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Head-to-head · every figure from the vendor documents

HPE DL380 Gen10 vs HPE DL380 Gen12

A specification-by-specification comparison of the HPE ProLiant DL380 Gen10 and the HPE ProLiant Compute DL380 Gen12, built from HPE’s own documents. None of the headline measures favour the DL380 Gen10; 4 favour the DL380 Gen12, and they share no processors.

Bottom line. DL380 Gen12 leads on virtualisation, databases and in-memory work, storage density, network throughput. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.

DL380 Gen10 front: eight 2.5-inch SAS bays, two premium bays, an optical drive and the media-bay ports, with the model badge at the right
HPE ProLiant
DL380 Gen10
2U Rack2 sockets24 DIMMHPE iLO 5
Configure the DL380 Gen10 →Full data sheet
VS
HPE ProLiant Compute DL380 Gen12 2U server, front view: 24 SFF bays in three 8-bay boxes, USB-C iLO port, USB port and health LEDs
HPE ProLiant
DL380 Gen12
2U Rack2 sockets32 DIMMHPE iLO 7
Configure the DL380 Gen12 →Full data sheet
01 — Scoreboard

The measures that decide it

Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.

DL380 Gen102
Processor sockets
DL380 Gen122
DL380 Gen1056
Cores, fully populated
Largest listed processor × its socket count
DL380 Gen12288Higher
DL380 Gen103 TB
Memory ceiling
As each document states it
DL380 Gen128 TBHigher
DL380 Gen1024
Drive bays
DL380 Gen1236Higher
DL380 Gen10Up to 8
Accelerators
DL380 Gen12Up to 8
DL380 Gen102,200 W
Largest power supply
DL380 Gen122,200 W
DL380 Gen102U Rack
Rack height
DL380 Gen122U Rack
DL380 Gen10100 GbE class
Fastest network option
DL380 Gen12400 GbE classHigher
02 — Verdict

Which one, and why

Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.

Choose the DL380 Gen10 if…

  • Expansion is the whole argument for this chassis. Three riser positions carry as many as eight PCIe 3.0 slots, and the pair of x16/x16/x16 GPU riser kits each take three single-width accelerators — six across two processors. The 1U DL360 Gen10, built from the identical processor table, reaches three slots in total.

Choose the DL380 Gen12 if…

  • Cores, fully populated: 288 against 56 on the DL380 Gen10
  • Memory ceiling: 8 TB against 3 TB on the DL380 Gen10
  • Drive bays: 36 against 24 on the DL380 Gen10
  • Two Xeon 6 core types in one chassis: seven E-core parts of 64 to 144 cores for dense throughput, and 27 P-core parts of 8 to 86 cores for per-core speed.
03 — By workload

Where each one pulls ahead

Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.

VirtualisationDL380 Gen10: 56 cores with 3 TB. DL380 Gen12: 288 cores with 8 TB.DL380 Gen12
Databases & in-memoryMemory ceiling 3 TB against 8 TB, across 24 and 32 DIMM slots.DL380 Gen12
Storage density24 bays in 2U against 36 in 2U.DL380 Gen12
AI & acceleration8 accelerators against 8 in the vendor documents.Line ball
Network throughputFastest card listed: 100 GbE class against 400 GbE class.DL380 Gen12
04 — Specifications

Side by side, differences first

Everything both documents state, grouped. The default view hides rows where the two machines are identical.

Processors

Every processor each vendor lists for the model, from its own document.

SpecificationDL380 Gen10DL380 Gen12
Processors listed11334
Most cores per processor28144
Highest processor TDP205 W350 W
Processor families2nd Gen Intel Xeon Scalable (Platinum) · 1st Gen Intel Xeon Scalable (Platinum) · 2nd Gen Intel Xeon Scalable (Gold) · 1st Gen Intel Xeon Scalable (Gold) · 2nd Gen Intel Xeon Scalable (Silver) · 1st Gen Intel Xeon Scalable (Silver) · 2nd Gen Intel Xeon Scalable (Bronze) · 1st Gen Intel Xeon Scalable (Bronze)Xeon 6 E-core · Xeon 6 P-core

