Technical data sheet · ProLiant Compute Gen12 · 2U single-socket AMD

HPE ProLiant Compute DL345 Gen12Specifications, configurations & comparisons

The ProLiant Compute DL345 Gen12 is HPE’s single-socket 2U for EPYC 9005 only: up to 192 cores, 24 DDR5 slots and three chassis — SFF/E3.S, 8LFF, or a GPU chassis with double-width cards at the front. This sheet sets out what each chassis allows, how memory speed falls as the slots fill, and the cooling and ambient rules behind every build.

2U Rack1 socketAMD EPYC 9005HPE iLO 7

192cores on one socketEPYC 9965 · 500 W default cTDP

6TBDDR5 maximum24 × 256 GB at two DIMMs per channel

36E3.S drive baysor 24 SFF / 12 LFF · 2 SFF rear option

6PCIe 5.0 x16 slotsfull height · OCP 3.0 front and rear

4double-width GPUsfront of the GPU chassis · L4 also at rear

3,200Wlargest PSUM-CRPS Titanium · 1,600 W at 100–127 V

Configure a DL345 Gen12 →Get a UK quote Refurbished alternatives ↓

Every figure checked against the HPE ProLiant Compute DL345 Gen12 QuickSpecs (Version 12 - 03-Aug-2026 (header prints 'Version 12 - August 3, 2026'))

Image: Hewlett Packard Enterprise

Form factor: 2U Rack · 1 socket
Processors: AMD EPYC 9005
Memory: 24 × DDR5 RDIMM · up to 6.0 TB
Drive bays: Up to 36 · 8 drive-cage kits
Expansion: 6 × PCIe · 2 × OCP 3.0
GPUs: Up to 6 · 4 listed
Boot: NS204i · 5 boot options
Management: HPE iLO 7

01 — Overview

The DL345 Gen12 at a glance

Our read of HPE’s documentation: where the DL345 Gen12 is strong, and the limits worth knowing before you spec one.

Strengths

Up to 192 cores behind a single socket, with the 500 W EPYC 9965 and 9755 on HPE’s list.
Two DIMMs on each of the 12 channels: 24 DDR5 slots reach 6 TB, or 3 TB at the faster one-per-channel speed.
Flexible fronts — 36 E3.S, 24 SFF or 12 LFF, with SFF and E3.S boxes allowed side by side — and a 2SFF rear cage offered on all three chassis.
The GPU chassis takes up to four double-width RTX PRO 4500 cards at the front, or two of the 96 GB RTX PRO 6000 Blackwell.
M-CRPS supplies up to 3200 W Titanium, plus −48 V DC units at 1300 W and 2200 W.

Watch-outs

Memory never runs at its DDR5-6400 rating here: 5200 MT/s with up to 12 DIMMs, and 4000 MT/s in HPE’s speed matrix (4400 MT/s in two notes) with 16, 20 or 24.
EPYC 9005 only, and HPE’s memory rules exclude 4800 and 5600 MT/s DIMMs with these processors — only its DDR5-6400 kits are listed.
No mid-tray cages in any chassis: the front tops out at 24 SFF, 36 E3.S or 12 LFF, with two more SFF bays at the rear.
Only five processors (all 240 W or below) escape the Performance heat sink and fans, and 128 GB or 256 GB DIMMs, E3.S cages or GPUs bring back the Performance fans anyway.
Rear L4 cards are rated for 25 °C, and HPE’s matrix changes the usable slots with processor wattage and front storage — at 500 W with a 24 SFF front only slot 1 remains, and a 12 LFF front takes no rear L4 at all.

Processors23 SKUs

Cores / CPU8–192

DIMM slots24

Drive-cage kits8

Max bays36

GPUsup to 6

PSU options7 · to 3,200 W

02 — Processors

23 supported processors, mapped

Twenty-three EPYC 9005 SKUs make up the processor list — there are no 4th Gen parts — topped by the 500 W pair: the 192-core 9965 and the 128-core 9755 with 512 MB of L3. At the other end sit two 125 W parts, the 8-core 9015 and the 16-core 9115. The chart plots all 23 by cores and default cTDP.

