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Head-to-head · every figure from the vendor documents

HPE DL380 Gen12 vs Lenovo SR665 V3

A specification-by-specification comparison of the HPE ProLiant Compute DL380 Gen12 and the Lenovo ThinkSystem SR665 V3, built from HPE’s and Lenovo’s own documents. 2 headline measures favour the DL380 Gen12, 3 favour the SR665 V3, and they share no processors.

Bottom line. DL380 Gen12 leads on virtualisation, databases and in-memory work, AI and acceleration. SR665 V3 leads on storage density. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.

HPE ProLiant Compute DL380 Gen12 2U server, front view: 24 SFF bays in three 8-bay boxes, USB-C iLO port, USB port and health LEDs
HPE ProLiant
DL380 Gen12
2U Rack2 sockets32 DIMMHPE iLO 7
Configure the DL380 Gen12 →Full data sheet
VS
Lenovo ThinkSystem SR665 V3 front: 24 numbered 2.5-inch drive bays, VGA and diagnostics ports at left, two USB ports at right
Lenovo ThinkSystem
SR665 V3
2U Rack2 sockets24 DIMMXClarity Controller 2
Configure the SR665 V3 →Full data sheet
01 — Scoreboard

The measures that decide it

Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.

2
Processor sockets
2
288
Cores, fully populated
Largest listed processor × its socket count
Higher320
8 TBHigher
Memory ceiling
As each document states it
6 TB
36
Drive bays
Higher40
Up to 8Higher
Accelerators
Up to 7
2,200 W
Largest power supply
Higher2,600 W
2U Rack
Rack height
2U Rack
400 GbE class
Fastest network option
400 GbE class
02 — Verdict

Which one, and why

Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.

Choose the DL380 Gen12 if…

  • Memory ceiling: 8 TB against 6 TB on the SR665 V3
  • Accelerators: Up to 8 against Up to 7 on the SR665 V3
  • Two Xeon 6 core types in one chassis: seven E-core parts of 64 to 144 cores for dense throughput, and 27 P-core parts of 8 to 86 cores for per-core speed.

Choose the SR665 V3 if…

  • Cores, fully populated: 320 against 288 on the DL380 Gen12
  • Drive bays: 40 against 36 on the DL380 Gen12
  • Largest power supply: 2,600 W against 2,200 W on the DL380 Gen12
  • Lenovo lists 48 processors across two EPYC generations in one chassis, spanning 8 cores (EPYC 9015) to 160 (EPYC 9845) at up to 400 W.
03 — By workload

Where each one pulls ahead

Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.

VirtualisationDL380 Gen12: 288 cores with 8 TB. SR665 V3: 320 cores with 6 TB.DL380 Gen12
Databases & in-memoryMemory ceiling 8 TB against 6 TB, across 32 and 24 DIMM slots.DL380 Gen12
Storage density36 bays in 2U against 40 in 2U.SR665 V3
AI & acceleration8 accelerators against 7 in the vendor documents.DL380 Gen12
Network throughputFastest card listed: 400 GbE class against 400 GbE class.Line ball
04 — Specifications

Side by side, differences first

Everything both documents state, grouped. The default view hides rows where the two machines are identical.

Processors

Every processor each vendor lists for the model, from its own document.

SpecificationDL380 Gen12SR665 V3
Processors listed3448
Most cores per processor144160
Highest processor TDP350 W400 W
Processor familiesXeon 6 E-core · Xeon 6 P-coreAMD EPYC 9005 · AMD EPYC 9004

Memory

SpecificationDL380 Gen12SR665 V3
DIMM slots3224
Slots per processor1612
Memory typesRDIMM DDR5-6400RDIMM DDR5-6400 (5th Gen EPYC) · RDIMM DDR5-4800 (4th Gen EPYC) · 9x4 RDIMM · 3DS RDIMM DDR5-6400

Storage

Bay counts are the maximum each document states, including rear and mid-chassis positions.

