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Head-to-head · every figure from the vendor documents

Dell R7725 vs HPE DL380 Gen12

A specification-by-specification comparison of the Dell PowerEdge R7725 and the HPE ProLiant Compute DL380 Gen12, built from Dell’s and HPE’s own documents. 3 headline measures favour the R7725, 3 favour the DL380 Gen12, and they share no processors.

Bottom line. R7725 leads on storage density. DL380 Gen12 leads on databases and in-memory work, AI and acceleration, network throughput. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.

Dell PowerEdge R7725 front view in the 40 × EDSFF E3.S Gen5 NVMe layout, with left and right control panels at either end
Dell PowerEdge
R7725
2U Rack2 sockets24 DIMMiDRAC10
Configure the R7725 →Full data sheet
VS
HPE ProLiant Compute DL380 Gen12 2U server, front view: 24 SFF bays in three 8-bay boxes, USB-C iLO port, USB port and health LEDs
HPE ProLiant
DL380 Gen12
2U Rack2 sockets32 DIMMHPE iLO 7
Configure the DL380 Gen12 →Full data sheet
01 — Scoreboard

The measures that decide it

Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.

2
Processor sockets
2
384Higher
Cores, fully populated
Largest listed processor × its socket count
288
6 TB
Memory ceiling
As each document states it
Higher8 TB
40Higher
Drive bays
36
Up to 6
Accelerators
HigherUp to 8
3,200 WHigher
Largest power supply
2,200 W
2U Rack
Rack height
2U Rack
200 GbE class
Fastest network option
Higher400 GbE class
02 — Verdict

Which one, and why

Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.

Choose the R7725 if…

  • Cores, fully populated: 384 against 288 on the DL380 Gen12
  • Drive bays: 40 against 36 on the DL380 Gen12
  • Largest power supply: 3,200 W against 2,200 W on the DL380 Gen12
  • Up to 192 Zen5 cores per socket, with even the 500 W parts listed for air cooling — the 4th Gen EPYC R7625 in Dell’s comparison table stopped at 128 cores.

Choose the DL380 Gen12 if…

  • Memory ceiling: 8 TB against 6 TB on the R7725
  • Accelerators: Up to 8 against Up to 6 on the R7725
  • Fastest network option: 400 GbE class against 200 GbE class on the R7725
  • Two Xeon 6 core types in one chassis: seven E-core parts of 64 to 144 cores for dense throughput, and 27 P-core parts of 8 to 86 cores for per-core speed.
03 — By workload

Where each one pulls ahead

Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.

VirtualisationR7725: 384 cores with 6 TB. DL380 Gen12: 288 cores with 8 TB.Line ball
Databases & in-memoryMemory ceiling 6 TB against 8 TB, across 24 and 32 DIMM slots.DL380 Gen12
Storage density40 bays in 2U against 36 in 2U.R7725
AI & acceleration6 accelerators against 8 in the vendor documents.DL380 Gen12
Network throughputFastest card listed: 200 GbE class against 400 GbE class.DL380 Gen12
04 — Specifications

Side by side, differences first

Everything both documents state, grouped. The default view hides rows where the two machines are identical.

Processors

Every processor each vendor lists for the model, from its own document.

SpecificationR7725DL380 Gen12
Processors listed2034
Most cores per processor192144
Highest processor TDP500 W350 W
Processor familiesAMD EPYC 9005Xeon 6 E-core · Xeon 6 P-core
Single-processor optionNoYes

Memory

SpecificationR7725DL380 Gen12
DIMM slots2432
Slots per processor1216

Storage

Bay counts are the maximum each document states, including rear and mid-chassis positions.

SpecificationR7725DL380 Gen12
Maximum bays4036
Documented layouts913
Bay sizes2.5-inch · 3.5-inch · E3.S2.5-inch · E3.S · 3.5-inch
Boot devicesBOSS-N1 DC-MHS (RAID 0/1, 2 x M.2 NVMe 480 GB or 960 GB read-intensive) · Internal USBHPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device + 3 more
Storage controllers514

Accelerators & I/O

SpecificationR7725DL380 Gen12
Accelerators supportedUp to 6Up to 8
Double-wide cards listed64
Network cards listed1639

Power & platform

SpecificationR7725DL380 Gen12
Power-supply options115
Output range800–3,200 W800–2,200 W
Input typesAC · 277 VAC / HVDCAC · −48 V DC
ManagementiDRAC10HPE iLO 7
Chassis depthVendors measure depth differently — see each data sheet801.51 mm without bezel / 802.4 mm with bezelSFF/EDSFF CTO: 72.70 cm (28.62 in)
05 — The data

Processors, memory, bays and power

The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.

