Technical data sheet · ProLiant Compute Gen12 · 2U dual-socket

HPE ProLiant Compute DL380 Gen12Specifications, configurations & comparisons

The ProLiant Compute DL380 Gen12 is HPE’s 2U two-socket server for Intel Xeon 6, taking either E-core processors of up to 144 cores or P-core processors of up to 86. This data sheet maps the QuickSpecs envelope — DDR5-6400, five chassis types, eight PCIe 5.0 slots and double-wide GPUs capped at 450 W — and the cooling kits and drive trade-offs that come with it.

2U Rack1 or 2 socketsXeon 6 E-coreXeon 6 P-coreHPE iLO 7

144cores per CPU288 per server · Xeon 6 E-core

8.0TBDDR5 maximum32 DIMM slots

36drive bays13 drive-cage kits

8GPUs7 accelerators listed

2,200Wlargest PSU5 supply options

34processor SKUs2 families

Configure a DL380 Gen12 →Get a UK quote Refurbished alternatives ↓

Every figure checked against the HPE ProLiant DL380 Gen12 QuickSpecs (Version 19 - 08-Sep-2026)

Image: Hewlett Packard Enterprise

Form factor: 2U Rack · 2 sockets
Processors: Xeon 6 E-core · Xeon 6 P-core
Memory: 32 × DDR5 RDIMM · up to 8.0 TB
Drive bays: Up to 36 · 13 drive-cage kits
Expansion: 8 × PCIe · 2 × OCP 3.0
GPUs: Up to 8 · 7 listed
Boot: NS204i · 6 boot options
Management: HPE iLO 7

01 — Overview

The DL380 Gen12 at a glance

Our read of HPE’s documentation: where the DL380 Gen12 is strong, and the limits worth knowing before you spec one.

Strengths

Two Xeon 6 core types in one chassis: seven E-core parts of 64 to 144 cores for dense throughput, and 27 P-core parts of 8 to 86 cores for per-core speed.
DDR5 runs at 6400 MT/s on a single DIMM per channel and still at 6000 MT/s on two, so a fully populated 8 TB server keeps a high memory speed.
All eight rear slots are PCIe 5.0, a second OCP 3.0 slot can be cabled in at x8 or x16, and SFF or EDSFF chassis can move OCP NICs to the front.
Seven accelerators are listed, from eight single-wide L4 or RTX A1000 cards up to two H200 NVL or three RTX PRO 6000 running at a 450 W cap.
LFF capacity reaches 20 drives — 12 front, a 4LFF midplane and 4 rear — and the EDSFF chassis holds 36 E3.S NVMe drives.

Watch-outs

GPUs and rear drive cages cannot be combined, and GPU models cannot be mixed.
The H200 NVL, RTX PRO 6000 and RTX PRO 6000D need the Cooling Upgrade Enablement Kit and the 1U High Performance heat sink; with the kit, processors are held to 270 W at 30 °C or 350 W at 27 °C, and those three GPUs to 27 °C ambient.
The 4LFF midplane cage accepts processors of 225 W or less only, and cannot be combined with direct liquid cooling.
The 36-drive EDSFF direct-attach bundle gives up every riser slot and runs both OCP slots at x8.
HPE’s two processor listings disagree on the 6714P: 165 W in the option kit, 195 W in the feature table.

Processors34 SKUs

Cores / CPU8–144

DIMM slots32

Drive-cage kits13

Max bays36

GPUsup to 8

PSU options5 · to 2,200 W

02 — Processors

34 supported processors, mapped

HPE lists 34 Xeon 6 processors for the DL380 Gen12 — seven 6700E-series E-core parts and 27 P-core parts across its Performance General Purpose, Mainline and Socket Scalable groups — from 8 to 144 cores and 135 W to 350 W. The landscape below places every SKU by core count and TDP, and the explorer sorts and filters them.

Processor landscape — cores × TDP

34 SKUs · 2 families

Xeon 6 E-core 7Xeon 6 P-core 27Bubble size = L3 cache · hover a bubble for the full SKU