SpecificationDL380 Gen12SR665 V3
Maximum bays3640
Documented layouts1319
Bay sizes2.5-inch · E3.S · 3.5-inch3.5-inch · 2.5-inch
Boot devicesHPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device · HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device + 3 moreM.2 SATA/x4 NVMe 2-Bay Adapter (4Y37A79663) · M.2 NVMe 2-Bay RAID Adapter (4Y37A09750) · M.2 RAID B540i-2i SATA/NVMe Adapter (4Y37A90063) + 4 more
Storage controllers1420

Accelerators & I/O

SpecificationDL380 Gen12SR665 V3
Accelerators supportedUp to 8Up to 7
Double-wide cards listed46
OCP slots21
PCIe network slots812
Network cards listed3932

Power & platform

SpecificationDL380 Gen12SR665 V3
Power-supply options510
Output range800–2,200 W750–2,600 W
ManagementHPE iLO 7XClarity Controller 2
Chassis depthVendors measure depth differently — see each data sheetSFF/EDSFF CTO: 72.70 cm (28.62 in)766 mm
05 — The data

Processors, memory, bays and power

The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.

DL380 Gen12: processors by cores and TDP

HPE ProLiant Compute DL380 Gen12 processors081624324048566472808896104112120128136144100 W150 W200 W250 W300 W350 WCores per processorIntel Xeon 6780E — 144 cores · 330 W · 2.2 GHz base · 108 MB cache · DDR5-6400Intel Xeon 6766E — 144 cores · 250 W · 1.9 GHz base · 108 MB cache · DDR5-6400Intel Xeon 6756E — 128 cores · 225 W · 1.8 GHz base · 96 MB cache · DDR5-6400Intel Xeon 6746E — 112 cores · 250 W · 2 GHz base · 96 MB cache · DDR5-5600Intel Xeon 6731E — 96 cores · 250 W · 2.2 GHz base · 96 MB cache · DDR5-5600Intel Xeon 6740E — 96 cores · 250 W · 2.4 GHz base · 96 MB cache · DDR5-6400Intel Xeon 6710E — 64 cores · 205 W · 2.4 GHz base · 96 MB cache · DDR5-5600Intel Xeon 6787P — 86 cores · 350 W · 2 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6788P — 86 cores · 350 W · 2 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6762P — 64 cores · 350 W · 2.9 GHz base · 320 MB cache · DDR5-6400Intel Xeon 6767P — 64 cores · 350 W · 2.4 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6760P — 64 cores · 330 W · 2.2 GHz base · 320 MB cache · DDR5-6400Intel Xeon 6768P — 64 cores · 330 W · 2.4 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6747P — 48 cores · 330 W · 2.7 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6748P — 48 cores · 300 W · 2.5 GHz base · 192 MB cache · DDR5-6400Intel Xeon 6740P — 48 cores · 270 W · 2.1 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6736P — 36 cores · 205 W · 2 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6732P — 32 cores · 350 W · 3.8 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6745P — 32 cores · 300 W · 3.1 GHz base · 336 MB cache · DDR5-6400Intel Xeon 6737P — 32 cores · 270 W · 2.9 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6738P — 32 cores · 270 W · 2.9 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6730P — 32 cores · 250 W · 2.5 GHz base · 288 MB cache · DDR5-6400Intel Xeon 6530P — 32 cores · 225 W · 2.3 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6527P — 24 cores · 255 W · 3 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6520P — 24 cores · 210 W · 2.4 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6728P — 24 cores · 210 W · 2.7 GHz base · 144 MB cache · DDR5-6400Intel Xeon 6725P — 16 cores · 235 W · 3.7 GHz base · 192 MB cache · DDR5-6400Intel Xeon 6724P — 16 cores · 210 W · 3.6 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6517P — 16 cores · 190 W · 3.2 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6515P — 16 cores · 150 W · 2.3 GHz base · 72 MB cache · DDR5-6400Intel Xeon 6505P — 12 cores · 150 W · 2.2 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6714P — 8 cores · 165 W · 4 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6507P — 8 cores · 150 W · 3.5 GHz base · 48 MB cache · DDR5-6400Intel Xeon 6503P — 8 cores · 135 W · 2.8 GHz base · 48 MB cache · DDR5-64006780E144 cores — the top SKU6766E1.7 W/core — most efficient
Xeon 6 E-core 7Xeon 6 P-core 27Bubble size = L3 cache · hover a bubble for the full SKU