Memory

SpecificationDL380 Gen10DL380 Gen12
DIMM slots2432
Slots per processor1216
Largest module listed512 GB256 GB
Fastest rated speed2,933 MT/s6,400 MT/s
Memory typesRDIMM DDR4-2933 (2nd Gen Intel Xeon Scalable only) · RDIMM DDR4-2666 (1st Gen Intel Xeon Scalable only) · LRDIMM DDR4-2933 · Intel Optane Persistent Memory for HPE (2666 MT/s) + 1 moreRDIMM DDR5-6400

Storage

Bay counts are the maximum each document states, including rear and mid-chassis positions.

SpecificationDL380 Gen10DL380 Gen12
Maximum bays2436
Documented layouts1513
Bay sizes2.5-inch · 3.5-inch2.5-inch · E3.S · 3.5-inch
Boot devicesHPE NS204i-p x2 Lanes NVMe PCIe3 x8 OS Boot Device · 2 x M.2 SATA on the default primary riser; RAID 1 requires HPE FIO Enable Smart Array SW RAID (784308-B21) · HPE Smart Array S100i SR Gen10 SW RAID (embedded, 14 SATA ports of which 12 accessible) + 1 moreHPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device + 3 more
Storage controllers1514

Accelerators & I/O

SpecificationDL380 Gen10DL380 Gen12
Double-wide cards listed144
OCP slots02
Network cards listed2239

Power & platform

SpecificationDL380 Gen10DL380 Gen12
Power-supply options85
Output range500–2,200 W800–2,200 W
Input typesAC · −48 V DC · 277 VAC / HVDCAC · −48 V DC
ManagementHPE iLO 5HPE iLO 7
Chassis depthVendors measure depth differently — see each data sheetSFF drives: 8.73 x 44.54 x 67.94 cm (3.44 x 17.54 x 26.75 in)SFF/EDSFF CTO: 72.70 cm (28.62 in)
05 — The data

Processors, memory, bays and power

The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.