Processor explorer

filter · sort · compare

Sort

Processor	Cores / threads	Base	L3 cache	TDP	W / core	Memory
Intel Xeon 6780E	144	2.2 GHz	108 MB	330 W	2.3	DDR5-6400
Intel Xeon 6766E	144	1.9 GHz	108 MB	250 W	1.7	DDR5-6400
Intel Xeon 6756E	128	1.8 GHz	96 MB	225 W	1.8	DDR5-6400
Intel Xeon 6746E	112	2 GHz	96 MB	250 W	2.2	DDR5-5600
Intel Xeon 6731E	96	2.2 GHz	96 MB	250 W	2.6	DDR5-5600
Intel Xeon 6740E	96	2.4 GHz	96 MB	250 W	2.6	DDR5-6400
Intel Xeon 6787P	86	2 GHz	336 MB	350 W	4.1	DDR5-6400
Intel Xeon 6788P	86	2 GHz	336 MB	350 W	4.1	DDR5-6400
Intel Xeon 6710E	64	2.4 GHz	96 MB	205 W	3.2	DDR5-5600
Intel Xeon 6762P	64	2.9 GHz	320 MB	350 W	5.5	DDR5-6400
Intel Xeon 6767P	64	2.4 GHz	336 MB	350 W	5.5	DDR5-6400
Intel Xeon 6760P	64	2.2 GHz	320 MB	330 W	5.2	DDR5-6400
Intel Xeon 6768P	64	2.4 GHz	336 MB	330 W	5.2	DDR5-6400
Intel Xeon 6747P	48	2.7 GHz	288 MB	330 W	6.9	DDR5-6400
Intel Xeon 6748P	48	2.5 GHz	192 MB	300 W	6.3	DDR5-6400
Intel Xeon 6740P	48	2.1 GHz	288 MB	270 W	5.6	DDR5-6400
Intel Xeon 6736P	36	2 GHz	144 MB	205 W	5.7	DDR5-6400
Intel Xeon 6732P	32	3.8 GHz	144 MB	350 W	10.9	DDR5-6400
Intel Xeon 6745P	32	3.1 GHz	336 MB	300 W	9.4	DDR5-6400
Intel Xeon 6737P	32	2.9 GHz	144 MB	270 W	8.4	DDR5-6400
Intel Xeon 6738P	32	2.9 GHz	144 MB	270 W	8.4	DDR5-6400
Intel Xeon 6730P	32	2.5 GHz	288 MB	250 W	7.8	DDR5-6400
Intel Xeon 6530P	32	2.3 GHz	144 MB	225 W	7.0	DDR5-6400
Intel Xeon 6527P	24	3 GHz	144 MB	255 W	10.6	DDR5-6400
Intel Xeon 6520P	24	2.4 GHz	144 MB	210 W	8.8	DDR5-6400
Intel Xeon 6728P	24	2.7 GHz	144 MB	210 W	8.8	DDR5-6400
Intel Xeon 6725P	16	3.7 GHz	192 MB	235 W	14.7	DDR5-6400
Intel Xeon 6724P	16	3.6 GHz	72 MB	210 W	13.1	DDR5-6400
Intel Xeon 6517P	16	3.2 GHz	72 MB	190 W	11.9	DDR5-6400
Intel Xeon 6515P	16	2.3 GHz	72 MB	150 W	9.4	DDR5-6400
Intel Xeon 6505P	12	2.2 GHz	48 MB	150 W	12.5	DDR5-6400
Intel Xeon 6714P	8	4 GHz	48 MB	165 W	20.6	DDR5-6400
Intel Xeon 6507P	8	3.5 GHz	48 MB	150 W	18.8	DDR5-6400
Intel Xeon 6503P	8	2.8 GHz	48 MB	135 W	16.9	DDR5-6400

The two processors must be the same model.
The Standard heat sink covers processors up to 185 W; the Max Performance heat sink is for two-processor builds only, heat-sink types cannot be mixed, and HPE’s configurator picks the heat sink from the processor and thermal needs.
The 6731E is shown with no UPI links (UPI = 0) in HPE’s processor table.
The 8-core, 2.8 GHz, 135 W Xeon 6503P was added in version 19 of the QuickSpecs.
Direct liquid cooling uses cold-plate modules in an NS204i-u or a PCIe position, cannot be mixed with air-cooled heat sinks, and iLO 7 raises leak alerts and can shut the server down.

03 — Memory

32 DIMM slots, 16 per processor

Thirty-two DDR5 RDIMM slots — sixteen per processor across eight channels, two DIMMs per channel. Xeon 6 tops out at 6400 MT/s when each channel holds a single DIMM; a second DIMM per channel brings that to 6000 MT/s, which is the speed of the 8 TB maximum (32 × 256 GB).

Capacity with every slot filled

by DIMM size

Operating speed

per HPE memory tables

Processor	1 DIMM / channel	2 DIMMs / channel
Intel Xeon 6 (E-core and P-core)	6400 MT/s*	6000 MT/s

* Each processor’s own DDR5 rating caps the speed: HPE lists the 6710E, 6731E and 6746E at 5600 MT/s.
The 16 GB DIMM is supported with one DIMM per channel only.
Every kit is a DDR5-6400 RDIMM, from 16 GB to 128 GB, plus a 256 GB 3DS RDIMM; MRDIMMs are not in the option list.
Advanced ECC, ADDDC (enabled by default, with a possible performance cost under some workloads) and memory mirroring are available.
The -B21 kits are for separate orders; factory-integrated builds use the matching -F21 SKUs.

04 — Storage

13 drive-cage kits, up to 36 bays

Five configure-to-order chassis set the front: SFF (up to 24 bays, or media-bay and multipurpose-cage options), 24SFF, 8LFF, 12LFF and EDSFF. Rear cages replace riser positions, and LFF chassis can add a 4LFF midplane. The layouts are HPE’s complete maximums; the kit chart lists each cage.

Headline layouts

front panel view

Front panel

Rear module

The EDSFF chassis with three 12-bay E3.S cages and an optional 2SFF rear cage. With HPE’s 36EDSFF x4 direct-attach bundle, all three risers are given up and both OCP slots drop to x8.

