Head-to-head · every figure from the vendor documents
HPE DL380 Gen10 vs Lenovo SR650 V3
A specification-by-specification comparison of the HPE ProLiant DL380 Gen10 and the Lenovo ThinkSystem SR650 V3, built from HPE’s and Lenovo’s own documents. None of the headline measures favour the DL380 Gen10; 5 favour the SR650 V3, and they share no processors.
Bottom line. SR650 V3 leads on virtualisation, databases and in-memory work, storage density, network throughput. Neither vendor publishes benchmarks for these machines, so every call here is made on what their documents state.
Each row is a figure both vendors publish. Bars show the split between the two; a badge marks the larger figure, which is not always the better buy — a shallower chassis or a lower power ceiling can matter more.
DL380 Gen102
Processor sockets
SR650 V32
DL380 Gen1056
Cores, fully populated
Largest listed processor × its socket count
SR650 V3128Higher
DL380 Gen103 TB
Memory ceiling
As each document states it
SR650 V38 TBHigher
DL380 Gen1024
Drive bays
SR650 V340Higher
DL380 Gen10Up to 8
Accelerators
SR650 V3Up to 8
DL380 Gen102,200 W
Largest power supply
SR650 V32,600 WHigher
DL380 Gen102U Rack
Rack height
SR650 V32U Rack
DL380 Gen10100 GbE class
Fastest network option
SR650 V3200 GbE classHigher
02 — Verdict
Which one, and why
Drawn from the measures above and each model’s own data sheet. Neither vendor publishes benchmark results for these servers, so nothing here claims one is “faster”.
Choose the DL380 Gen10 if…
Expansion is the whole argument for this chassis. Three riser positions carry as many as eight PCIe 3.0 slots, and the pair of x16/x16/x16 GPU riser kits each take three single-width accelerators — six across two processors. The 1U DL360 Gen10, built from the identical processor table, reaches three slots in total.
Choose the SR650 V3 if…
Cores, fully populated: 128 against 56 on the DL380 Gen10
Memory ceiling: 8 TB against 3 TB on the DL380 Gen10
Drive bays: 40 against 24 on the DL380 Gen10
Three drive zones — front, mid-chassis and rear — take the 2U chassis to 40 × 2.5-inch or 20 × 3.5-inch bays, and up to 36 NVMe drives can each run on a dedicated x4 link with no oversubscription.
03 — By workload
Where each one pulls ahead
Calls made on documented capacity only — cores, memory, bays, accelerators and network options — with the figures behind each one shown.
VirtualisationDL380 Gen10: 56 cores with 3 TB. SR650 V3: 128 cores with 8 TB.SR650 V3
Databases & in-memoryMemory ceiling 3 TB against 8 TB, across 24 and 32 DIMM slots.SR650 V3
Storage density24 bays in 2U against 40 in 2U.SR650 V3
AI & acceleration8 accelerators against 8 in the vendor documents.Line ball
Network throughputFastest card listed: 100 GbE class against 200 GbE class.SR650 V3
04 — Specifications
Side by side, differences first
Everything both documents state, grouped. The default view hides rows where the two machines are identical.
Processors
Every processor each vendor lists for the model, from its own document.
Specification
DL380 Gen10
SR650 V3
Processors listed
113
84
Most cores per processor
28
64
Highest processor TDP
205 W
385 W
Processor families
2nd Gen Intel Xeon Scalable (Platinum) · 1st Gen Intel Xeon Scalable (Platinum) · 2nd Gen Intel Xeon Scalable (Gold) · 1st Gen Intel Xeon Scalable (Gold) · 2nd Gen Intel Xeon Scalable (Silver) · 1st Gen Intel Xeon Scalable (Silver) · 2nd Gen Intel Xeon Scalable (Bronze) · 1st Gen Intel Xeon Scalable (Bronze)
5th Gen Xeon Scalable · 4th Gen Xeon Scalable
Memory
Specification
DL380 Gen10
SR650 V3
DIMM slots
24
32
Slots per processor
12
16
Largest module listed
512 GB
256 GB
Fastest rated speed
2,933 MT/s
5,600 MT/s
Memory types
RDIMM DDR4-2933 (2nd Gen Intel Xeon Scalable only) · RDIMM DDR4-2666 (1st Gen Intel Xeon Scalable only) · LRDIMM DDR4-2933 · Intel Optane Persistent Memory for HPE (2666 MT/s) + 1 more
Chassis depthVendors measure depth differently — see each data sheet
SFF drives: 8.73 x 44.54 x 67.94 cm (3.44 x 17.54 x 26.75 in)
766 mm
05 — The data
Processors, memory, bays and power
The same charts each data sheet carries, drawn to the same scale so the two ranges can be read against each other.
DL380 Gen10: processors by cores and TDP
2nd Gen Intel Xeon Scalable (Platinum) 141st Gen Intel Xeon Scalable (Platinum) 112nd Gen Intel Xeon Scalable (Gold) 471st Gen Intel Xeon Scalable (Gold) 232nd Gen Intel Xeon Scalable (Silver) 91st Gen Intel Xeon Scalable (Silver) 52nd Gen Intel Xeon Scalable (Bronze) 21st Gen Intel Xeon Scalable (Bronze) 2Bubble size = L3 cache · hover a bubble for the full SKU
SR650 V3: processors by cores and TDP
5th Gen Xeon Scalable 324th Gen Xeon Scalable 52Bubble size = L3 cache · hover a bubble for the full SKU
DL380 Gen10: memory with every slot filled
SR650 V3: memory with every slot filled
DL380 Gen10: drive bays
Front panel
24 × 2.5" SAS/SATA at the front — 24 bays in total.
SAS/SATANVMeSAS/SATA + NVMe
SR650 V3: drive bays
Front panel
24 × 2.5" SAS/SATA at the front — 24 bays in total.
SAS/SATANVMeSAS/SATA + NVMe
DL380 Gen10: power supplies
AC277 VAC / HVDC−48 V DC
SR650 V3: power supplies
AC−48 V DC
07 — Questions
DL380 Gen10 vs SR650 V3, answered
Is the DL380 Gen10 or the SR650 V3 the faster server?
Neither document publishes benchmark results, so this page compares what they do state. The DL380 Gen10 lists 113 processors up to 28 cores at 205 W; the SR650 V3 lists 84 up to 64 cores at 385 W. Fully populated that is 56 cores against 128.
Which holds more memory?
The DL380 Gen10 has 24 DIMM slots and a stated ceiling of 3.0 TB. The SR650 V3 has 32 and 8 TB.
Which takes more drives?
DL380 Gen10: 24 bays across 15 documented layouts. SR650 V3: 40 across 20. Counts include rear and mid-chassis positions where the vendor documents them.
Can either take GPUs?
DL380 Gen10: up to 8 accelerators, 14 double-wide cards listed. SR650 V3: up to 8, 1 double-wide listed.
Do they share any processors?
No. The two documents list different processors, so a like-for-like processor build is not possible across these two.
Where these figures come from. DL380 Gen10: HPE ProLiant DL380 Gen10 Server QuickSpecs (a00008180enw, Version 77, 16 June 2025) (HPE document). SR650 V3: Lenovo ThinkSystem SR650 V3 Server Product Guide (publication date is not printed in the text export) (Lenovo document). Each claim on this page is derived from those documents, checked page by page on the two data sheets, and carries no pricing.