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HPE ProLiant DL380 Gen12 2U 2-socket rack server front view
HPE ProLiant DL380-Gen12
144 Cores
Per socket (Xeon 6)
8 TB
Max DDR5 at 6400 MT/s
8+2 PCIe
Gen5 slots + OCP 3.0
iLO7
Security Enclave
Authorised Reseller
📦 Free UK Delivery
🔒 Full Warranty
📞 24/7 Support
Key Specifications
Form Factor2U rack-mountable, 2-socket (2P)
Processors SupportedIntel Xeon 6 E-Core (up to 144c, 6780E 330W) and P-Core (up to 86c, 6787P 350W)
Memory TypeHPE DDR5 Smart Memory RDIMM
Memory Slots32 DIMM slots (16 per processor, 8 channels, 2 DIMMs per channel)
Max Memory8 TB (32 × 256 GB) at 6400 MT/s (1DPC) / 5200 MT/s (2DPC)
Memory ProtectionAdvanced ECC, ADDDC, mirroring
Storage Options8SFF (to 24SFF), 8LFF, 12LFF, 12EDSFF (to 36EDSFF E3.S); optional rear SFF/LFF bays
PCIe ExpansionUp to 8 × PCIe Gen5 x16 (primary + secondary + tertiary risers) + 2 OCP 3.0 (rear) + optional 2 front OCP
+6 more specs below ↓
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Download Official Datasheet
PDF · Official manufacturer document
HPE ProLiantSKU: DL380-Gen12

HPE ProLiant Compute DL380 Gen12 2U 2-Socket Rack Server

Next-Gen 2U Rack Server — Intel Xeon 6 up to 144 Cores, 8 PCIe Gen5 Slots, iLO 7

The HPE ProLiant Compute DL380 Gen12 is the most capable 2U server in HPE's latest generation lineup. Powered by Intel Xeon 6 processors with up to 144 cores per socket, DDR5 memory at 6400 MT/s, up to 8 PCIe Gen5 expansion slots plus 2 OCP 3.0, and HPE iLO 7 with Security Enclave, it is designed for demanding enterprise workloads, AI/ML, and cloud-native environments.

  • Intel Xeon 6 — up to 144 cores per socket (E-Core & P-Core)
  • DDR5 up to 8 TB at 6400 MT/s (1DPC) — 32 DIMM slots
  • Up to 8 PCIe Gen5 slots + 2 OCP 3.0 (primary, secondary, tertiary risers)
  • Storage: 8SFF/24SFF, 8LFF/12LFF, 12/36 EDSFF E3.S configurations
  • HPE iLO 7 with Security Enclave & quantum-resistance
  • GPU performance kit for improved thermals (post-launch)
  • Air, closed-loop liquid, and direct liquid cooling options
  • AI-driven HPE Compute Ops Management (3-yr included)

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Key Features

Everything you need in one device

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Intel Xeon 6 — Up to 144 Cores

Supports Intel Xeon 6 E-Core processors up to 144 cores (Xeon 6766E, 6780E) and P-Core processors up to 86 cores (Xeon 6787P, 350W). DDR5 memory up to 6400 MT/s at 1DPC enables maximum throughput for data-intensive workloads.

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DDR5 6400 MT/s — Up to 8 TB

32 DIMM slots (16 per processor, 8 channels per processor) support DDR5 RDIMM up to 256 GB per DIMM. Memory speed: 6400 MT/s at 1DPC, 5200 MT/s at 2DPC. Advanced ECC, ADDDC, and mirroring for data integrity.

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Up to 8 PCIe Gen5 Slots

Three riser options (primary, secondary, tertiary) provide up to 8 PCIe Gen5 slots in x16 connectors, plus 2 rear OCP 3.0 slots and optional front OCP NIC slots (post-launch). Enables dense GPU and HPC configurations.

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Versatile Storage Configurations

8SFF server upgradeable to 24SFF front. Also available in 8LFF, 12LFF, and 12/36 EDSFF E3.S configurations. Optional rear drive bays in all chassis types. Supports NS204i-u front/rear boot device.

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HPE iLO 7 & Quantum Security

iLO 7 Security Enclave provides hardware-based tamper-resistant key storage. Supports NIST and CNSA 2.0 quantum-resistance requirements. First industry-standard server to pursue FIPS 140-3 Level 3 certification (HPE, Jan 2025).

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Direct Liquid Cooling

DL380 Gen12 supports direct liquid cooling (DLC) alongside closed-loop liquid cooling (CLLC) — allowing high-TDP Intel Xeon 6 configurations while minimising acoustic and thermal impact on the data centre environment.

About the HPE ProLiant DL380 Gen12

The HPE ProLiant Compute DL380 Gen12 raises the bar for 2U enterprise rack servers. Built on Intel Xeon 6 — the first major Intel server processor architecture to unify Efficient Core and Performance Core variants in a single generation — the DL380 Gen12 delivers up to 144 cores per socket while supporting the same DDR5 6400 MT/s memory interface across all processor variants.