SAS/SATANVMeSAS/SATA + NVMe

Controllers & boot

HPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device — Boot. NVMe hot-plug boot device; locations: rear (Rear Mount Enablement Kit P74755-B21, includes cable; externally accessible with P77928-B21), internal, or front multipurpose cage (P74759-B21; front only on SFF/EDSFF CTO Server).
HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device — Boot. NVMe hot-plug boot device; locations: rear (Rear Mount Enablement Kit P74755-B21, includes cable; externally accessible with P77928-B21), internal, or front multipurpose cage (P74759-B21; front only on SFF/EDSFF CTO Server).
HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device — Boot. NVMe hot-plug boot device; locations: rear (Rear Mount Enablement Kit P74755-B21, includes cable; externally accessible with P77928-B21), internal, or front multipurpose cage (P74759-B21; front only on SFF/EDSFF CTO Server).
Intel Virtual RAID on CPU Premium FIO Software for HPE — Software RAID. Intel VROC for HPE ProLiant; RAID levels not printed in this document.
Intel Virtual RAID on CPU RAID 1 FIO Software for HPE — Software RAID. Intel VROC RAID 1 (per name).
HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Plug-in Storage Controller — RAID, 8GB cache. PCIe plug-in. Requires Smart Storage Battery/capacitor (P01366-B21 96W battery, P02377-B21 hybrid capacitor, or P65038-B21 16W hybrid capacitor; max 1 per server).
HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller — RAID, 8GB cache. OCP (OROC). Requires Smart Storage Battery/capacitor (P01366-B21 96W battery, P02377-B21 hybrid capacitor, or P65038-B21 16W hybrid capacitor; max 1 per server).
HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Plug-in Storage Controller — RAID. PCIe plug-in; no cache.
HPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device (P78279-B21) — boot
HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device (P81160-B21) — boot
HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device (P81162-B21) — boot
HPE ProLiant Compute DL380 Gen12 NS204i-u Rear Mount Enablement Kit (P74755-B21) — boot

All 14 controllers and 6 boot options

HPE MR216i-o Gen11 x16 Lanes without Cache OCP SPDM Storage Controller — RAID. OCP (OROC); no cache.
HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller — RAID, 4GB cache. OCP (OROC). Requires Smart Storage Battery/capacitor (P01366-B21 96W battery, P02377-B21 hybrid capacitor, or P65038-B21 16W hybrid capacitor; max 1 per server).
HPE MR408i-p Gen11 x8 Lanes 4GB Cache PCI SPDM Plug-in Storage Controller — RAID, 4GB cache. PCIe plug-in. Requires Smart Storage Battery/capacitor (P01366-B21 96W battery, P02377-B21 hybrid capacitor, or P65038-B21 16W hybrid capacitor; max 1 per server).
HPE MR932i-p x32 Lanes PCIe Gen5 SPDM Plug-in Storage Controller — RAID. PCIe Gen5 plug-in; supports SAS and NVMe SSDs only (no HDDs). Cache size not printed; battery backup integrated (Smart Storage Battery not required). Up to 16 EDSFF drives via x2 EDSFF Controller Attach FIO Kit P92742-B21.
Gen12 x8 Lanes without Cache SAS 12G PCIe Plug-in Controller. Name printed truncated exactly as shown (no brand/model prefix) in Step 3f Storage Controller; RAID vs HBA and internal vs external not stated in this document.
HPE DL385 Gen10 Plus 12Gb NVMe 2-port Adapter — Retimer. Listed under Step 3f Storage Controller, but the FIO bundles use it as the 'Gen4 retimer card' for x4 direct-attach NVMe (e.g. P78064-B21, P77937-B21, P77940-B21, P77943-B21). Not a RAID/HBA controller.
HPE ProLiant Compute DL380 Gen12 NS204i-u Rear Access FIO Enablement Kit (P77928-B21) — boot
HPE ProLiant Compute Gen12 NS204i-u Front Enablement Kit (P74759-B21) — boot

The 8SFF x1 tri-mode cage runs SAS, SATA or NVMe from an MR tri-mode controller; the x4 cage connects NVMe either straight to the processors or through a tri-mode controller, at x4 or, with reduced bandwidth, x2.
The MR932i-p (PCIe 5.0, 32 lanes) handles SAS and NVMe SSDs but no hard drives, has battery backup built in, and with the x2 EDSFF Controller Attach kit runs 16 EDSFF drives.
The MR408i and MR416i require a Smart Storage battery or hybrid capacitor; the MR932i-p does not.
Boot is the NS204i-u v2 (480 GB, 960 GB or 960 GB SED) at the rear, internally, or — on SFF and EDSFF chassis — in the front multipurpose cage.
LFF chassis offer two rear schemes: up to 4 LFF or 2 SFF, or 2 LFF and/or 2 SFF.
A Universal Media Bay on the SFF chassis adds a front DisplayPort, two USB 2.0 ports and an optical drive; the 8LFF takes an optical drive through its own enablement kit.

