I350-T4 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE4 × 1GbEOCP 3.0
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter for HPE2 × 10GbEOCP 3.0
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T OCP3 Adapter for HPE2 × 10GbEOCP 3.0
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE2 × 10/25GbEOCP 3.0
Mellanox MCX631432AS-ADAI Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE2 × 10/25GbEOCP 3.0
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE2 × 10/25GbEOCP 3.0
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 OCP3 Adapter for HPE4 × 10/25GbEOCP 3.0
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 OCP3 Adapter for HPE2 × 100GbEOCP 3.0
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE4 × 1GbEPCIe
Intel I350-T4 Ethernet 1Gb 4-port BASE-T Adapter for HPE4 × 1GbEPCIe
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE2 × 10GbEPCIe
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE2 × 10GbEPCIe
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE2 × 10/25GbEPCIe
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE4 × 10/25GbEPCIe
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE2 × 10/25GbEPCIe
Mellanox MCX631102AS-ADAT Ethernet 10/25Gb 2-port SFP28 Adapter for HPE2 × 10/25GbEPCIe
Intel E810-XXVDA4 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE4 × 10/25GbEPCIe
NVIDIA Ethernet 10/25Gb 2-port SFP28 NVMe-oF Crypto Adapter for HPE2 × 10/25GbEPCIe
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 Adapter for HPE2 × 100GbEPCIe
NVIDIA Ethernet 100Gb 2-port NVMe-oF Offload Adapter for HPE2 × 100GbEPCIe
HPE SN1610E 32Gb 1-port Fibre Channel Host Bus Adapter1 × 32Gb Fibre ChannelPCIe
HPE SN1610E 32Gb 2-port Fibre Channel Host Bus Adapter2 × 32Gb Fibre ChannelPCIe
HPE SN1700E 64Gb 1-port Fibre Channel Host Bus Adapter1 × 64Gb Fibre ChannelPCIe
HPE SN1700E 64Gb 2-port Fibre Channel Host Bus Adapter2 × 64Gb Fibre ChannelPCIe
HPE SN1610Q 32Gb 1-port Fibre Channel Host Bus Adapter1 × 32Gb Fibre ChannelPCIe
HPE SN1610Q 32Gb 2-port Fibre Channel Host Bus Adapter2 × 32Gb Fibre ChannelPCIe
HPE SN1700Q 64Gb 1-port Fibre Channel Host Bus Adapter1 × 64Gb Fibre ChannelPCIe
HPE SN1700Q 64Gb 2-port Fibre Channel Host Bus Adapter2 × 64Gb Fibre ChannelPCIe
  • Slots 1 to 8 are full-height, full-length with x16 connectors; slots 9 and 10 on the 2x8 tertiary riser are half-height, half-length.
  • The 2x16 primary riser (P48406-B21) is a factory-only option that replaces the default 4x8 riser.
  • The tertiary riser occupies two of processor 2’s MCIO connectors; without that processor its slots have no function, although it still powers an internal LTO drive.
  • A one-processor server needs the OCP1 Enablement Kit for an x16 NIC in Slot 14, and any order with two OCP adapters needs the OCP2 Enablement Kit.
  • Nothing is embedded for networking; the CTO default is a Broadcom BCM5719 four-port 1 Gb OCP3 adapter.
06 — Power & cooling

6 power supplies, 500–2,200 W

One or two HPE Flex Slot hot-plug supplies, never two different models. Of the six on offer, three are Platinum (500 W, 800 W, 1600 W), two are Titanium (1000 W and 1800–2200 W) and one is a 1600 W supply for −48 V DC.