Processor landscape — cores × TDP

23 SKUs · 1 family

AMD EPYC 9005 23Bubble size = L3 cache · hover a bubble for the full SKU

Processor explorer

filter · sort · compare

Sort

Processor	Cores / threads	Base	L3 cache	TDP	W / core	Memory
AMD EPYC 9965	192	2.25 GHz	384 MB	500 W	2.6	DDR5-6400
AMD EPYC 9845	160	2.1 GHz	320 MB	390 W	2.4	DDR5-6400
AMD EPYC 9825	144	2.2 GHz	384 MB	390 W	2.7	DDR5-6400
AMD EPYC 9755	128	2.7 GHz	512 MB	500 W	3.9	DDR5-6400
AMD EPYC 9745	128	2.4 GHz	256 MB	400 W	3.1	DDR5-6400
AMD EPYC 9655P	96	2.6 GHz	384 MB	400 W	4.2	DDR5-6400
AMD EPYC 9645	96	2.3 GHz	256 MB	320 W	3.3	DDR5-6400
AMD EPYC 9565	72	3.15 GHz	384 MB	400 W	5.6	DDR5-6400
AMD EPYC 9575F	64	3.3 GHz	256 MB	400 W	6.3	DDR5-6400
AMD EPYC 9555P	64	3.2 GHz	256 MB	360 W	5.6	DDR5-6400
AMD EPYC 9535	64	2.4 GHz	256 MB	300 W	4.7	DDR5-6400
AMD EPYC 9475F	48	3.65 GHz	256 MB	400 W	8.3	DDR5-6400
AMD EPYC 9455P	48	3.15 GHz	256 MB	300 W	6.3	DDR5-6400
AMD EPYC 9365	36	3.4 GHz	192 MB	300 W	8.3	DDR5-6400
AMD EPYC 9375F	32	3.8 GHz	256 MB	320 W	10.0	DDR5-6400
AMD EPYC 9355P	32	3.55 GHz	256 MB	280 W	8.8	DDR5-6400
AMD EPYC 9335	32	3 GHz	128 MB	210 W	6.6	DDR5-6400
AMD EPYC 9275F	24	4.1 GHz	256 MB	320 W	13.3	DDR5-6400
AMD EPYC 9255	24	3.2 GHz	128 MB	200 W	8.3	DDR5-6400
AMD EPYC 9175F	16	4.2 GHz	512 MB	320 W	20.0	DDR5-6400
AMD EPYC 9135	16	3.65 GHz	64 MB	200 W	12.5	DDR5-6400
AMD EPYC 9115	16	2.6 GHz	64 MB	125 W	7.8	DDR5-6400
AMD EPYC 9015	8	3.6 GHz	64 MB	125 W	15.6	DDR5-6400

Five SKUs are rated 240 W or below (9335, 9255, 9135, 9115 and 9015) and can use the Standard heat sink and Standard fans; every other part takes the Gen12 Performance Heat Sink (P81952-B21) with the Performance Fan Kit.
Even at 240 W or less, Performance fans are mandatory with the GPU chassis, any E3.S cage, 128 GB or 256 GB DIMMs or a graphics option. Six fan kits are fitted in every configuration.
HPE’s Smart Chassis starts from a maximum ambient: 30 °C is the default, and choosing a cooler room (tracking SKUs down to 18 °C) opens up higher-wattage processors and faster network cards. AOC optics need a cooler room than DAC cables.
Direct liquid cooling uses cold-plate kit P81123-B21 with six Performance fan kits; a liquid-cooled server ships only inside a complete 42U or 48U HPE Enterprise G2 rack.
Wattages are HPE’s default cTDP figures.

03 — Memory

24 DDR5 DIMM slots

Twenty-four DDR5 RDIMM slots, two on each of the processor’s 12 channels. Every kit is a DDR5-6400 part, but in this server the speed depends on how many are fitted: 5200 MT/s with one DIMM per channel (up to 12 modules) and 4000 MT/s in HPE’s matrix once 16, 20 or 24 are installed.

Capacity with every slot filled

by DIMM size

Operating speed

per HPE memory tables

Processor	1 DIMM / channel	2 DIMMs / channel
EPYC 9005 · all five kits (32–256 GB)	5200 MT/s	4000 MT/s*

* Two places in the QuickSpecs (the kit speed matrix and the 6 TB capacity line) print 4000 MT/s for fully populated channels; two others (the processor notes and the memory summary) print 4400 MT/s.
Supported counts are 1 and 2, then even steps up to 12, then 16, 20 and 24. Anything up to 12 runs at the one-per-channel speed; 16, 20 and 24 run at the two-per-channel speed.
The smallest kit is 32 GB, so the entry point is 32 GB and 24 × 256 GB gives the 6 TB ceiling; 12 × 256 GB gives 3 TB at 5200 MT/s.
No mixing of x4 with x8 modules or of 3DS with non-3DS, and no LRDIMM or persistent memory. HPE also lists VR-on-DIMM and Advanced ECC.

04 — Storage

8 drive-cage kits, up to 36 bays

Storage starts with the chassis. The SFF/EDSFF chassis takes up to three front boxes of 8 SFF cages or E3.S cages, and the two kinds can share a front; the 8LFF chassis adds a third LFF box for 12 bays; the GPU chassis keeps a single front box of up to 8 drives. HPE’s Smart Chassis tool turns every combination into a numbered config ID, and the layouts below come from those tables.

Headline layouts

front panel view

Front panel

Three 12-bay E3.S boxes with every drive direct-attached at x2 — the drive-count maximum, and at 36 × 30.72 TB the 1,105.92 TB raw figure HPE quotes.