SR665 V3: processors by cores and TDP

Lenovo ThinkSystem SR665 V3 processors081624324048566472808896104112120128136144152160100 W150 W200 W250 W300 W350 W400 WCores per processorAMD EPYC 9845 — 160 cores / 320 threads · 390 W · 2.1 GHz base · 320 MB cache · DDR5-6400AMD EPYC 9825 — 144 cores / 288 threads · 390 W · 2.2 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9745 — 128 cores / 256 threads · 400 W · 2.4 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9655 — 96 cores / 192 threads · 400 W · 2.6 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9655P — 96 cores / 192 threads · 400 W · 2.6 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9645 — 96 cores / 192 threads · 320 W · 2.3 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9565 — 72 cores / 144 threads · 400 W · 3.15 GHz base · 384 MB cache · DDR5-6400AMD EPYC 9575F — 64 cores / 128 threads · 400 W · 3.3 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9555 — 64 cores / 128 threads · 360 W · 3.2 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9555P — 64 cores / 128 threads · 360 W · 3.2 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9535 — 64 cores / 128 threads · 300 W · 2.4 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9475F — 48 cores / 96 threads · 400 W · 3.65 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9455 — 48 cores / 96 threads · 300 W · 3.15 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9455P — 48 cores / 96 threads · 300 W · 3.15 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9365 — 36 cores / 72 threads · 300 W · 3.4 GHz base · 192 MB cache · DDR5-6400AMD EPYC 9375F — 32 cores / 64 threads · 320 W · 3.8 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9355 — 32 cores / 64 threads · 280 W · 3.55 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9355P — 32 cores / 64 threads · 280 W · 3.55 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9335 — 32 cores / 64 threads · 210 W · 3 GHz base · 128 MB cache · DDR5-6400AMD EPYC 9275F — 24 cores / 48 threads · 320 W · 4.1 GHz base · 256 MB cache · DDR5-6400AMD EPYC 9255 — 24 cores / 48 threads · 200 W · 3.25 GHz base · 128 MB cache · DDR5-6400AMD EPYC 9175F — 16 cores / 32 threads · 320 W · 4.2 GHz base · 512 MB cache · DDR5-6400AMD EPYC 9135 — 16 cores / 32 threads · 200 W · 3.65 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9115 — 16 cores / 32 threads · 125 W · 2.6 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9015 — 8 cores / 16 threads · 125 W · 3.6 GHz base · 64 MB cache · DDR5-6400AMD EPYC 9754 — 128 cores / 256 threads · 360 W · 2.25 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9734 — 112 cores / 224 threads · 340 W · 2.2 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9684X — 96 cores / 192 threads · 400 W · 2.55 GHz base · 1150 MB cache · DDR5-4800AMD EPYC 9654 — 96 cores / 192 threads · 360 W · 2.4 GHz base · 384 MB cache · DDR5-4800AMD EPYC 9654P — 96 cores / 192 threads · 360 W · 2.4 GHz base · 384 MB cache · DDR5-4800AMD EPYC 9634 — 84 cores / 168 threads · 290 W · 2.25 GHz base · 384 MB cache · DDR5-4800AMD EPYC 9554 — 64 cores / 128 threads · 360 W · 3.1 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9554P — 64 cores / 128 threads · 360 W · 3.1 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9534 — 64 cores / 128 threads · 280 W · 2.45 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9474F — 48 cores / 96 threads · 360 W · 3.6 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9454 — 48 cores / 96 threads · 290 W · 2.75 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9454P — 48 cores / 96 threads · 290 W · 2.75 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9374F — 32 cores / 64 threads · 320 W · 3.85 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9384X — 32 cores / 64 threads · 320 W · 3.1 GHz base · 768 MB cache · DDR5-4800AMD EPYC 9354 — 32 cores / 64 threads · 280 W · 3.25 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9354P — 32 cores / 64 threads · 280 W · 3.25 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9334 — 32 cores / 64 threads · 210 W · 2.7 GHz base · 128 MB cache · DDR5-4800AMD EPYC 9274F — 24 cores / 48 threads · 320 W · 4.05 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9224 — 24 cores / 48 threads · 200 W · 2.5 GHz base · 64 MB cache · DDR5-4800AMD EPYC 9254 — 24 cores / 48 threads · 200 W · 2.9 GHz base · 128 MB cache · DDR5-4800AMD EPYC 9174F — 16 cores / 32 threads · 320 W · 4.1 GHz base · 256 MB cache · DDR5-4800AMD EPYC 9184X — 16 cores / 32 threads · 320 W · 3.55 GHz base · 768 MB cache · DDR5-4800AMD EPYC 9124 — 16 cores / 32 threads · 200 W · 3 GHz base · 64 MB cache · DDR5-4800EPYC 9845160 cores · 2.4 W/core — top SKU and most efficient
AMD EPYC 9005 25AMD EPYC 9004 23Bubble size = L3 cache · hover a bubble for the full SKU

DL380 Gen12: memory with every slot filled

16 GB512 GB32 GB1 TB64 GB2 TB96 GB3 TB128 GB4 TB256 GB8 TB32 slots · 16 per processor · each tick = one DIMM

SR665 V3: memory with every slot filled

16 GB384 GB32 GB768 GB64 GB1.5 TB96 GB2.3 TB128 GB3 TB256 GB6 TB24 slots · 12 per processor · each tick = one DIMM

DL380 Gen12: drive bays

Front panel

12 × EDSFF NVMe at the front — 12 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

SR665 V3: drive bays

Front panel

24 × 2.5" SAS/SATA at the front — 24 bays in total.