Expansion capability is dramatically improved over the Gen11: three riser card positions (primary, secondary, tertiary) provide up to 8 PCIe Gen5 slots in full-height x16 connectors, with additional OCP 3.0 slots at the rear. Post-launch support adds front OCP NIC slots via the multipurpose cage. This level of I/O density makes the DL380 Gen12 suitable for GPU-accelerated AI workloads without requiring a dedicated GPU chassis.

Storage flexibility is the widest in any 2U platform from HPE. The 8SFF CTO server can be upgraded incrementally to 24SFF using additional drive cages. Alternatively, 8LFF, 12LFF, or 12EDSFF (expandable to 36 EDSFF) configurations are available. NS204i-u boot devices can be installed at the front, rear, or internal positions depending on chassis configuration.

HPE iLO 7 delivers significant security improvements over iLO 6: the new Security Enclave is a hardware-based vault within the iLO ASIC protecting server encryption keys from physical tampering. The DL380 Gen12 is designed to satisfy FIPS 140-3 Level 3 requirements and supports quantum-resistance through CNSA 2.0 secure firmware signing — critical for long-term compliance in regulated industries.

Technical Specifications

Form Factor2U rack-mountable, 2-socket (2P)
Processors SupportedIntel Xeon 6 E-Core (up to 144c, 6780E 330W) and P-Core (up to 86c, 6787P 350W)
Memory TypeHPE DDR5 Smart Memory RDIMM
Memory Slots32 DIMM slots (16 per processor, 8 channels, 2 DIMMs per channel)
Max Memory8 TB (32 × 256 GB) at 6400 MT/s (1DPC) / 5200 MT/s (2DPC)
Memory ProtectionAdvanced ECC, ADDDC, mirroring
Storage Options8SFF (to 24SFF), 8LFF, 12LFF, 12EDSFF (to 36EDSFF E3.S); optional rear SFF/LFF bays
PCIe ExpansionUp to 8 × PCIe Gen5 x16 (primary + secondary + tertiary risers) + 2 OCP 3.0 (rear) + optional 2 front OCP
RAID ControllersHPE MR416i-p (8 GB cache), MR408i-o (4 GB cache); Intel VROC
ManagementHPE iLO 7 (Security Enclave, Redfish API), HPE Compute Ops Management
CoolingAir (standard/performance), closed-loop liquid cooling (CLLC), direct liquid cooling (DLC)
NetworkOCP 3.0 or PCIe NIC; optional 2 front OCP (post-launch); up to 200GbE
Operating SystemsWindows Server, VMware ESXi, RHEL, SLES, Ubuntu, Oracle Linux
Warranty3/3/3 (3-year parts, 3-year labour, 3-year on-site)
📄 Download Datasheet (PDF)
Use Cases

Ideal for a wide range of deployments

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AI & ML Training

Up to 8 PCIe Gen5 GPU slots, Intel Xeon 6 E-Core for throughput-optimised training pipelines, and 8 TB DDR5 memory make the DL380 Gen12 a strong in-server AI platform.

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Virtualisation & Private Cloud

Industry-standard 2U form factor with 144-core density and 8 TB DDR5 memory delivers exceptional VM consolidation for VMware vSphere, Nutanix, and private cloud deployments.

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Enterprise Databases

SAP HANA, Oracle Database, and Microsoft SQL Server benefit from DDR5 6400 MT/s bandwidth, high-core-count P-Core processors, and extensive SSD storage configurations.

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Cloud-Native & Kubernetes

Designed for HPE GreenLake hybrid cloud — deploy as Kubernetes worker nodes or OpenStack compute nodes with unified management across on-premises and cloud estates.

FAQ

Frequently Asked Questions

Q. What processors does the HPE ProLiant DL380 Gen12 support?

The DL380 Gen12 supports Intel Xeon 6 in both E-Core and P-Core variants. E-Core: up to 144 cores (6780E, 330W) for throughput; P-Core: up to 86 cores (6787P, 350W) for frequency-sensitive workloads. Memory speed is up to 6400 MT/s at 1DPC.

Q. How many PCIe Gen5 slots does the DL380 Gen12 have?

Up to 8 PCIe Gen5 slots via three riser card positions (primary: 3 slots, secondary: 3 slots, tertiary: 2 slots), plus 2 rear OCP 3.0 slots and optional front OCP NIC slots. Note: secondary and tertiary risers require a second processor.

Q. Can I buy the HPE ProLiant DL380 Gen12 from Servnet?

Yes — Servnet is an authorised HPE reseller in the UK. Contact sales@servnetuk.com for a Gen12 configuration quote including processor, memory, storage, RAID, and GPU options.

Why Servnet

Why buy from Servnet?

Trusted UK IT reseller since 2003 — supplying businesses of all sizes with genuine, competitively priced technology.

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Authorised UK Reseller

Servnet is an authorised IT reseller with direct access to leading product lines at competitive pricing.

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Expert Pre-Sales Advice

Our engineers will help you select the right product and advise on compatibility with your existing infrastructure.

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Fast UK Delivery

Most products ship from UK stock. Express delivery available for urgent deployments.

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Genuine, Warranted Kit

All products are genuine, brand-new, with full manufacturer warranty and RMA support.

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Configuration Services

We can pre-configure your hardware before shipping — reducing on-site deployment time and cost.

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24/7 Support

Post-sale support from our certified engineers. We're here if anything goes wrong.

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