SAS/SATANVMeSAS/SATA + NVMe

Controllers & boot

HPE MR216i-o Gen11 x16 Lanes without Cache OCP SPDM Storage Controller — HBA. Tri-Mode; occupies an OCP slot (OROC). Appears in Standard Features, the Smart Chassis 'Available options of Storage Controllers' list and the Core Options Storage Controller list.
HPE MR216i-p Gen11 x16 Lanes without Cache PCI SPDM Plug-in Storage Controller — HBA. Tri-Mode; PCIe plug-in card.
HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller — RAID, 4GB cache. Tri-Mode; OCP (OROC) slot. Cached controllers need a Smart Storage battery/capacitor (max one per server).
HPE MR408i-p Gen11 x8 Lanes 4GB Cache PCI SPDM Plug-in Storage Controller — RAID, 4GB cache. Tri-Mode; PCIe plug-in card. DOC CONTRADICTION: the Standard Features 'HPE Hardware RAID Controller Options' list names this part 'HPE MR408i-p Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller' (says OCP for a -p PCIe card); the Configuration Information and Core Options tables both print 'PCI SPDM Plug-in', which is what is recorded here.
HPE MR416i-o Gen11 x16 Lanes 8GB Cache OCP SPDM Storage Controller — RAID, 8GB cache. Tri-Mode; OCP (OROC) slot.
HPE MR416i-p Gen11 x16 Lanes 8GB Cache PCI SPDM Plug-in Storage Controller — RAID, 8GB cache. Tri-Mode; PCIe plug-in card.
HPE MR932i-p x32 Lanes PCIe Gen5 SPDM Plug-in Storage Controller — RAID. PCIe Gen5 x32-lane plug-in controller; the document does not print a cache size for it. Used in Smart Chassis configs 1-14, 1-17, 1-26, 1-29, 1-35 and GPU configs 3-15 to 3-18; needs a dedicated MR932i-p cable kit (P87898/P87901/P87902/P87903-B21 on SFF/EDSFF, P87905/P87907-B21 on GPU CTO).
HPE Smart Array E208e-p SR Gen10 (8 External Lanes/No Cache) 12G SAS PCIe Plug-in Controller — HBA. External-ports-only SAS controller. Appears in the Configuration Information 'Available options of Storage Controllers' list and in the Core Options Storage Controller list, but NOT in the Standard Features 'HPE Hardware RAID Controller Options' list.
HPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device (P78279-B21) — boot
HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device (P81160-B21) — boot
HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device (P81162-B21) — boot
HPE ProLiant Compute Gen12 NS204i-u Front Enablement Kit (P74759-B21) - mounts the NS204i-u in the front cage — boot

All 11 controllers and 5 boot options

HPE NS204i-u v2 480GB NVMe Hot Plug Boot Optimized Storage Device — Boot. x4 PCIe Gen3.0 OS boot device, 2 x M.2 NVMe SSDs with preconfigured hardware RAID1. Front (P74759-B21) or rear (P71433-B21 cable kit) mounting.
HPE NS204i-u v2 960GB NVMe Hot Plug Boot Optimized Storage Device — Boot. x4 PCIe Gen3.0 OS boot device, 2 x M.2 NVMe SSDs, hardware RAID1.
HPE NS204i-u v2 960GB NVMe SED Hot Plug Boot Optimized Storage Device — Boot. Self-encrypting variant of the NS204i-u v2 boot device.
HPE ProLiant Compute DL3XX Gen12 NS204i-u Rear Cable Kit (P71433-B21) - rear mounting — boot

SFF and E3.S boxes can share one front: configs 1-33 to 1-35 combine an 8-bay E3.S box with an 8SFF x4 cage for 16 NVMe drives.
Lanes per NVMe drive depend on the cage and cabling — x1 cages run SATA direct attach or go through a controller, and x4 cages can attach to the processor at x2 or x4.
The 2SFF x4 rear cage (P87908-B21) is offered on every chassis, cabled either for NVMe direct attach or to a controller in OCP slot B.
The NS204i-u v2 boot device (two M.2 NVMe drives in hardware RAID 1 on an x4 PCIe Gen3 link) mounts above power supply 1 or in box 2 of the front cage on the SFF/EDSFF and GPU chassis.
The GPU chassis tops out at eight drives in its single front box: an 8SFF x4 cage or four or eight E3.S bays. HPE’s Smart Chassis table and its two MR932i-p GPU cable kits label that box 2, while its other GPU cable kits call it box 1.
HPE’s standard-features controller list calls the MR408i-p an OCP card, while its order code (P74775-B21) is listed as a PCIe plug-in.