Every documented drive-cage kit

13 with drive bays

2.5-inch3.5-inchEDSFF (E1.S / E3.S)

05 — Accelerators & I/O

GPUs, PCIe and networking

GPUs install in the rear risers, each double-wide card taking two slots. HPE supports the H200 NVL, RTX PRO 6000 and RTX PRO 6000D only with their power capped at 450 W, and the H200 NVL’s cap needs iLO Advanced with Advanced Power Management enabled. Up to 8 × single-wide L4 or RTX A1000, 5 × RTX PRO 4500, 3 × double-wide L40S, RTX PRO 6000 or 6000D, or 2 × H200 NVL.

NVIDIA H200 NVL 141GB PCIe Accelerator for HPE

double-wide

141GB · up to 2

NVIDIA RTX PRO 6000 Blackwell Server Edition 96GB PCIe Accelerator for HPE

double-wide

96GB · up to 3

NVIDIA RTX PRO 6000D 84GB PCIe Accelerator for HPE

double-wide

84GB · up to 3

NVIDIA L40S 48GB PCIe Accelerator

double-wide

48GB · up to 3

NVIDIA RTX PRO 4500 Blackwell Server Edition 32GB PCIe Accelerator for HPE

single-wide

32GB · up to 5

NVIDIA L4 24GB PCIe Accelerator for HPE

single-wide

24GB · up to 8

NVIDIA RTX A1000 8GB PCIe Accelerator for HPE

single-wide

8GB · up to 8

I/O topology

2 sockets

Eight rear PCIe 5.0 slots sit on three risers, with up to six wired x16 and up to two x8. Slots 1 to 3 are fed by the first processor, while risers two and three stay unusable on a one-processor server. Eight DDR5 channels hang off each processor.

Network adapters HPE lists

39 options

Adapter	Ports	Form
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE	4 × 1GbE	PCIe
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE	2 × 10GbE	PCIe
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE	2 × 10GbE	PCIe
AMD Solarflare X4522-PLUS 10/25GbE 2-port SFP56 Adapter for HPE	2 × 10/25GbE	PCIe
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE	4 × 10/25GbE	PCIe
NVIDIA Ethernet 10/25Gb 2-port SFP28 NVMe-oF Crypto Adapter for HPE	2 × 10/25GbE	PCIe
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Intel E810-XXVDA4 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE	4 × 10/25GbE	PCIe
Xilinx X2522-25G-PLUS Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Mellanox MCX631102AS-ADAT Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Broadcom BCM57608 Ethernet 100Gb 2-port QSFP112 Adapter for HPE	2 × 100GbE	PCIe
Mellanox MCX623106AS-CDAT Ethernet 100Gb 2-port QSFP56 Adapter for HPE	2 × 100GbE	PCIe
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 Adapter for HPE	2 × 100GbE	PCIe
NVIDIA Ethernet 100Gb 2-port NVMe-oF Offload Adapter for HPE	2 × 100GbE	PCIe
HPE InfiniBand NDR/Ethernet 400Gb 1-port OSFP PCIe5 x16 MCX75310AAS-NEAT Generic Adapter	1 × InfiniBand NDR / 400GbE	PCIe
HPE InfiniBand NDR200/Ethernet 200Gb 1-port OSFP PCIe5 x16 MCX75310AAS-HEAT Generic Adapter	1 × InfiniBand NDR200 / 200GbE	PCIe
HPE InfiniBand NDR200/Ethernet 200GbE 2-port QSFP112 PCIe5 x16 MCX755106AC-HEAT Adapter	2 × InfiniBand NDR200 / 200GbE	PCIe
HPE InfiniBand XDR400/Ethernet 400GbE 2-port QSFP112 PCIe6 x16 HHHL CX8 Crypto Adapter	2 × InfiniBand XDR400 / 400GbE	PCIe
HPE InfiniBand XDR/Ethernet 2x400GbE 1-port OSFP PCIe6 x16 HHHL CX8 Crypto Adapter	1 × InfiniBand XDR / 2x400GbE	PCIe
HPE Data Processing Unit InfiniBand NDR200/Ethernet 200Gb 2-port QSFP112 FHHL B3220 Adapter	2 × InfiniBand NDR200 / 200GbE	PCIe
HPE Data Processing Unit InfiniBand NDR/Ethernet 400Gb 1-port QSFP112 HHHL B3140H Adapter	1 × InfiniBand NDR / 400GbE	PCIe
HPE SN1620E 32Gb 2p FC SecureHBA	2 × 32Gb Fibre Channel	PCIe
HPE SN1720E 64Gb 2p FC SecureHBA	2 × 64Gb Fibre Channel	PCIe
HPE SN1610Q 32Gb 1-port Fibre Channel Host Bus Adapter	1 × 32Gb Fibre Channel	PCIe
HPE SN1610Q 32Gb 2-port Fibre Channel Host Bus Adapter	2 × 32Gb Fibre Channel	PCIe
HPE SN1700Q 64Gb 1-port Fibre Channel Host Bus Adapter	1 × 64Gb Fibre Channel	PCIe
HPE SN1700Q 64Gb 2-port Fibre Channel Host Bus Adapter	2 × 64Gb Fibre Channel	PCIe
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE	4 × 1GbE	OCP 3.0
Intel E610-IT4 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE	4 × 1GbE	OCP 3.0
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T OCP3 Adapter for HPE	2 × 10GbE	OCP 3.0
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter for HPE	2 × 10GbE	OCP 3.0
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 OCP3 Adapter for HPE	4 × 10/25GbE	OCP 3.0
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Intel E810-XXVDA4 Ethernet 10/25Gb 4-port SFP28 OCP3 Adapter for HPE	4 × 10/25GbE	OCP 3.0
Mellanox MCX631432AS-ADAI Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Broadcom BCM57608 Ethernet 100Gb 2-port QSFP112 OCP3 Adapter for HPE	2 × 100GbE	OCP 3.0
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 OCP3 Adapter for HPE	2 × 100GbE	OCP 3.0