DL380 Gen10: processors by cores and TDP

HPE ProLiant DL380 Gen10 processors0816243250 W100 W150 W200 W250 WCores per processorIntel Xeon Platinum 8280 — 28 cores · 205 W · 2.7 GHz base · 38.5 MB cache · 2933Intel Xeon Platinum 8280L — 28 cores · 205 W · 2.7 GHz base · 38.5 MB cache · 2933Intel Xeon Platinum 8280M — 28 cores · 205 W · 2.7 GHz base · 38.5 MB cache · 2933Intel Xeon Platinum 8276 — 28 cores · 165 W · 2.2 GHz base · 38.5 MB cache · 2933Intel Xeon Platinum 8276L — 28 cores · 165 W · 2.2 GHz base · 38.5 MB cache · 2933Intel Xeon Platinum 8276M — 28 cores · 165 W · 2.2 GHz base · 38.5 MB cache · 2933Intel Xeon Platinum 8270 — 26 cores · 205 W · 2.7 GHz base · 35.75 MB cache · 2933Intel Xeon Platinum 8268 — 24 cores · 205 W · 2.9 GHz base · 35.75 MB cache · 2933Intel Xeon Platinum 8260 — 24 cores · 165 W · 2.4 GHz base · 35.75 MB cache · 2933Intel Xeon Platinum 8260L — 24 cores · 165 W · 2.4 GHz base · 35.75 MB cache · 2933Intel Xeon Platinum 8260M — 24 cores · 165 W · 2.4 GHz base · 35.75 MB cache · 2933Intel Xeon Platinum 8260Y — 24 cores · 165 W · 2.4 GHz base · 35.75 MB cache · 2933Intel Xeon Platinum 8253 — 16 cores · 125 W · 2.2 GHz base · 22 MB cache · 2933Intel Xeon Platinum 8256 — 4 cores · 105 W · 3.8 GHz base · 16.5 MB cache · 2933Intel Xeon Platinum 8180 — 28 cores · 205 W · 2.5 GHz base · 38.5 MB cache · 2666Intel Xeon Platinum 8180M — 28 cores · 205 W · 2.5 GHz base · 38.5 MB cache · 2666Intel Xeon Platinum 8176 — 28 cores · 165 W · 2.1 GHz base · 38.5 MB cache · 2666Intel Xeon Platinum 8170 — 26 cores · 165 W · 2.1 GHz base · 35.75 MB cache · 2666Intel Xeon Platinum 8164 — 26 cores · 150 W · 2 GHz base · 35.75 MB cache · 2666Intel Xeon Platinum 8168 — 24 cores · 205 W · 2.7 GHz base · 33 MB cache · 2666Intel Xeon Platinum 8165 — 24 cores · 205 W · 2.3 GHz base · 33 MB cache · 2666Intel Xeon Platinum 8160 — 24 cores · 150 W · 2.1 GHz base · 33 MB cache · 2666Intel Xeon Platinum 8153 — 16 cores · 125 W · 2 GHz base · 22 MB cache · 2666Intel Xeon Platinum 8158 — 12 cores · 150 W · 3 GHz base · 24.75 MB cache · 2666Intel Xeon Platinum 8156 — 4 cores · 105 W · 3.6 GHz base · 16.5 MB cache · 2666Intel Xeon Gold 6258R — 28 cores · 205 W · 2.7 GHz base · 38.5 MB cache · 2933Intel Xeon Gold 6238R — 28 cores · 165 W · 2.2 GHz base · 38.5 MB cache · 2933Intel Xeon Gold 6230R — 26 cores · 150 W · 2.1 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6248R — 24 cores · 205 W · 3 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6240R — 24 cores · 165 W · 2.4 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6212U — 24 cores · 165 W · 2.4 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6252 — 24 cores · 150 W · 2.1 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6252N — 24 cores · 150 W · 2.3 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 5220R — 24 cores · 150 W · 2.2 GHz base · 35.75 MB cache · 2666Intel Xeon Gold 6262V — 24 cores · 135 W · 1.9 GHz base · 33 MB cache · 2933Intel Xeon Gold 6238 — 22 cores · 140 W · 2.1 GHz base · 30.25 MB cache · 2933Intel Xeon Gold 6238L — 22 cores · 140 W · 2.1 GHz base · 30.25 MB cache · 2933Intel Xeon Gold 6238M — 22 cores · 