Every documented drive-cage kit

8 with drive bays

2.5-inch3.5-inchEDSFF (E1.S / E3.S)

05 — Accelerators & I/O

GPUs, PCIe and networking

GPU support depends on the chassis. The SFF/EDSFF and 8LFF chassis take single-width NVIDIA L4 cards in the rear slots — up to six by HPE’s option note, although its thermal matrix never lists more than five usable slots and rules them out with a 12 LFF front. The GPU chassis instead opens full-length x16 slots at the front for up to four L4, L40S or RTX PRO 4500 cards, or two RTX PRO 6000 Blackwell cards, each RTX PRO 6000 on its own 450 W cable from the motherboard. Up to 4 double-width at the front of the GPU chassis (RTX PRO 6000: 2); rear L4 as the ambient matrix allows.

NVIDIA L4 24GB PCIe Accelerator for HPE

single-wide

24GB · up to 6 (rear of the SFF/EDSFF and 8LFF CTO servers) or up to 4 (front of the GPU CTO server)

NVIDIA L40S 48GB PCIe Accelerator

single-wide

48GB · up to 4 (front of the GPU CTO server)

NVIDIA RTX PRO 6000 Blackwell Server Edition 96GB PCIe Accelerator for HPE

double-wide

96GB · up to 2 (front of the GPU CTO server)

NVIDIA RTX PRO 4500 Blackwell Server Edition 32GB PCIe Accelerator for HPE

double-wide

32GB · up to 4 (front of the GPU CTO server)

I/O topology

128 lanes per CPU

One SP5 processor with 128 PCIe 5.0 lanes feeds up to six x16 slots and OCP 3.0 positions at the rear and, on the SFF/EDSFF and GPU chassis, at the front.

Network adapters HPE lists

35 options

Adapter	Ports	Form
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE	4 × 1GbE	PCIe
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE	2 × 10GbE	PCIe
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE	2 × 10GbE	PCIe
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE	4 × 10/25GbE	PCIe
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Mellanox MCX631102AS-ADAT Ethernet 10/25Gb 2-port SFP28 Adapter for HPE	2 × 10/25GbE	PCIe
Intel E810-XXVDA4 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE	4 × 10/25GbE	PCIe
NVIDIA Ethernet 10/25Gb 2-port SFP28 NVMe-oF Crypto Adapter for HPE	2 × 10/25GbE	PCIe
Mellanox MCX623106AS-CDAT Ethernet 100Gb 2-port QSFP56 Adapter for HPE	2 × 100GbE	PCIe
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 Adapter for HPE	2 × 100GbE	PCIe
NVIDIA Ethernet 100Gb 2-port NVMe-oF Offload Adapter for HPE	2 × 100GbE	PCIe
Broadcom BCM57608 Ethernet 100Gb 2-port QSFP112 Adapter for HPE	2 × 100GbE	PCIe
Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE	4 × 1GbE	OCP 3.0
Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ OCP3 Adapter for HPE	2 × 10GbE	OCP 3.0
Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T OCP3 Adapter for HPE	2 × 10GbE	OCP 3.0
Broadcom BCM57414 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 OCP3 Adapter for HPE	4 × 10/25GbE	OCP 3.0
Intel E810-XXVDA2 Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Intel E810-XXVDA4 Ethernet 10/25Gb 4-port SFP28 OCP3 Adapter for HPE	4 × 10/25GbE	OCP 3.0
Mellanox MCX631432AS-ADAI Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE	2 × 10/25GbE	OCP 3.0
Intel E810-CQDA2 Ethernet 100Gb 2-port QSFP28 OCP3 Adapter for HPE	2 × 100GbE	OCP 3.0
Broadcom BCM57608 Ethernet 100Gb 2-port QSFP112 OCP3 Adapter for HPE	2 × 100GbE	OCP 3.0
HPE InfiniBand NDR200/Ethernet 200GbE 2-port QSFP112 PCIe5 x16 MCX755106AC-HEAT Adapter	2 × InfiniBand NDR200 / 200GbE	PCIe
HPE InfiniBand NDR/Ethernet 400Gb 1-port OSFP PCIe5 x16 MCX75310AAS-NEAT Generic Adapter	1 × InfiniBand NDR / 400Gb	PCIe
HPE InfiniBand NDR200/Ethernet 200Gb 1-port OSFP PCIe5 x16 MCX75310AAS-HEAT Generic Adapter	1 × InfiniBand NDR200 / 200Gb	PCIe
HPE InfiniBand XDR/Ethernet 2x400GbE 1-port OSFP PCIe6 x16 HHHL CX8 Crypto Adapter	1 × InfiniBand XDR / 2 x 400GbE	PCIe
HPE InfiniBand XDR400/Ethernet 400GbE 2-port QSFP112 PCIe6 x16 HHHL CX8 Crypto Adapter	2 × InfiniBand XDR400 / 400GbE	PCIe
HPE InfiniBand XDR PCIe Gen6 x16 Multi Host/Socket Direct Auxiliary Card with 250mm MCIO Cable Kit	0 × n/a (auxiliary card)	PCIe
HPE SN1610Q 32Gb 1-port Fibre Channel Host Bus Adapter	1 × 32Gb Fibre Channel	PCIe
HPE SN1610Q 32Gb 2-port Fibre Channel Host Bus Adapter	2 × 32Gb Fibre Channel	PCIe
HPE SN1700Q 64Gb 1-port Fibre Channel Host Bus Adapter	1 × 64Gb Fibre Channel	PCIe
HPE SN1700Q 64Gb 2-port Fibre Channel Host Bus Adapter	2 × 64Gb Fibre Channel	PCIe
HPE SN1620E 32Gb 2p FC SecureHBA	2 × 32Gb Fibre Channel	PCIe
HPE SN1720E 64Gb 2p FC SecureHBA	2 × 64Gb Fibre Channel	PCIe