The 3 × x16 secondary riser and the tertiary riser cannot be fitted together.
Slot 1 on the 3 × x16 primary riser, and slot 4 on the 3 × x16 secondary, stay disabled until two P76471-B21 cable kits and a trigger SKU are ordered; some direct-attach bundles run that slot at x8.
OCP A is embedded at x8 and reaches x16 with the P72201-B21 cable kit; OCP B is cabled from either processor. With two processors both OCP slots can run at x16.
Front and rear OCP slots cannot be active at the same time, and OCP A carries the shared-NIC (NC-SI) function.
There is no embedded network controller — an OCP 3.0 or stand-up NIC is part of every order.
NVIDIA BlueField B3220 and B3140H DPUs were added in version 19; the B3220 also needs the Cooling Upgrade Enablement Kit.

06 — Power & cooling

5 power supplies, 800–2,200 W

Power supplies are HPE Flex Slot hot-plug units, five models in all. AC input comes through the 800 W or 1600 W Platinum and the 1000 W or 1800–2200 W Titanium; DC sites use the 1600 W −48 V model, ordered with HPE’s lug kit or DC power cable kit. A server never mixes two different models.

AC−48 V DC

The 1600 W Platinum supply is high-line only (200–240 VAC).
Energy Star 4.0 builds cannot use the 800 W or 1600 W Platinum supplies.
In HPE’s acoustic declarations the entry SFF build (one 6507P, one 800 W supply, four standard fans) measured 4.2 B idle, and the dense LFF build 6.0 B operating.
The Cooling Upgrade Enablement Kit adds six fans and air baffles, either to run double-wide GPUs at higher ambient temperatures or to carry more drives at the same temperature.

07 — Management, security & OS

Run it, secure it, choose the OS

Management

HPE iLO 7 (iLO 7 ASIC) with Intelligent Provisioning as standard
Three-year HPE Compute Ops Management subscription added by default
iLO Advanced and HPE OneView Advanced optional
OpenBMC capable through the iLO 7 transfer-of-ownership process
iLO RESTful API (Redfish) · iLO mobile app · Active Health System
iLO 7 leak detection that can shut down liquid-cooled builds
Dedicated 1 Gb rear iLO port · front USB-C iLO service port

Security

Silicon Root of Trust
TPM 2.0 embedded; can be disabled in the BIOS
iLO-managed and UEFI-managed encryption, with self-encrypting drive support
One-button secure erase to NIST SP 800-88
FIPS 140-3, NIST SP 800-53 and SP 800-171 compliance
System maintenance switch, USB security, bezel lock and chassis intrusion switch
HPE Trusted Supply Chain (P36394-B21) optional

Operating systems

OS and hypervisor certification is published in HPE’s Servers Support & Certification Matrices, not the QuickSpecs
UEFI 2.10, Class 3 · TPM 2.0 and NVMe boot in UEFI boot mode
Redfish Secure Boot key management and retirement of the old VMware Secure Boot key

08 — Compare

How the DL380 Gen12 compares with its family

The DL380 Gen12 is the general-purpose 2U of HPE’s Xeon 6 rack line. The DL360 Gen12 puts Xeon 6 into 1U, the DL380a Gen12 is a 4U GPU server, the DL340 Gen12 is a single-socket 2U, the DL580 Gen12 scales to four sockets, and the DL380 Gen11 is the Xeon Scalable model before it. Each bar comes from that model’s verified spec file.

This modelSiblings and successorEach value from that model’s own verified spec file · bars scale per column

DL380 Gen11 data sheet DL360 Gen12 data sheet DL380a Gen12 data sheet DL340 Gen12 data sheet DL580 Gen12 data sheet Dell R760 vs DL380 Gen12 R760 vs DL380 Gen12 vs Lenovo SR650 V3 Dell R760xa vs DL380 Gen12 Dell PowerEdge R770 data sheet Lenovo ThinkSystem SR650 V4 data sheet

09 — Use cases

Four builds that suit the DL380 Gen12

Four DL380 Gen12 builds, all made of options the configurator permits on this server, which open pre-filled when you click through. We check the cooling kit, riser and cage rules HPE attaches to each one before we quote.

AI inference

Two RTX PRO 6000 inference node

Two 96 GB RTX PRO 6000 Blackwell cards give 192 GB of GPU memory at HPE’s 450 W cap, and the 32-core, 270 W 6737P stays within the processor limits of the Cooling Upgrade kit those cards require. A terabyte of DDR5-6400 and front NVMe keep models and data local, with a 200 Gb uplink.