140 W · 2.1 GHz base · 30.25 MB cache · 2933Intel Xeon Gold 6242R — 20 cores · 205 W · 3.1 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6248 — 20 cores · 150 W · 2.5 GHz base · 27.5 MB cache · 2933Intel Xeon Gold 6210U — 20 cores · 150 W · 2.5 GHz base · 27.5 MB cache · 2933Intel Xeon Gold 6230 — 20 cores · 125 W · 2.1 GHz base · 27.5 MB cache · 2933Intel Xeon Gold 6230N — 20 cores · 125 W · 2.3 GHz base · 27.5 MB cache · 2933Intel Xeon Gold 6209U — 20 cores · 125 W · 2.1 GHz base · 27.5 MB cache · 2933Intel Xeon Gold 5218R — 20 cores · 125 W · 2.1 GHz base · 27.5 MB cache · 2666Intel Xeon Gold 6222V — 20 cores · 115 W · 1.8 GHz base · 27.5 MB cache · 2933Intel Xeon Gold 6254 — 18 cores · 200 W · 3.1 GHz base · 24.75 MB cache · 2933Intel Xeon Gold 6240 — 18 cores · 150 W · 2.6 GHz base · 24.75 MB cache · 2933Intel Xeon Gold 6240L — 18 cores · 150 W · 2.6 GHz base · 24.75 MB cache · 2933Intel Xeon Gold 6240M — 18 cores · 150 W · 2.6 GHz base · 24.75 MB cache · 2933Intel Xeon Gold 6240Y — 18 cores · 150 W · 2.6 GHz base · 24.75 MB cache · 2933Intel Xeon Gold 5220 — 18 cores · 125 W · 2.2 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 5220S — 18 cores · 125 W · 2.7 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6246R — 16 cores · 205 W · 3.4 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6242 — 16 cores · 150 W · 2.8 GHz base · 22 MB cache · 2933Intel Xeon Gold 6226R — 16 cores · 150 W · 2.9 GHz base · 22 MB cache · 2933Intel Xeon Gold 6208U — 16 cores · 150 W · 2.9 GHz base · 22 MB cache · 2933Intel Xeon Gold 5218 — 16 cores · 125 W · 2.3 GHz base · 22 MB cache · 2666Intel Xeon Gold 5218B — 16 cores · 125 W · 2.3 GHz base · 22 MB cache · 2666Intel Xeon Gold 5218N — 16 cores · 110 W · 2.3 GHz base · 22 MB cache · 2666Intel Xeon Gold 6256 — 12 cores · 205 W · 3.6 GHz base · 33 MB cache · 2933Intel Xeon Gold 6246 — 12 cores · 165 W · 3.3 GHz base · 24.75 MB cache · 2933Intel Xeon Gold 6226 — 12 cores · 125 W · 2.7 GHz base · 19.25 MB cache · 2933Intel Xeon Gold 5215 — 10 cores · 85 W · 2.5 GHz base · 13.75 MB cache · 2666Intel Xeon Gold 5215L — 10 cores · 85 W · 2.5 GHz base · 13.75 MB cache · 2666Intel Xeon Gold 5215M — 10 cores · 85 W · 2.5 GHz base · 13.75 MB cache · 2666Intel Xeon Gold 6250 — 8 cores · 185 W · 3.9 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6250L — 8 cores · 185 W · 3.9 GHz base · 35.75 MB cache · 2933Intel Xeon Gold 6244 — 8 cores · 150 W · 3.6 GHz base · 24.75 MB cache · 2933Intel Xeon Gold 6234 — 8 cores · 130 W · 3.3 GHz base · 24.75 MB cache · 2933Intel Xeon Gold 5217 — 8 cores · 115 W · 3 GHz base · 11 MB cache · 2666Intel Xeon Gold 5222 — 4 cores · 105 W · 3.8 GHz base · 16.5 MB cache · 2933Intel Xeon Gold 6152 — 22 cores · 140 W · 2.1 GHz base · 30.25 MB cache · 2666Intel Xeon Gold 6148 — 20 cores · 150 W · 2.4 GHz base · 27.5 MB cache · 2666Intel Xeon Gold 6138 — 20 cores · 125 W · 2 GHz base · 27.5 MB cache · 2666Intel Xeon Gold 6154 — 18 cores · 200 W · 3 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6150 — 18 cores · 165 W · 2.7 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6140 — 18 cores · 140 W · 2.3 