SAS/SATANVMeSAS/SATA + NVMe

DL380 Gen12: power supplies

05001000150020002500800 W Platinum — HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit. Input voltage not printed. Not compatible with Energy Star 4.0 compliance (doc: 'Platinum Power Supply 800W & 1600W are not compatible').800Platinum1000 W Titanium — HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit. Named in the ErP Lot 9 section as 96% efficient. Input voltage not printed.1000Titanium1600 W null — HPE 1600W Flex Slot -48VDC Hot Plug Power Supply Kit; no efficiency rating printed. Requires HPE 1600W -48VDC Power Cable Lug Kit (P36877-B21) OR the 1600W DC PSU Power Cable Kit.1600DC1600 W Platinum — HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit. '1600W Power supplies only support high line voltage (200 VAC to 240 VAC).' Not compatible with Energy Star 4.0 compliance.1600Platinum2200 W Titanium — Printed as 'HPE 1800W-2200W Flex Slot Titanium Hot Plug Power Supply Kit' (watts recorded as upper figure; per-voltage ratings not printed). Named in the ErP Lot 9 section as 96% efficient.2200TitaniumWatts · dashed line = output at 100–120 V low line
AC−48 V DC

SR665 V3: power supplies

050010001500200025003000750 W Platinum — AC input power - 80 PLUS Platinum efficiency; input 230V/115V; max quantity 2750Platinum750 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 2750Titanium750 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 2750Titanium1100 W n/a (DC input) — -48V DC input power; input -48V DC; max quantity 21100DC1100 W Platinum — AC input power - 80 PLUS Platinum efficiency; input 230V/115V; max quantity 21100Platinum1100 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 21100Titanium1800 W Platinum — AC input power - 80 PLUS Platinum efficiency; input 230V; max quantity 21800Platinum1800 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 21800Titanium2400 W Platinum — AC input power - 80 PLUS Platinum efficiency; input 230V; max quantity 22400Platinum2600 W Titanium — AC input power - 80 PLUS Titanium efficiency; input 230V; max quantity 22600TitaniumWatts · dashed line = output at 100–120 V low line
AC−48 V DC
07 — Questions

DL380 Gen12 vs SR665 V3, answered

Is the DL380 Gen12 or the SR665 V3 the faster server?

Neither document publishes benchmark results, so this page compares what they do state. The DL380 Gen12 lists 34 processors up to 144 cores at 350 W; the SR665 V3 lists 48 up to 160 cores at 400 W. Fully populated that is 288 cores against 320.

Which holds more memory?

The DL380 Gen12 has 32 DIMM slots and a stated ceiling of 8.0 TB. The SR665 V3 has 24 and 6 TB.

Which takes more drives?

DL380 Gen12: 36 bays across 13 documented layouts. SR665 V3: 40 across 19. Counts include rear and mid-chassis positions where the vendor documents them.

Can either take GPUs?

DL380 Gen12: up to 8 accelerators, 4 double-wide cards listed. SR665 V3: up to 7, 6 double-wide listed.

Do they share any processors?

No. The two documents list different processors, so a like-for-like processor build is not possible across these two.

Where these figures come from. DL380 Gen12: HPE ProLiant DL380 Gen12 QuickSpecs (Version 19 - 08-Sep-2026) (HPE document). SR665 V3: Lenovo ThinkSystem SR665 V3 Server Product Guide (publication date is not printed in the text export; guide contains 'New as of July 2026' notes) (Lenovo document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.

Other comparisons in this class

R760 vs SR665 V3Dell vs LenovoR7625 vs DL380 Gen12Dell vs HPER7625 vs SR665 V3Dell vs LenovoR770 vs DL380 Gen12Dell vs HPER770 vs SR665 V3Dell vs LenovoR770AP vs SR665 V3Dell vs LenovoR7725 vs DL380 Gen12Dell vs HPER7725 vs SR665 V3Dell vs Lenovo

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