05001000150020002500500 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; rated 500W at 100 VAC / 240 VAC (and 240 VDC input for China only); support limited to a single 125W TDP processor configuration500Platinum800 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; rated 800W at 100 VAC / 240 VAC (and 240 VDC input for China only)800Platinum1000 W Titanium — HPE Flex Slot family; 96% power efficiency; rated 1000W at 100 VAC / 240 VAC; named 'Low Halogen' in Standard Features but not in the option list; listed as EU-ErP-compliant (96%) part number1000Titanium1600 W null — HPE Flex Slot family; -48VDC input; rated 1600W at 40 / 48 / 72 VDC; requires HPE 1600W -48VDC Power Cable Lug Kit (P36877-B21); no efficiency tier printed (see notes for a contradictory 94%/277VAC/380VDC note printed under this PSU)1600DC1600 W Platinum — HPE Flex Slot family; 94% power efficiency; Low Halogen; 200-240 VAC high line input only; rated 1600W at 240 VAC (and 240 VDC for China only)1600Platinum2200 W Titanium — HPE Flex Slot family; '1800W-2200W' unit - 1799W at 200 VAC, 2200W at 240 VAC; 96% power efficiency; 200-240 VAC high line only; listed as EU-ErP-compliant (96%) part number2200TitaniumWatts · dashed line = output at 100–120 V low line
AC277 VAC / HVDC
  • The 500 W supply is supported only with a single 125 W processor.
  • Both the 1600 W Platinum and the 1800–2200 W Titanium need 200–240 V AC; the larger unit gives 1799 W at 200 V AC and 2200 W at 240 V AC.
  • Under the −48 V DC unit the option list also mentions 277 V AC and 380 V DC input, while its name, its 40–72 V DC rating and its lug-kit requirement all describe a DC supply.
  • Maximum heat load runs from 1,832 BTU/hr (500 W at 240 V AC) to 7,962 BTU/hr (1800–2200 W at 240 V AC).
  • Three non-hot-plug system fans are standard, and a second processor needs the Second CPU Fan Kit as the fourth fan.
07 — Management, security & OS

Run it, secure it, choose the OS

Management

  • HPE iLO 6 (iLO 6 ASIC) with Intelligent Provisioning
  • HPE Compute Ops Management subscription included
  • iLO Advanced and HPE OneView Advanced optional
  • iLO RESTful API (Redfish) · Active Health System · Smart Update
  • Dedicated 1 Gb rear iLO port · front iLO service port

Security

  • Immutable Silicon Root of Trust · UEFI Secure Boot and Secure Start
  • TPM 2.0
  • FIPS 140-3 validation and Common Criteria listed as in progress for iLO 6
  • Signed firmware updates, secure recovery and firmware rollback
  • Front bezel key lock (tower and rack) · padlock and Kensington slots
  • Chassis intrusion detection optional

Operating systems

  • The QuickSpecs lists no operating-system versions; HPE publishes OS and hypervisor certification in its Servers Support & Certification Matrices
  • UEFI Class 3 · TPM 2.0 and NVMe boot in UEFI boot mode
  • Redfish Secure Boot key management · old VMware Secure Boot key retirement
08 — Compare

How the ML350 Gen11 compares with its family

Next to the ML350 Gen11 sit its Xeon 6 successor, the ML350 Gen12; HPE’s single-socket ML110 Gen11, ML30 Gen11 and MicroServer Gen11 towers; and the DL380 Gen11, the 2U rack server built on the same 4th and 5th Gen Xeon Scalable processors. Every bar is drawn from that model’s spec file.

ML350 Gen11ML350 Gen12ML110 Gen11ML30 Gen11MicroServer Gen11DL380 Gen11Cores / CPUML350 Gen11: 6464ML350 Gen12: 8686ML110 Gen11: 3232ML30 Gen11: 1212MicroServer Gen11: 1212DL380 Gen11: 6464DIMM slotsML350 Gen11: 3232ML350 Gen12: 3232ML110 Gen11: 1616ML30 Gen11: 44MicroServer Gen11: 44DL380 Gen11: 3232Max memoryML350 Gen11: 8 TB8ML350 Gen12: 8 TB8ML110 Gen11: 1.5 TB1.5ML30 Gen11: 0.125 TB0.125MicroServer Gen11: 0.125 TB0.125DL380 Gen11: 8 TB8Max drive baysML350 Gen11: 2424ML350 Gen12: 2424ML110 Gen11: 1616ML30 Gen11: 88MicroServer Gen11: 44DL380 Gen11: 3636Max GPUsML350 Gen11: 88ML350 Gen12: 88ML110 Gen11: 22ML30 Gen11: 00MicroServer Gen11: 11DL380 Gen11: 88Largest PSUML350 Gen11: 2,200 W2,200ML350 Gen12: 2,200 W2,200ML110 Gen11: 1,600 W1,600ML30 Gen11: 1,000 W1,000MicroServer Gen11: 330 W330DL380 Gen11: 2,200 W2,200
This modelSiblings and successorEach value from that model’s own verified spec file · bars scale per column
ML350 Gen12 data sheetML110 Gen11 data sheetML30 Gen11 data sheetMicroServer Gen11 data sheetDL380 Gen11 data sheetDell PowerEdge T560 data sheetLenovo ThinkSystem ST650 V3 data sheet
09 — Use cases

Four builds that suit the ML350 Gen11

Four ML350 Gen11 builds, each made only of parts the configurator accepts for this tower, opening pre-filled when you follow the link. The configurator places one of each drive cage and two power supplies, so any extra boxes, fan kits, risers or enablement and cable kits HPE requires are added on the quote.