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6143 — 16 cores · 205 W · 2.8 GHz base · 22 MB cache · 2666Intel Xeon Gold 6142 — 16 cores · 150 W · 2.6 GHz base · 22 MB cache · 2666Intel Xeon Gold 6130 — 16 cores · 125 W · 2.1 GHz base · 22 MB cache · 2666Intel Xeon Gold 6132 — 14 cores · 140 W · 2.6 GHz base · 19.25 MB cache · 2666Intel Xeon Gold 5120 — 14 cores · 105 W · 2.2 GHz base · 19.25 MB cache · 2400Intel Xeon Gold 5117 — 14 cores · 105 W · 2 GHz base · 19.25 MB cache · 2400Intel Xeon Gold 6146 — 12 cores · 165 W · 3.2 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6136 — 12 cores · 150 W · 3 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6126 — 12 cores · 125 W · 2.6 GHz base · 19.25 MB cache · 2666Intel Xeon Gold 5118 — 12 cores · 105 W · 2.3 GHz base · 16.5 MB cache · 2400Intel Xeon Gold 5115 — 10 cores · 85 W · 2.4 GHz base · 13.75 MB cache · 2400Intel Xeon Gold 6137 — 8 cores · 205 W · 3.9 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6144 — 8 cores · 150 W · 3.5 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6134 — 8 cores · 130 W · 3.2 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6134M — 8 cores · 130 W · 3.2 GHz base · 24.75 MB cache · 2666Intel Xeon Gold 6128 — 6 cores · 115 W · 3.4 GHz base · 19.25 MB cache · 2666Intel Xeon Gold 5122 — 4 cores · 105 W · 3.6 GHz base · 16.5 MB cache · 2666Intel Xeon Silver 4216 — 16 cores · 100 W · 2.1 GHz base · 22 MB cache · 2400Intel Xeon Silver 4214R — 12 cores · 100 W · 2.4 GHz base · 16.5 MB cache · 2400Intel Xeon Silver 4214 — 12 cores · 85 W · 2.2 GHz base · 16.5 MB cache · 2400Intel Xeon Silver 4214Y — 12 cores · 85 W · 2.2 GHz base · 16.5 MB cache · 2400Intel Xeon Silver 4210R — 10 cores · 100 W · 2.4 GHz base · 13.75 MB cache · 2400Intel Xeon Silver 4210 — 10 cores · 85 W · 2.2 GHz base · 13.75 MB cache · 2400Intel Xeon Silver 4215R — 8 cores · 130 W · 3.2 GHz base · 11 MB cache · 2400Intel Xeon Silver 4215 — 8 cores · 85 W · 2.5 GHz base · 11 MB cache · 2400Intel Xeon Silver 4208 — 8 cores · 85 W · 2.1 GHz base · 11 MB cache · 2400Intel Xeon Silver 4116 — 12 cores · 85 W · 2.1 GHz base · 16.5 MB cache · 2400Intel Xeon Silver 4114 — 10 cores · 85 W · 2.2 GHz base · 13.75 MB cache · 2400Intel Xeon Silver 4110 — 8 cores · 85 W · 2.1 GHz base · 11 MB cache · 2400Intel Xeon Silver 4108 — 8 cores · 85 W · 1.8 GHz base · 11 MB cache · 2400Intel Xeon Silver 4112 — 4 cores · 85 W · 2.6 GHz base · 8.25 MB cache · 2400Intel Xeon Bronze 3206R — 8 cores · 85 W · 1.9 GHz base · 11 MB cache · 2133Intel Xeon Bronze 3204 — 6 cores · 85 W · 1.9 GHz base · 8.25 MB cache · 2133Intel Xeon Bronze 3106 — 8 cores · 85 W · 1.7 GHz base · 11 MB cache · 2133Intel Xeon Bronze 3104 — 6 cores · 85 W · 1.7 GHz base · 8.25 MB cache · 2133828028 cores — the top SKU6262V5.6 W/core — most efficient
2nd Gen Intel Xeon Scalable (Platinum) 141st Gen Intel Xeon Scalable (Platinum) 112nd Gen Intel Xeon Scalable (Gold) 471st Gen Intel Xeon Scalable (Gold) 232nd Gen Intel Xeon Scalable (Silver) 91st Gen Intel Xeon Scalable (Silver) 52nd Gen Intel Xeon Scalable (Bronze) 21st Gen Intel Xeon Scalable (Bronze) 2Bubble size = L3 cache · hover a bubble for the full SKU