Six is the ceiling on every chassis. For the GPU chassis HPE lists eight positions — slot 6 and front slots 10 and 12 by default, slots 1, 2, 3, 15 and 17 as options — so no build uses all of them; slots 4 and 5 are not listed there.
HPE’s base-configuration table says “Up to 2 OCP 3.0 slots” yet lists four positions: rear A and B, front primary and front secondary.
OCP B has no direct wiring to the processor; it needs one or two x8 enablement kits (P81908-B21), and its bandwidth follows how many are fitted.
Rear A, rear B and the front primary slot support shared-NIC and Wake-on-LAN; the front secondary slot supports Wake-on-LAN only, and it can be ordered only after the front primary kit.
The processor limits four slot groups to 112 GB/s each: 1/15 with OCP B, 2/17 with 3, 4/10 with 6, and 5/12 with OCP A.
The slot 6 riser is standard; the slot 1/2 riser kit can only be added after the slot 3 kit, and a separate kit brings slots 4 and 5.
There is no embedded LAN; the 1 GbE iLO port at the rear is dedicated to management.

06 — Power & cooling

7 power supplies, 800–3,200 W

Gen12 moves the DL345 to HPE’s M-CRPS supplies, built in 73.5 mm and 60 mm widths: an 800 W Platinum unit, Titanium units at 1000, 1500, 2400 and 3200 W, and two −48 V DC units at 1300 W and 2200 W, each needing its own lug kit.

AC−48 V DC

Every AC unit delivers less on a low-line feed. The 3200 W model gives 1600 W at 100–127 V and the 2400 W model 1200 W steady (2400 W peak); the 1500 W model gives 1000 W at 100 V or 1100 W at 110–120 V, the 1000 W model 800 W and the 800 W model 650 W at 100–120 V.
The four Titanium AC units are rated 96% efficient and are the ones HPE names for ErP Lot 9; the 800 W Platinum unit is left out of that statement.
Different supply types cannot be mixed in one server, and factory-fitted supplies ship with a 1.83–2 m cord.
Every configuration in HPE’s weight table assumes two M-CRPS supplies.

07 — Management, security & OS

Run it, secure it, choose the OS

Management

HPE iLO 7 on its own ASIC, with Intelligent Provisioning as standard
HPE Compute Ops Management — a 3-year subscription is added by default with Gen12 rack servers
Optional iLO Advanced and HPE OneView
iLO RESTful API (Redfish) · IPMI 2.0 · SNMP v3
Dedicated 1 GbE iLO port at the rear · iLO service port on a front USB-C connector
The OpenBMC line still refers to the iLO 6 transfer-of-ownership process

Security

Secure Enclave — Silicon Root of Trust 2.0
CNSA 2.0 quantum-resistant (PQC) readiness for firmware signing
Secure Standard Mode as the default security mode
TPM 2.0 embedded on the DC-SCM for global shipments; can be disabled in BIOS
UEFI Secure Boot and Secure Start · signed firmware, Secure Recovery and rollback
One-button secure erase following NIST SP 800-88
FIPS 140-3 validation and Common Criteria listed as planned, while the security overview claims adherence to FIPS 140-3
Front bezel key lock, padlock and Kensington slots · optional chassis intrusion detection
Optional HPE Trusted Supply Chain (needs the intrusion kit and iLO Advanced)

Operating systems

HPE lists certified operating systems and hypervisors in its Servers Support & Certification Matrices rather than in the QuickSpecs
UEFI Class 3 · UEFI 2.7 · Microsoft logo certifications listed

08 — Compare

How the DL345 Gen12 compares with its family

How the Gen12 DL345 lines up against the AMD ProLiant rack servers we cover from both generations. Each bar takes its figures from that model’s spec file, not from marketing copy.

This modelSiblings and successorEach value from that model’s own verified spec file · bars scale per column

DL345 Gen11 data sheet DL325 Gen12 data sheet DL325 Gen11 data sheet DL365 Gen11 data sheet DL385 Gen11 data sheet Dell PowerEdge R7715 data sheet Lenovo ThinkSystem SR655 V3 data sheet Dell PowerEdge R7615 data sheet

09 — Use cases

Five builds that suit the DL345 Gen12

Five DL345 Gen12 builds, one per chassis strength, using only parts our configurator carries for this model. Each opens ready to change; the Smart Chassis config ID, cabling and ambient setting are settled with HPE’s tables when we quote.