Office virtualisation

Two-socket Hyper-V tower for a branch

Two 24-core Gold 6542Y processors give 48 cores and 1 TB of DDR5 for a branch’s virtual machines in one box; the 6542Y is rated at 5200 MT/s, so the DDR5-5600 DIMMs run at that speed. Eight SAS SSDs fill the tri-mode 8SFF box behind an MR416i-o in the OCP slot, which leaves the PCIe risers free.

  • 2 × Xeon Gold 6542Y — 24 cores @ 2.9 GHz, 250 W each
  • 16 × 64 GB DDR5-5600 RDIMM — 1 TB (runs at 5200 MT/s)
  • 8 × 3.84 TB SAS SSD in the tri-mode 8SFF box
  • MR416i-o 8 GB cache controller in Slot 14 (OCP 1)
  • Broadcom BCM57414 2 × 10/25GbE OCP3 in Slot 15
  • 2 × 1000 W Flex Slot Titanium
  • Windows Server 2025 Datacenter

At 250 W these processors need the Performance heat sink, the second processor brings the Second CPU Fan Kit, and two OCP adapters need the OCP2 Enablement Kit — all added on the quote.

Open this build in the configurator →
Backup & tape

LFF disk-to-tape backup server

The LFF chassis plus an internal LTO drive keeps disk and tape copies in one tower. Tape takes Box 1, so two 4LFF boxes remain — eight 24 TB SAS drives, 192 TB raw. A 12-core Silver 4410Y is ample for backup software, the tertiary riser powers the tape drive without a second processor, and a 16-port MR216i-o leaves ports for the drives and the tape.

  • 1 × Xeon Silver 4410Y — 12 cores @ 2 GHz, 150 W
  • 8 × 32 GB DDR5-4800 RDIMM — 256 GB (4000 MT/s with this processor)
  • 4 × 24 TB 3.5-inch SAS HDD in one 4LFF box — 96 TB raw as linked
  • MR216i-o 16-port controller in Slot 14 (OCP 1)
  • Broadcom BCM57416 2 × 10GbE BASE-T OCP3
  • 2 × 800 W Flex Slot Platinum
  • Windows Server 2025 Standard

Add the second 4LFF box, the internal LTO drive, the tertiary riser (P49693-B21), the LTO support kit (P62309-B21) and the Second CPU Fan Kit the riser requires on the quote. With tape in Box 1 the server holds eight LFF drives, not twelve.

Open this build in the configurator →
GPU inference

Four-L4 GPU tower

Four 24 GB L4 cards add 96 GB of GPU memory at 72 W each, and HPE supports them at 30 °C inlet whatever the drive-box count. Two 32-core Gold 6448Y processors and 512 GB of DDR5 meet HPE’s advice that system memory be twice the GPU memory. Local NVMe holds models and data.

  • 2 × Xeon Gold 6448Y — 32 cores @ 2.1 GHz, 225 W each
  • 4 × NVIDIA L4 24 GB
  • 16 × 32 GB DDR5-4800 RDIMM — 512 GB
  • 4 × 3.84 TB NVMe U.3 in the tri-mode 8SFF box
  • MR408i-o 4 GB cache controller in Slot 14
  • Intel E810-XXVDA2 2 × 10/25GbE OCP3
  • 2 × 1600 W Flex Slot Platinum (200–240 V AC)
  • Red Hat Enterprise Linux 9

Four x16 cards need both 2x16 risers (primary FIO and secondary), and the L4 requires the External GPU Fan Kit, which covers those risers’ rear connectors. Both system fan kits are mandatory with any GPU. The Gold 6448Y appears only in HPE’s standard-features processor table, with no separate option kit, so confirm it on the quote.

Open this build in the configurator →
All-flash database

Twelve-drive E3.S database tower

Twelve 7.68 TB E3.S NVMe drives in the 12EDSFF cage give 92.16 TB raw, mirrored by VROC NVMe without a controller. Two 16-core Gold 6526Y processors satisfy the cage’s two-processor rule while keeping the core count modest, and 1 TB of DDR5 sits behind them.

  • 2 × Xeon Gold 6526Y — 16 cores @ 2.8 GHz, 195 W each
  • 12 × 7.68 TB E3.S NVMe — 92.16 TB raw
  • 16 × 64 GB DDR5-5600 RDIMM — 1 TB (runs at 5200 MT/s)
  • Intel VROC NVMe (RAID licence on the quote)
  • NS204i-u NVMe boot device
  • Intel E810-CQDA2 2 × 100GbE OCP3
  • 2 × 1600 W Flex Slot Platinum (200–240 V AC)
  • SUSE Linux Enterprise Server 15

The 12EDSFF cage is factory-fitted, direct-attach only (cable kit P48400-B21) and rules out every other drive cage. It holds the inlet to 25 °C, and its bundled rear fan covers the primary riser, so no external cables can reach that riser.