2 × Xeon 6737P — 32 cores @ 2.9 GHz, 270 W each
2 × NVIDIA RTX PRO 6000 Blackwell Server Edition 96 GB
16 × 64 GB DDR5-6400 RDIMM — 1 TB
4 × 7.68 TB NVMe U.3 in one 8SFF cage
NS204i-u v2 NVMe boot device
HPE InfiniBand NDR200 / 200GbE 2-port QSFP112
2 × 1800–2200 W Flex Slot Titanium
Red Hat Enterprise Linux 9 (3-year)

HPE supports these cards only at a 450 W power cap and 27 °C maximum ambient, with the Cooling Upgrade Enablement Kit, the 1U High Performance heat sink and the double-wide GPU power cable kit. Fitting GPUs rules out rear drive cages.

Open this build in the configurator →

Cloud-native

288-core E-core container host

Two 144-core Xeon 6766E processors put 288 E-cores in 2U at 250 W each — a fit for container platforms and scale-out web tiers where thread count matters more than per-core speed. Sixteen 96 GB RDIMMs give 1.5 TB at one DIMM per channel.

2 × Xeon 6766E — 144 cores @ 1.9 GHz, 250 W each
16 × 96 GB DDR5-6400 RDIMM — 1.5 TB, one per channel
8 × 3.84 TB NVMe U.3 in one 8SFF cage
NS204i-u v2 NVMe boot device
Intel E810-XXVDA4 4 × 10/25GbE OCP 3.0
2 × 1600 W Flex Slot Platinum (200–240 VAC)
Red Hat Enterprise Linux 9

Open this build in the configurator →

Backup & archive

20-bay LFF backup target

The 12LFF chassis is the DL380 Gen12 route to 20 large drives: 12 front, 4 in the midplane cage and 4 at the rear, a layout HPE’s maximum-storage table rates at 360 TB with 18 TB SAS hard drives. Sixteen-core 6515P processors at 150 W stay well under the midplane’s 225 W limit.

2 × Xeon 6515P — 16 cores @ 2.3 GHz, 150 W each
10 × 24 TB 3.5-inch SAS HDD — 240 TB raw as linked
One 4LFF front box, the 4LFF midplane cage and a 2LFF rear cage
MR416i-p tri-mode controller, 8 GB cache
16 × 32 GB DDR5-6400 RDIMM — 512 GB
NS204i-u v2 NVMe boot device
Broadcom BCM57414 2 × 10/25GbE OCP 3.0
Windows Server 2025 Standard

The link opens with one front LFF box and one rear cage; add the rest in the configurator for the 20-drive layout. The midplane cage cannot be combined with direct liquid cooling, and rear drives rule out GPUs.

Open this build in the configurator →

Analytics

All-flash EDSFF analytics node

Twelve 30.72 TB E3.S drives in one EDSFF cage give 368.64 TB raw, and the chassis takes two more cages for 36. Two 64-core 6767P processors and 2 TB of DDR5-6400 suit in-memory and scan-heavy analytics, with a 100GbE OCP uplink.

2 × Xeon 6767P — 64 cores @ 2.4 GHz, 350 W each
12 × 30.72 TB E3.S NVMe — 368.64 TB raw
16 × 128 GB DDR5-6400 RDIMM — 2 TB
NS204i-u v2 NVMe boot device
Broadcom BCM57608 2 × 100GbE QSFP112 OCP 3.0
2 × 1800–2200 W Flex Slot Titanium
SUSE Linux Enterprise Server 15

At the full 36 E3.S, HPE’s x4 direct-attach bundle gives up every riser slot and holds both OCP slots to x8.

Open this build in the configurator →

10 — Refurbished alternatives

When a refurbished ProLiant makes more sense

For projects that need neither Xeon 6, DDR5 nor iLO 7, our refurbished ProLiant configurator has earlier two-socket servers from the DDR4 generation.

Gen10 Plus · re-certified

HPE ProLiant DL380 Gen10 Plus

2U · 2 × Ice Lake Xeon
32 DIMM slots · up to 8 TB DDR4-3200
24 × SFF or 12 × LFF · NVMe options
PCIe 4.0 · OCP 3.0 · iLO 5

The last DDR4 generation of the DL380, for virtualisation and database refreshes on a smaller budget.

Configure a refurbished DL380 Gen10 Plus →

Gen10 Plus · re-certified

HPE ProLiant DL385 Gen10 Plus

2U · 2 × AMD EPYC 7002/7003
Up to 128 cores · 32 DIMM slots
Up to 8 TB DDR4-3200 · PCIe 4.0
24 × SFF or 12 × LFF · iLO 5

An AMD EPYC 2U with up to 128 cores for VM consolidation, if Intel Xeon 6 is not a requirement.

Configure a refurbished DL385 Gen10 Plus →

Gen10 Plus · re-certified

HPE ProLiant DL360 Gen10 Plus

1U · 2 × 3rd Gen Xeon (Ice Lake)
32 DIMM slots · up to 8 TB DDR4-3200
PCIe 4.0 · up to 10 NVMe
iLO 5

Sites short of rack space rather than drive bays, where a 1U Ice Lake server with up to ten NVMe drives will do.