DL380 Gen12: processors by cores and TDP

HPE ProLiant Compute DL380 Gen12 processors081624324048566472808896104112120128136144100 W150 W200 W250 W300 W350 WCores per processorIntel Xeon 6780E — 144 cores · 330 W · 2.2 GHz base · 108 MB cache · 6400Intel Xeon 6766E — 144 cores · 250 W · 1.9 GHz base · 108 MB cache · 6400Intel Xeon 6756E — 128 cores · 225 W · 1.8 GHz base · 96 MB cache · 6400Intel Xeon 6746E — 112 cores · 250 W · 2 GHz base · 96 MB cache · 5600Intel Xeon 6731E — 96 cores · 250 W · 2.2 GHz base · 96 MB cache · 5600Intel Xeon 6740E — 96 cores · 250 W · 2.4 GHz base · 96 MB cache · 6400Intel Xeon 6710E — 64 cores · 205 W · 2.4 GHz base · 96 MB cache · 5600Intel Xeon 6787P — 86 cores · 350 W · 2 GHz base · 336 MB cache · 6400Intel Xeon 6788P — 86 cores · 350 W · 2 GHz base · 336 MB cache · 6400Intel Xeon 6762P — 64 cores · 350 W · 2.9 GHz base · 320 MB cache · 6400Intel Xeon 6767P — 64 cores · 350 W · 2.4 GHz base · 336 MB cache · 6400Intel Xeon 6760P — 64 cores · 330 W · 2.2 GHz base · 320 MB cache · 6400Intel Xeon 6768P — 64 cores · 330 W · 2.4 GHz base · 336 MB cache · 6400Intel Xeon 6747P — 48 cores · 330 W · 2.7 GHz base · 288 MB cache · 6400Intel Xeon 6748P — 48 cores · 300 W · 2.5 GHz base · 192 MB cache · 6400Intel Xeon 6740P — 48 cores · 270 W · 2.1 GHz base · 288 MB cache · 6400Intel Xeon 6736P — 36 cores · 205 W · 2 GHz base · 144 MB cache · 6400Intel Xeon 6732P — 32 cores · 350 W · 3.8 GHz base · 144 MB cache · 6400Intel Xeon 6745P — 32 cores · 300 W · 3.1 GHz base · 336 MB cache · 6400Intel Xeon 6737P — 32 cores · 270 W · 2.9 GHz base · 144 MB cache · 6400Intel Xeon 6738P — 32 cores · 270 W · 2.9 GHz base · 144 MB cache · 6400Intel Xeon 6730P — 32 cores · 250 W · 2.5 GHz base · 288 MB cache · 6400Intel Xeon 6530P — 32 cores · 225 W · 2.3 GHz base · 144 MB cache · 6400Intel Xeon 6527P — 24 cores · 255 W · 3 GHz base · 144 MB cache · 6400Intel Xeon 6520P — 24 cores · 210 W · 2.4 GHz base · 144 MB cache · 6400Intel Xeon 6728P — 24 cores · 210 W · 2.7 GHz base · 144 MB cache · 6400Intel Xeon 6725P — 16 cores · 235 W · 3.7 GHz base · 192 MB cache · 6400Intel Xeon 6724P — 16 cores · 210 W · 3.6 GHz base · 72 MB cache · 6400Intel Xeon 6517P — 16 cores · 190 W · 3.2 GHz base · 72 MB cache · 6400Intel Xeon 6515P — 16 cores · 150 W · 2.3 GHz base · 72 MB cache · 6400Intel Xeon 6505P — 12 cores · 150 W · 2.2 GHz base · 48 MB cache · 6400Intel Xeon 6714P — 8 cores · 165 W · 4 GHz base · 48 MB cache · 6400Intel Xeon 6507P — 8 cores · 150 W · 3.5 GHz base · 48 MB cache · 6400Intel Xeon 6503P — 8 cores · 135 W · 2.8 GHz base · 48 MB cache · 64006780E144 cores — the top SKU6766E1.7 W/core — most efficient
Xeon 6 E-core 7Xeon 6 P-core 27Bubble size = L3 cache · hover a bubble for the full SKU

DL380 Gen10: memory with every slot filled

8 GB192 GB16 GB384 GB32 GB768 GB64 GB1.5 TB128 GB3 TB512 GB12 TB24 slots · 12 per processor · each tick = one DIMM

DL380 Gen12: memory with every slot filled

16 GB512 GB32 GB1 TB64 GB2 TB96 GB3 TB128 GB4 TB256 GB8 TB32 slots · 16 per processor · each tick = one DIMM

DL380 Gen10: drive bays

Front panel

24 × 2.5" SAS/SATA at the front — 24 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

DL380 Gen12: drive bays

Front panel

12 × EDSFF NVMe at the front — 12 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