Open this build in the configurator →
10 — Refurbished alternatives

When a refurbished ProLiant makes more sense

Our refurbished HPE configurator spans Gen10 and Gen10 Plus. Its only tower is the ML350 Gen10; if the new server would be racked anyway, two DL380 generations cover the same ground.

Gen10 · re-certified

HPE ProLiant ML350 Gen10

  • Tower, rack-convertible · 2 × Xeon Scalable
  • 24 DIMM slots · up to 3 TB DDR4
  • Up to 24 × SFF or 12 × LFF
  • iLO 5

A rack-convertible tower with the same 24 SFF or 12 LFF front drive counts, on DDR4 and iLO 5, for an office that doesn’t need current-generation processors.

Configure a refurbished ML350 Gen10 →
Gen10 Plus · re-certified

HPE ProLiant DL380 Gen10 Plus

  • 2U rack · 2 × Ice Lake Xeon
  • 32 DIMM slots · up to 8 TB DDR4-3200
  • SFF, LFF or NVMe · PCIe 4.0
  • OCP 3.0 · iLO 5

When the server is going into a rack anyway, the DDR4 DL380 Gen10 Plus offers 32 memory slots against the ML350 Gen10’s 24.

Configure a refurbished DL380 Gen10 Plus →
Gen10 · re-certified

HPE ProLiant DL380 Gen10

  • 2U rack · 2 × Xeon Scalable
  • 24 DIMM slots · up to 3 TB DDR4
  • 24 × SFF or 12 × LFF
  • GPU-capable · iLO 5

A 2U with the ML350 Gen10’s drive counts and memory ceiling, for a comms rack rather than an office floor.

Configure a refurbished DL380 Gen10 →
Refurbished HPE ProLiant serversRefurbished ProLiant configuratorNew vs refurbished cost calculator
11 — Full specifications

HPE ProLiant ML350 Gen11 specifications

Chassis & cooling

Form factor4U tower · 5U racked with the Tower-to-Rack kit (P47394-B21)
CTO chassisLFF (P48404-B21, one 4LFF box) · SFF (P48405-B21, one 8SFF box)
Dimensions (H × W × D)Tower 46.2 × 17.4 × 71.2 cm · rack system 17.4 × 44.5 × 64.8 cm
WeightSFF 24.73–37.18 kg · LFF 27.42–43.05 kg
Fans3 standard · performance models typically ship with 8

Processor

SocketsOne or two (same model)
Family4th and 5th Gen Intel Xeon Scalable · no 4th-to-5th Gen field upgrade
Cores per processor8 to 64
TDP125 W to 350 W
Listed SKUs57 (43 with HPE option kits)
InterconnectUPI 16 GT/s · 80 PCIe 5.0 lanes per processor

Memory

Slots32 DDR5 RDIMM · 16 per processor · 8 channels × 2 DIMMs
Kits16–128 GB · DDR5-4800 (4th Gen) or DDR5-5600 (5th Gen)
Maximum8.0 TB printed (32 × 256 GB at 4400 MT/s) · 4 TB with the listed 128 GB kits
ProtectionAdvanced ECC

Storage

Front24 SFF (3 × 8SFF tri-mode) · 12 LFF (3 × 4LFF) · 8 SFF x4 NVMe · 12 E3.S
Maximum raw312 TB LFF · 368.64 TB SFF
ControllersVROC SATA / NVMe · MR216i, MR408i, MR416i (-o and -p) · SR932i-p · E208e-p
BootNS204i-u Gen11 · NS204i-u v2 960 GB, standard or SED
Tape & opticalOne internal LTO-8 or LTO-9 in Box 1 · DVD-ROM or DVD-RW

Expansion & networking

PCIe slotsUp to 10 × PCIe 5.0: primary 4 × x8 or 2 × x16 · secondary 4 × x8 or 2 × x16 · tertiary 2 × x8
OCPSlot 14 (OCP 1) · Slot 15 (OCP 2, default for the NIC)
LOMNone · CTO default BCM5719 4 × 1 Gb OCP3

Accelerators

Models (max)L40 (4) · L40S (2) · A16 (4) · L4 (4) · RTX A1000 (8)
RulesBoth fan kits · one model per server · two x16 cards per 2x16 riser