Configure a refurbished DL360 Gen10 Plus →

Refurbished HPE ProLiant servers Refurbished ProLiant configurator New vs refurbished cost calculator

11 — Full specifications

HPE ProLiant Compute DL380 Gen12 specifications

Chassis & cooling

Form factor	2U rack
Chassis (CTO)	SFF, 24SFF, 12LFF, 8LFF, EDSFF — no embedded LOM
Dimensions (H × W × D)	8.75 × 44.80 × 72.70 cm (SFF/EDSFF) · 73.25 cm deep (LFF), excluding PSUs
Weight	SFF 18–33 kg · LFF 23–37 kg
Fans	4 standard (SFF, 8LFF) · 6 standard (12LFF, EDSFF) · 6 high-performance (24SFF)
Liquid cooling	Optional DLC cold-plate modules · iLO 7 leak detection

Processor

Sockets	One or two (same model)
Family	Intel Xeon 6 — 6700E E-core and 6500P/6700P P-core
Cores per processor	8 to 144
TDP	135 W to 350 W
Listed SKUs	34 (7 E-core, 27 P-core)

Memory

Slots	32 DDR5 RDIMM · 16 per processor · 8 channels × 2 DIMMs
Kits	16, 32, 64, 96, 128 GB RDIMM · 256 GB 3DS RDIMM — all DDR5-6400
Speed	6400 MT/s (1 DPC) · 6000 MT/s (2 DPC), capped by the processor
Maximum	8.0 TB (32 × 256 GB at 6000 MT/s)
Protection	Advanced ECC · ADDDC · mirroring

Storage

Front	Up to 24 × SFF U.3 tri-mode, 12 × LFF, 36 × E3.S, or 12 × E3.S + 16 × SFF
Midplane	Optional 4LFF (8LFF/12LFF chassis, processors ≤ 225 W)
Rear	Up to 6 × SFF (SFF chassis) · 4 × LFF or 2 × SFF (LFF chassis) · 2 × SFF (EDSFF)
Maximum	30 SFF · 20 LFF · 36 E3.S
Controllers	Intel VROC · MR216i-p/-o, MR408i-p/-o, MR416i-p/-o · MR932i-p (SAS and NVMe SSD only)
Boot	NS204i-u v2 480 GB, 960 GB or 960 GB SED — rear, internal or front

Expansion & networking

PCIe slots	Up to 8 × PCIe 5.0 (up to 6 × x16, up to 2 × x8)
OCP	Rear OCP A (x8, x16 with cable) and OCP B (cabled) · or front OCP on SFF/EDSFF
LOM	None
DPU	NVIDIA BlueField B3220 or B3140H

Accelerators

Double-wide	H200 NVL (max 2), RTX PRO 6000 / 6000D (max 3) at a 450 W cap · L40S (max 3)
Single-wide	RTX PRO 4500 (max 5) · L4 and RTX A1000 (max 8)
Rules	No mixing · no rear drives with a GPU

Power

Supplies	Flex Slot hot-plug
AC	800 W Platinum · 1000 W Titanium · 1600 W Platinum (200–240 VAC) · 1800–2200 W Titanium
DC	1600 W −48 V DC

Ports & video

Front	USB 3.2 Gen1 · USB-C iLO service port · optional DisplayPort and 2 × USB 2.0 (UMB)
Rear	2 × USB 3.2 Gen1 · VGA · 1 Gb iLO port · optional serial
Internal	2 × USB 3.0
Video	1920 × 1200 at 60 Hz · 16 MB

Environment & warranty

Operating temperature	10–35 °C at sea level · 5–45 °C extended for approved configurations
Maximum altitude	3,050 m
Warranty	3 years parts, labour and on-site, next business day

12 — FAQ

DL380 Gen12 questions, answered from the documentation

What is the maximum memory of the HPE ProLiant DL380 Gen12?

It holds 8.0 TB: all 32 slots filled with 256 GB 3DS RDIMMs, running at 6000 MT/s with two DIMMs per channel. With one DIMM per channel Xeon 6 runs DDR5 at 6400 MT/s, subject to each processor’s own rating, and the 16 GB DIMM is limited to one per channel.

Which processors does the DL380 Gen12 support?

Up to two Intel Xeon 6 processors of the same model. HPE lists seven E-core parts of 64 to 144 cores and 27 P-core parts of 8 to 86 cores, from 135 W to 350 W; the 8-core 6503P arrived in the latest revision.

How many drives does the DL380 Gen12 hold?

Up to 36 E3.S NVMe drives in the EDSFF chassis, 30 SFF drives (24 front, 6 rear) or 20 LFF drives (12 front, 4 midplane, 4 rear). The EDSFF chassis can instead mix 12 E3.S with up to 16 SFF drives at the front.

How many GPUs can the DL380 Gen12 take?

Up to eight single-wide L4 or RTX A1000, five RTX PRO 4500, three double-wide L40S, RTX PRO 6000 or RTX PRO 6000D, or two H200 NVL. The H200 NVL and both RTX PRO 6000 models run at a 450 W cap with the Cooling Upgrade kit, models cannot be mixed, and no GPU can share the server with rear drives.