DL380 Gen10: power supplies

05001000150020002500500 W Platinum — Up to 94% efficiency; standard C14 inlet. 100-240 VAC. 1840 BTU/hr at 200 VAC.500Platinum800 W Platinum — Up to 94% efficiency; standard C14 inlet. 100-240 VAC. 2958 BTU/hr at 200 VAC.800Platinum800 W Titanium — Up to 96% efficiency; standard C14 inlet. 200-240 VAC. One of the three part numbers HPE names as meeting the EU/UK Lot 9 96% single-output requirement from 1 January 2024.800Titanium800 W Up to 94% (DC input) — -48VDC input, -40 Vdc to -72 Vdc.800DC800 W Up to 94% (universal AC/DC) — Universal high-voltage AC/DC; supports 277VAC/380VDC inputs (200-277 VAC rated).800DC1600 W Platinum — Up to 94% efficiency; C14 inlet supporting HPE Power Discovery Services (blue connector). 200-240 VAC. 5918 BTU/hr at 200 VAC.1600Platinum1600 W Up to 94% (DC input) — -48VDC. Requires power cable kit P22173-B21 or power lug kit P36877-B21. Not supported with Intel Optane Persistent Memory (128/256/512 GB).1600DC2200 W Titanium — HPE 1800W-2200W Flex Slot Titanium; up to 96% efficiency and EU Lot 9 compliant. Rated output varies with input: 1800W at 200 VAC, 1900W at 208 VAC, 2000W at 220 VAC, 2100W at 230 VAC, 2200W at 240 VAC.2200TitaniumWatts · dashed line = output at 100–120 V low line
AC277 VAC / HVDC−48 V DC

DL380 Gen12: power supplies

05001000150020002500800 W Platinum — HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit. Input voltage not printed. Not compatible with Energy Star 4.0 compliance (doc: 'Platinum Power Supply 800W & 1600W are not compatible').800Platinum1000 W Titanium — HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit. Named in the ErP Lot 9 section as 96% efficient. Input voltage not printed.1000Titanium1600 W null — HPE 1600W Flex Slot -48VDC Hot Plug Power Supply Kit; no efficiency rating printed. Requires HPE 1600W -48VDC Power Cable Lug Kit (P36877-B21) OR the 1600W DC PSU Power Cable Kit.1600DC1600 W Platinum — HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit. '1600W Power supplies only support high line voltage (200 VAC to 240 VAC).' Not compatible with Energy Star 4.0 compliance.1600Platinum2200 W Titanium — Printed as 'HPE 1800W-2200W Flex Slot Titanium Hot Plug Power Supply Kit' (watts recorded as upper figure; per-voltage ratings not printed). Named in the ErP Lot 9 section as 96% efficient.2200TitaniumWatts · dashed line = output at 100–120 V low line
AC−48 V DC
07 — Questions

DL380 Gen10 vs DL380 Gen12, answered

Is the DL380 Gen10 or the DL380 Gen12 the faster server?

Neither document publishes benchmark results, so this page compares what they do state. The DL380 Gen10 lists 113 processors up to 28 cores at 205 W; the DL380 Gen12 lists 34 up to 144 cores at 350 W. Fully populated that is 56 cores against 288.

Which holds more memory?

The DL380 Gen10 has 24 DIMM slots and a stated ceiling of 3.0 TB. The DL380 Gen12 has 32 and 8.0 TB.

Which takes more drives?

DL380 Gen10: 24 bays across 15 documented layouts. DL380 Gen12: 36 across 13. Counts include rear and mid-chassis positions where the vendor documents them.

Can either take GPUs?

DL380 Gen10: up to 8 accelerators, 14 double-wide cards listed. DL380 Gen12: up to 8, 4 double-wide listed.

Do they share any processors?

No. The two documents list different processors, so a like-for-like processor build is not possible across these two.

Where these figures come from. DL380 Gen10: HPE ProLiant DL380 Gen10 Server QuickSpecs (a00008180enw, Version 77, 16 June 2025) (HPE document). DL380 Gen12: HPE ProLiant DL380 Gen12 QuickSpecs (Version 19 - 08-Sep-2026) (HPE document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.

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