AI inference

Two RTX PRO 6000 inference node

A pair of 96 GB RTX PRO 6000 Blackwell boards (192 GB between them) sits in the front of the GPU chassis, each fed by its own 450 W motherboard cable. Twelve DIMMs keep memory at the one-per-channel 5200 MT/s, and a 4-bay E3.S box is one of HPE’s GPU storage options (config 3-9).

1 × AMD EPYC 9455P — 48 cores @ 3.15 GHz, 300 W
2 × NVIDIA RTX PRO 6000 Blackwell Server Edition 96 GB, double-width, front slots
12 × 64 GB DDR5 RDIMM — 768 GB at 5200 MT/s
4 × 7.68 TB E3.S NVMe, x4 direct attach
NS204i-u v2 mirrored M.2 boot
Broadcom BCM57608 2 × 100GbE QSFP112 OCP 3.0
2 × 3200 W M-CRPS Titanium (1600 W each at 100–127 V)
Red Hat Enterprise Linux 9, 3-year subscription

HPE allows at most two RTX PRO 6000 per server, one P89898-B21 cable each, and its thermal matrix rates the pair at 30 °C. The GPU chassis always takes the Performance heat sink and fans, is 83.71 cm deep and stops at eight drives.

Open this build in the configurator →

Graphics & VDI

Four-GPU visual computing host

Four double-width RTX PRO 4500 Blackwell cards (128 GB of GPU memory in total) fill the front slots, and HPE’s matrix rates four of them at 35 °C. Eight U.3 NVMe drives at x4 direct attach match GPU config 3-4, and 1,152 GB of DDR5 backs the desktops or render jobs.

1 × AMD EPYC 9355P — 32 cores @ 3.55 GHz, 280 W
4 × NVIDIA RTX PRO 4500 Blackwell Server Edition 32 GB, double-width
12 × 96 GB DDR5 RDIMM — 1,152 GB at 5200 MT/s
8 × 3.84 TB NVMe U.3 on an 8SFF x4 cage — 30.72 TB raw
NS204i-u v2 mirrored M.2 boot
Intel E810-XXVDA4 4 × 25GbE SFP28 OCP 3.0
2 × 2400 W M-CRPS Titanium
Windows Server 2025 Datacenter

Each pair of RTX PRO 4500 cards shares one power cable kit (P75110-B21), and four front cards need the 4-GPU enablement kit for slots 15 and 17. HPE’s only 8SFF x4 NVMe direct-attach cable kit for this chassis is named for two GPUs (P84346-B21), so the four-GPU cabling is confirmed at quotation. The 280 W processor and the GPU chassis both call for Performance cooling.

Open this build in the configurator →

Virtualisation

192-core, 6 TB consolidation host

An EPYC 9965 gives 192 cores on one socket, and 24 × 256 GB 3DS modules take memory to the 6 TB ceiling — the most cores and memory this single-socket server takes. Eight NVMe drives on an x4 cage hold local datastores.

1 × AMD EPYC 9965 — 192 cores @ 2.25 GHz, 500 W
24 × 256 GB 3DS RDIMM — 6 TB at two DIMMs per channel
8 × 7.68 TB NVMe U.3 on an 8SFF x4 cage — 61.44 TB raw
NS204i-u v2 mirrored M.2 boot
Broadcom BCM57504 4 × 25GbE SFP28 OCP 3.0
2 × 2400 W M-CRPS Titanium
Windows Server 2025 Datacenter

At 24 DIMMs memory runs at the two-per-channel speed (4000 MT/s in HPE’s matrix, 4400 MT/s in two notes). The 500 W processor needs the Performance heat sink and fans, and HPE’s network thermal matrices withdraw several adapters and slots at 500 W, so we check the NIC against them.

Open this build in the configurator →

Backup & file

12-bay LFF repository with NVMe cache

The 8LFF chassis with its third box holds 12 × 24 TB drives behind an OCP controller (config 2-6) — the 288 TB printed in HPE’s maximum-storage table, although 26 TB LFF drives are also on its list. The rear 2SFF cage adds two NVMe drives cabled straight to the processor for a cache or metadata tier, and a 200 W processor keeps Standard cooling.

1 × AMD EPYC 9135 — 16 cores @ 3.65 GHz, 200 W
12 × 24 TB 7.2K SATA LFF HDD — 288 TB raw
2 × 3.84 TB NVMe U.3 in the rear 2SFF cage
HPE MR416i-o Gen11 OCP controller, 8 GB cache
12 × 32 GB DDR5 RDIMM — 384 GB
NS204i-u v2 mirrored M.2 boot
Broadcom BCM57414 2 × 25GbE SFP28 OCP 3.0
2 × 1000 W M-CRPS Titanium
Windows Server 2025 Standard

The rear cage needs its NVMe direct-attach cable kit (P87909-B21). Config 2-6 cables the MR416i-o to OCP slot A and the 8LFF chassis has no front OCP, so the network card goes in OCP slot B, which needs at least one P81908-B21 enablement kit.