How many PCIe slots does the DL380 Gen12 have?

Eight rear PCIe 5.0 slots — up to six at x16 and two at x8 — on primary, secondary and tertiary risers, plus two OCP 3.0 slots. A second processor is needed for risers two and three, and choosing the 3 × x16 secondary riser rules out the tertiary one.

Which power supplies are available for the DL380 Gen12?

There are five Flex Slot hot-plug choices — 1000 W and 1800–2200 W Titanium, 800 W and 1600 W Platinum, and a 1600 W −48 V DC unit — and two different models cannot be mixed. The 1600 W Platinum is high-line only, and neither Platinum unit is allowed in an Energy Star 4.0 configuration.

How big and heavy is the DL380 Gen12?

It is 8.75 cm high, 44.80 cm wide and 72.70 cm deep in SFF and EDSFF form, or 73.25 cm deep with LFF bays, measured without the power supplies. HPE gives 18 to 33 kg for SFF builds and 23 to 37 kg for LFF builds.

Should I choose E-core or P-core Xeon 6 for the DL380 Gen12?

The seven 6700E E-core parts offer 64 to 144 cores at 205 W to 330 W with base clocks of 1.8 to 2.4 GHz, which suits container, web and scale-out work where thread count matters. The 27 P-core parts have 8 to 86 cores and base clocks up to 4.0 GHz, on the 8-core 6714P. HPE rates the E-cores at 5600 or 6400 MT/s memory and every P-core part at 6400 MT/s.

What changed from the DL380 Gen11 to the DL380 Gen12?

By the two QuickSpecs, the Gen12 replaces 4th and 5th Gen Xeon Scalable with Xeon 6, iLO 6 with iLO 7 and the Gen11’s DDR5-4800 and DDR5-5600 kits with DDR5-6400, and runs tertiary slot 8 at PCIe 5.0 where the Gen11’s default riser has it at PCIe 4.0 x16. It adds 450 W-capped double-wide GPUs and gives 20 LFF drives as its limit, where the Gen11 overview says 16, but lists no SFF mid-tray, so its SFF maximum is 30 against the Gen11’s 36 SAS drives.

Is the HPE ProLiant DL380 Gen12 end of life?

No. HPE’s QuickSpecs (version 19, 8 September 2026) lists current configure-to-order models and states no end-of-life or end-of-service date — the SKUs it marks obsolete are options such as drives and adapters. The server carries a three-year parts, labour and on-site warranty; should HPE announce end-of-sale or end-of-support dates, our end-of-life checker will list them.

Sources & verification

Where these figures come from

HPE ProLiant DL380 Gen12 QuickSpecs (Version 19 - 08-Sep-2026) — Overview and chassis types, processor tables and option kits, heat sinks and DLC, memory, PCIe riser and OCP tables, maximum internal storage, drive cages and FIO bundles, storage controllers, GPU options and cooling kit, power supplies, technical specifications, security and warranty.
HPE ProLiant DL380 Gen11 QuickSpecs (Version 47 - 08-Sep-2026) — Gen11 facts in the generation FAQ.

Specifications are extracted from HPE’s published documents and independently re-checked line by line. Configurations are quote-based; availability and exact options are confirmed at quotation. Last reviewed 2026-09-11.

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The DL380 Gen12 at a glance

Strengths

Watch-outs

34 supported processors, mapped

Processor landscape — cores × TDP

Processor explorer

32 DIMM slots, 16 per processor

Capacity with every slot filled

Operating speed

13 drive-cage kits, up to 36 bays

Headline layouts

Controllers & boot

Every documented drive-cage kit

GPUs, PCIe and networking

NVIDIA H200 NVL 141GB PCIe Accelerator for HPE

NVIDIA RTX PRO 6000 Blackwell Server Edition 96GB PCIe Accelerator for HPE

NVIDIA RTX PRO 6000D 84GB PCIe Accelerator for HPE

NVIDIA L40S 48GB PCIe Accelerator

NVIDIA RTX PRO 4500 Blackwell Server Edition 32GB PCIe Accelerator for HPE

NVIDIA L4 24GB PCIe Accelerator for HPE

NVIDIA RTX A1000 8GB PCIe Accelerator for HPE

I/O topology

Network adapters HPE lists

5 power supplies, 800–2,200 W

Run it, secure it, choose the OS

Management

Security

Operating systems

How the DL380 Gen12 compares with its family

Four builds that suit the DL380 Gen12

Two RTX PRO 6000 inference node

288-core E-core container host

20-bay LFF backup target

All-flash EDSFF analytics node

When a refurbished ProLiant makes more sense

HPE ProLiant DL380 Gen10 Plus

HPE ProLiant DL385 Gen10 Plus

HPE ProLiant DL360 Gen10 Plus

HPE ProLiant Compute DL380 Gen12 specifications

Chassis & cooling

Processor

Memory

Storage

Expansion & networking

Accelerators

Power

Ports & video

Environment & warranty

DL380 Gen12 questions, answered from the documentation

Where these figures come from

Buy & configure

Guides & family

Plan the deployment

Support & lifecycle

Get a quote for the HPE ProLiant Compute DL380 Gen12

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