R7725: processors by cores and TDP

Dell PowerEdge R7725 processors081624324048566472808896104112120128136144152160168176184192100 W150 W200 W250 W300 W350 W400 W450 W500 WCores per processorAMD EPYC 9965 — 192 cores / 384 threads · 500 W · 2.25 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9845 — 160 cores / 320 threads · 390 W · 2.1 GHz base · 320 MB cache · DDR5-6400AMD EPYC 9825 — 144 cores / 288 threads · 390 W · 2.2 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9755 — 128 cores / 256 threads · 500 W · 2.7 GHz base · 512 MB cache · DDR5-6400AMD EPYC 9745 — 128 cores / 256 threads · 400 W · 2.4 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9655 — 96 cores / 192 threads · 400 W · 2.6 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9575F — 64 cores / 128 threads · 400 W · 3.3 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9555 — 64 cores / 128 threads · 360 W · 3.2 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9535 — 64 cores / 128 threads · 300 W · 2.4 GHz base · 256 MB cache · DDR5-6000AMD EPYC 9475F — 48 cores / 96 threads · 400 W · 3.65 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9455 — 48 cores / 96 threads · 300 W · 3.15 GHz base · 256 MB cache · DDR5-6000AMD EPYC 9375F — 32 cores / 64 threads · 320 W · 3.8 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9355 — 32 cores / 64 threads · 280 W · 3.55 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9335 — 32 cores / 64 threads · 210 W · 3 GHz base · 128 MB cache · DDR5-6400AMD EPYC 9275F — 24 cores / 48 threads · 320 W · 4.1 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9255 — 24 cores / 48 threads · 200 W · 3.2 GHz base · 128 MB cache · DDR5-6400AMD EPYC 9175F — 16 cores / 32 threads · 320 W · 4.2 GHz base · 512 MB cache · DDR5-6400AMD EPYC 9135 — 16 cores / 32 threads · 200 W · 3.65 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9115 — 16 cores / 32 threads · 125 W · 2.6 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9015 — 8 cores / 16 threads · 125 W · 3.6 GHz base · 64 MB cache · DDR5-6400EPYC 9965192 cores — the top SKUEPYC 98452.4 W/core — most efficient
AMD EPYC 9005 20Bubble size = L3 cache · hover a bubble for the full SKU

DL380 Gen12: processors by cores and TDP

HPE ProLiant Compute DL380 Gen12 processors081624324048566472808896104112120128136144100 W150 W200 W250 W300 W350 WCores per processorIntel Xeon 6780E — 144 cores · 330 W · 2.2 GHz base · 108 MB cache · DDR5-6400Intel Xeon 6766E — 144 cores · 250 W · 1.9 GHz base · 108 MB cache · DDR5-6400Intel Xeon 6756E — 128 cores · 225 W · 1.8 GHz base · 96 MB cache · DDR5-6400Intel Xeon 6746E — 112 cores · 250 W · 2 GHz base · 96 MB cache · DDR5-5600Intel Xeon 6731E — 96 cores · 250 W · 2.2 GHz base · 96 MB cache · DDR5-5600Intel Xeon 6740E — 96 cores · 250 W · 2.4 GHz base · 96 MB cache · DDR5-6400Intel Xeon 6710E — 64 cores · 205 W · 2.4 GHz base · 96 MB cache · DDR5-5600Intel Xeon 6787P — 86 cores · 350 W · 2 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6788P — 86 cores · 350 W · 2 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6762P — 64 cores · 350 W · 2.9 GHz base · 320 MB cache · DDR5-6400Intel Xeon 6767P — 64 cores · 350 W · 2.4 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6760P — 64 cores · 330 W · 2.2 GHz base · 320 MB cache · DDR5-6400Intel Xeon 6768P — 64 cores · 330 W · 2.4 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6747P — 48 cores · 330 W · 2.7 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6748P — 48 cores · 300 W · 2.5 GHz base · 192 MB cache · DDR5-6400Intel Xeon 6740P — 48 cores · 270 W · 2.1 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6736P — 36 cores · 205 W · 2 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6732P — 32 cores · 350 W · 3.8 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6745P — 32 cores · 300 W · 3.1 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6737P — 32 cores · 270 W · 2.9 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6738P — 32 cores · 270 W · 2.9 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6730P — 32 cores · 250 W · 2.5 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6530P — 32 cores · 225 W · 2.3 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6527P — 24 cores · 255 W · 3 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6520P — 24 cores · 210 W · 2.4 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6728P — 24 cores · 210 W · 2.7 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6725P — 16 cores · 235 W · 3.7 GHz base · 192 MB cache · DDR5-6400Intel Xeon 6724P — 16 cores · 210 W · 3.6 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6517P — 16 cores · 190 W · 3.2 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6515P — 16 cores · 150 W · 2.3 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6505P — 12 cores · 150 W · 2.2 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6714P — 8 cores · 165 W · 4 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6507P — 8 cores · 150 W · 3.5 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6503P — 8 cores · 135 W · 2.8 GHz base · 48 MB cache · DDR5-64006780E144 cores — the top SKU6766E1.7 W/core — most efficient
Xeon 6 E-core 7Xeon 6 P-core 27Bubble size = L3 cache · hover a bubble for the full SKU