Open this build in the configurator →

Databases

High-clock NVMe database server

The EPYC 9175F runs just 16 cores from a 4.2 GHz base, the highest base clock on HPE’s list, with 512 MB of cache. Eight U.3 NVMe drives on one 8SFF x4 cage attach straight to the processor at x4 each, HPE’s config 1-11, and twelve DIMMs hold the 5200 MT/s speed.

1 × AMD EPYC 9175F — 16 cores @ 4.2 GHz, 320 W
12 × 64 GB DDR5 RDIMM — 768 GB at 5200 MT/s
8 × 3.84 TB NVMe U.3 on an 8SFF x4 cage, x4 direct attach — 30.72 TB raw
NS204i-u v2 mirrored M.2 boot
Broadcom BCM57414 2 × 25GbE SFP28 OCP 3.0
2 × 1500 W M-CRPS Titanium (1100 W each at 110–120 V)
Windows Server 2025 Standard

At 320 W the 9175F needs the Performance heat sink and fans. Adding DIMMs beyond 12 drops memory to the two-per-channel speed.

Open this build in the configurator →

10 — Refurbished alternatives

When a refurbished ProLiant makes more sense

Not every single-socket AMD project needs EPYC 9005, 24 DDR5 slots or front GPUs. These re-certified ProLiant models from our refurbished configurator do comparable work on DDR4 and PCIe 4.0 or earlier.

Gen10 Plus · re-certified

HPE ProLiant DL385 Gen10 Plus

2U · one or two EPYC 7002/7003
Up to 128 cores in total
DDR4-3200 · 32 slots · up to 8 TB
24 SFF or 12 LFF · iLO 5

Matches the Gen12’s 2U footprint and memory reach on older silicon, for storage or virtualisation work that does not need PCIe Gen5.

Configure a refurbished DL385 Gen10 Plus →

Gen10 Plus · re-certified

HPE ProLiant DL325 Gen10 Plus

1U · single EPYC 7002/7003
Up to 64 cores
16 DDR4 slots · up to 4 TB
128 PCIe 4.0 lanes · iLO 5

A single-socket AMD alternative for compute nodes that fit in 1U and ten SFF bays.

Configure a refurbished DL325 Gen10 Plus →

Gen10 · re-certified

HPE ProLiant DL325 Gen10

1U · single EPYC 7001
Up to 32 cores
16 DDR4 slots · up to 2 TB
10 SFF / NVMe · iLO 5

The oldest single-socket option here, for light virtualisation or edge services that 32 EPYC 7001 cores can handle.

Configure a refurbished DL325 Gen10 →

Refurbished HPE ProLiant servers Refurbished HPE configurator New vs refurbished cost calculator

11 — Full specifications

HPE ProLiant Compute DL345 Gen12 specifications

Chassis & cooling

Form factor	2U rack · one processor
CTO chassis	SFF/EDSFF (P81948-B21) · 8LFF (P81947-B21) · GPU (P81949-B21)
Dimensions (H × W × D)	8.75 × 44.8 × 63.55 cm (SFF/EDSFF) · 65.61 cm deep (8LFF) · 83.71 cm deep (GPU)
Maximum weight	22.6 kg (36 E3.S) · 26.62 kg (12 LFF) · 29.59 kg (GPU chassis, 4 double-width GPUs)
Fans	Six fan kits in every configuration · Standard or Performance · redundant
Liquid cooling	Optional cold plate (P81123-B21); ships only inside a whole HPE rack

Processor

Sockets	One · SP5 (6096-pin LGA)
Family	5th Gen AMD EPYC 9005 only · 23 SKUs
Cores	8 to 192
Default cTDP	125 W to 500 W
PCIe lanes	128 × PCIe 5.0
Chipset	None — system-on-chip design

Memory

Slots	24 DDR5 RDIMM · 12 channels × 2 DIMMs
DIMM sizes	32, 64, 96 and 128 GB · 256 GB 3DS
Speed	5200 MT/s at 1 DPC · 4000 MT/s at 2 DPC (4400 MT/s in two notes)
Maximum	6.0 TB (24 × 256 GB) · 3.0 TB at 1 DPC (12 × 256 GB)
Population	1, 2, 4, 6, 8, 10, 12, 16, 20 or 24 DIMMs
Not supported	LRDIMM, persistent memory, 4800 and 5600 MT/s DIMMs