Power

SuppliesUp to 2 × Flex Slot hot-plug, no mixing
AC500 W & 800 W Platinum · 1000 W Titanium · 1600 W Platinum (200–240 V) · 1800–2200 W Titanium (200–240 V)
DC1600 W −48 V DC

Ports & video

FrontUSB 3.2 Gen1 · DisplayPort · iLO service port
Rear2 × USB 3.2 Gen1 · VGA · 1 Gb iLO · optional serial
InternalUSB 3.2 Gen1 · USB 2.0
Video1920 × 1200 at 60 Hz · 16 MB

Environment & warranty

Operating temperature10–35 °C · extended 5–45 °C for approved configurations
Acoustics (LwA,m)3.9–4.1 B idle · 4.1–4.2 B operating
Warranty3 years parts, labour and on-site, next business day
12 — FAQ

ML350 Gen11 questions, answered from the documentation

What is the maximum memory of the HPE ProLiant ML350 Gen11?

HPE prints 8.0 TB: all 32 slots with 256 GB RDIMMs at 4400 MT/s, two per channel. However, the memory options it lists stop at 128 GB, which works out at 4 TB across the same 32 slots. A single-processor server can populate only 16 slots, so half of either figure.

Which processors does the ML350 Gen11 take?

One or two 4th or 5th Gen Intel Xeon Scalable processors of the same model. HPE’s tables list 57 of them, 8-core to 64-core, rated between 125 W and 350 W. A 4th Gen server can’t be field-upgraded to 5th Gen parts, and seven SKUs are for single-socket builds only.

How many drives does the ML350 Gen11 hold?

Up to 24 SFF drives in three tri-mode 8SFF boxes, or 12 LFF drives in three 4LFF boxes; the LFF chassis can mix the two box types. The alternative factory cages hold 8 x4 NVMe SFF or 12 E3.S drives, and each has to be the only cage in the server.

Can the ML350 Gen11 be mounted in a rack?

Yes. The Tower-to-Rack Conversion Kit (P47394-B21) adds a 1U section, 69.2 cm deep or 83.5 cm with the cable-management arm, so the racked server takes 5U. The kit isn’t installed at the factory and ships as a separate item.

Which GPUs does the ML350 Gen11 support?

Five NVIDIA models, one type per server: up to eight RTX A1000, four L40, A16 or L4, or two L40S. Each needs both extra fan kits. Supported inlet temperature drops with more drive boxes — for the L40, from 27 °C with one box to 23 °C with three, or 30 °C in HPE’s limited two-GPU configuration.

How loud is the ML350 Gen11?

HPE’s declaration for five standard configurations gives sound power of 3.9 to 4.1 B at idle and 4.1 to 4.2 B operating, or 25 to 26 dBA at the bystander position. Extra options can raise those figures; HPE notes the fans may run faster with GPUs and with the 12EDSFF cage.

Which power supplies can the ML350 Gen11 use?

A maximum of two Flex Slot hot-plug units, matched: the Platinum 500 W, 800 W or 1600 W, the Titanium 1000 W or 1800–2200 W, or the −48 V DC 1600 W. HPE restricts the 500 W unit to builds with one 125 W processor, and the two largest AC units run only on 200–240 V.

How big and heavy is the ML350 Gen11?

As a tower it measures 46.2 cm high, 17.4 cm wide and 71.2 cm deep; racked, the system itself is 17.4 × 44.5 × 64.8 cm. HPE quotes 24.73 kg for a minimal SFF build and up to 43.05 kg for a fully loaded LFF build.

What changed from the ML350 Gen11 to the ML350 Gen12?

According to the two QuickSpecs, Gen12 moves to Xeon 6 P-core processors — up to 86 cores, 88 PCIe lanes and 24 GT/s UPI, against 64 cores, 80 lanes and 16 GT/s — plus iLO 7 and DDR5-6400, with 8.0 TB running at 5200 MT/s rather than 4400. It swaps the LFF and SFF chassis for one chassis with no default cage, and lets the 12-bay E3.S cage share the front with SFF or LFF boxes.

Is the HPE ProLiant ML350 Gen11 end of life?

Version 47 of HPE’s QuickSpecs (8 September 2026) still offers both CTO chassis and gives no end-of-sale or end-of-support date; the retirements it records are individual option SKUs. Standard cover runs three years for parts, labour and on-site visits, next business day, and HPE’s dates will appear in our end-of-life checker when announced.

Sources & verification

Where these figures come from

Specifications are extracted from HPE’s published documents and independently re-checked line by line. Configurations are quote-based; availability and exact options are confirmed at quotation. Last reviewed 2026-09-11.

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