R7725: memory with every slot filled

16 GB384 GB32 GB768 GB64 GB1.5 TB96 GB2.3 TB128 GB3 TB256 GB6 TB24 slots · 12 per processor · each tick = one DIMM

DL380 Gen12: memory with every slot filled

16 GB512 GB32 GB1 TB64 GB2 TB96 GB3 TB128 GB4 TB256 GB8 TB32 slots · 16 per processor · each tick = one DIMM

R7725: drive bays

Front panel

40 × EDSFF NVMe at the front — 40 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

DL380 Gen12: drive bays

Front panel

12 × EDSFF NVMe at the front — 12 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

R7725: power supplies

0500100015002000250030003500800 W Platinum — 100-240 VAC or 240 VDC; 60 mm800Platinum800 W Titanium — 100-240 VAC or 240 VDC; 60 mm800Titanium1100 W Platinum — 100-240 VAC (derated to 1050 W at 100-120 VAC) or 240 VDC; 60 mm1100Platinum1100 W Titanium — 100-240 VAC (derated to 1050 W at 100-120 VAC) or 240 VDC; 60 mm1100Titanium1400 W N/A (DC) — -48 to -60 VDC Telco; DC power cable1400DC1500 W Titanium — 100-240 VAC (derated to 1050 W at 100-120 VAC) or 240 VDC; 60 mm; C131500Titanium1500 W Titanium — 277 VAC or 336 VDC HVDC; 60 mm; APP/Saf-D-Grid1500Titanium1800 W Titanium — 200-240 VAC or 240 VDC mixed mode; 60 mm; C161800Titanium2400 W Titanium — 100-240 VAC or 240 VDC mixed mode; 73.5 mm; C192400Titanium3200 W Titanium — 200-240 VAC or 240 VDC mixed mode; 73.5 mm; C193200Titanium3200 W Titanium — 277 VAC or 336 VDC HVDC; 73.5 mm; APP/Saf-D-Grid3200TitaniumWatts · dashed line = output at 100–120 V low line
AC277 VAC / HVDC

DL380 Gen12: power supplies

05001000150020002500800 W Platinum — HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit. Input voltage not printed. Not compatible with Energy Star 4.0 compliance (doc: 'Platinum Power Supply 800W & 1600W are not compatible').800Platinum1000 W Titanium — HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit. Named in the ErP Lot 9 section as 96% efficient. Input voltage not printed.1000Titanium1600 W null — HPE 1600W Flex Slot -48VDC Hot Plug Power Supply Kit; no efficiency rating printed. Requires HPE 1600W -48VDC Power Cable Lug Kit (P36877-B21) OR the 1600W DC PSU Power Cable Kit.1600DC1600 W Platinum — HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit. '1600W Power supplies only support high line voltage (200 VAC to 240 VAC).' Not compatible with Energy Star 4.0 compliance.1600Platinum2200 W Titanium — Printed as 'HPE 1800W-2200W Flex Slot Titanium Hot Plug Power Supply Kit' (watts recorded as upper figure; per-voltage ratings not printed). Named in the ErP Lot 9 section as 96% efficient.2200TitaniumWatts · dashed line = output at 100–120 V low line
AC−48 V DC
07 — Questions

R7725 vs DL380 Gen12, answered

Is the R7725 or the DL380 Gen12 the faster server?

Neither document publishes benchmark results, so this page compares what they do state. The R7725 lists 20 processors up to 192 cores at 500 W; the DL380 Gen12 lists 34 up to 144 cores at 350 W. Fully populated that is 384 cores against 288.

Which holds more memory?

The R7725 has 24 DIMM slots and a stated ceiling of 6 TB. The DL380 Gen12 has 32 and 8.0 TB.

Which takes more drives?

R7725: 40 bays across 9 documented layouts. DL380 Gen12: 36 across 13. Counts include rear and mid-chassis positions where the vendor documents them.

Can either take GPUs?

R7725: up to 6 accelerators, 6 double-wide cards listed. DL380 Gen12: up to 8, 4 double-wide listed.

Do they share any processors?

No. The two documents list different processors, so a like-for-like processor build is not possible across these two.

Where these figures come from. R7725: Dell PowerEdge R7725 Technical Guide (June 2026) (Dell document). DL380 Gen12: HPE ProLiant DL380 Gen12 QuickSpecs (Version 19 - 08-Sep-2026) (HPE document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.

Other comparisons in this class

R7625 vs DL380 Gen12Dell vs HPER770 vs DL380 Gen12Dell vs HPER7725 vs DL385 Gen11Dell vs HPER7725 vs SR665 V3Dell vs LenovoR7725 vs SR650 V3Dell vs LenovoDL380 Gen12 vs SR650a V4HPE vs LenovoDL380 Gen12 vs SR665 V3HPE vs LenovoR7625 vs R7725Generation upgrade

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