Storage

SFF/EDSFF chassis	Up to 24 SFF (x1 or x4 U.3 cages) or 36 E3.S · SFF and E3.S boxes can be mixed
8LFF chassis	8 LFF standard · 12 LFF with a third box · or 8 LFF + 2 SFF
GPU chassis	Up to 8 SFF or 8 E3.S in one front box
Rear	Optional 2SFF x4 tri-mode cage on every chassis
Controllers	MR216i-o/-p, MR408i-o/-p, MR416i-o/-p, MR932i-p · E208e-p for external storage
Boot	NS204i-u v2: 2 × M.2 NVMe, hardware RAID 1 · front or rear mounting
Optical	Via the Universal Media Bay (SFF/EDSFF) or LFF ODD kit (8LFF)

Expansion & networking

PCIe slots	Up to 6 × PCIe 5.0 x16, full height, on every chassis (slot 6 standard)
GPU chassis	Front FHFL slots 10 and 12 standard, 15 and 17 optional, within the six
OCP 3.0	Rear A (x16) and B (x8/x16) · front primary and secondary (x16) · “up to 2” per base table
Embedded LAN	None — OCP 3.0 or stand-up Ethernet and InfiniBand adapters
Fibre Channel	32 Gb and 64 Gb HBAs, including SN1620E and SN1720E SecureHBAs

Accelerators

Rear (SFF/EDSFF, 8LFF)	NVIDIA L4 24 GB, single-width · “Max = 6” per option note, at most 5 slots in the thermal matrix, none with a 12 LFF front
Front (GPU chassis)	Up to 4 × L4, L40S 48 GB or RTX PRO 4500 32 GB · up to 2 × RTX PRO 6000 96 GB

Power

Supplies	M-CRPS hot-plug · no mixing of types · HPE’s weight table assumes two
AC	800 W Platinum · 1000, 1500, 2400 and 3200 W Titanium
DC	1300 W and 2200 W, −48 V DC (lug kits required)

Ports & video

Front	1 × USB 3.2 Gen 1 · iLO service port (USB-C) · optional DisplayPort and USB 2.0 via media bay
Rear	2 × USB 3.2 Gen 1 · VGA · 1 GbE iLO · optional serial
Internal	1 × USB 3.2 Gen 1
Video	1920 × 1200 at 60 Hz, 16 MB video memory

Environment & warranty

Operating	10–35 °C at sea level · 5–45 °C extended for approved configurations · ASHRAE A3/A4
Acoustics (LWA,m)	4.7 B entry · 5.8 B performance configuration (idle and operating)
Warranty	3 years parts, labour and onsite, next business day

12 — FAQ

DL345 Gen12 questions, answered from the documentation

What is the maximum memory of the HPE ProLiant DL345 Gen12?

6 TB, with a 256 GB 3DS module in all 24 slots — two per channel. At that population HPE’s kit matrix gives 4000 MT/s, although two notes in the same document say 4400 MT/s. Keeping to 12 DIMMs, one per channel, holds 5200 MT/s and tops out at 3 TB.

Which processors does the DL345 Gen12 support?

Twenty-three single AMD EPYC 9005 processors spanning 8–192 cores and 125–500 W default cTDP; no 4th Gen EPYC part is offered. The 192-core 9965 and 128-core 9755 are the 500 W parts, and the 16-core 9175F has the highest base clock at 4.2 GHz.

How many drives does the DL345 Gen12 hold?

Up to 36 E3.S drives or 24 SFF drives in the SFF/EDSFF chassis, 12 LFF (or 8 LFF plus 2 SFF) in the 8LFF chassis, and 8 drives in the GPU chassis. A 2SFF rear cage is available on all three, and the NS204i-u boot device adds a mirrored M.2 pair.

How many GPUs does the DL345 Gen12 support?

In the GPU chassis, up to four front-mounted L4, L40S or RTX PRO 4500 cards, or two RTX PRO 6000 Blackwell cards on 450 W cables. The SFF/EDSFF and 8LFF chassis take single-width NVIDIA L4 cards in the rear slots: HPE’s option note allows six, but its thermal matrix lists at most five usable slots at 25 °C, varying with processor wattage and front storage, and none with a 12 LFF front.

How many PCIe and OCP slots does the DL345 Gen12 have?

Up to six PCIe 5.0 x16 full-height slots on every chassis. On the GPU chassis up to four of those six are the front full-length slots 10, 12, 15 and 17. OCP 3.0 positions sit at the rear (A at x16, B at x8 or x16) and, on the SFF/EDSFF and GPU chassis, at the front; HPE’s base table counts up to two OCP slots.

What power supplies are available for the DL345 Gen12?

Five M-CRPS AC units — 800 W Platinum and 1000, 1500, 2400 and 3200 W Titanium — plus 1300 W and 2200 W −48 V DC units. Every AC unit gives less on a low-line feed: the 3200 W supply delivers 1600 W at 100–127 V and the 800 W supply 650 W at 100–120 V. Supplies of different types cannot be mixed.

How big and heavy is the DL345 Gen12?

All three chassis share an 8.75 × 44.8 cm face (height × width); depths are 63.55 cm for SFF/EDSFF, 65.61 cm for 8LFF and 83.71 cm for the GPU chassis. HPE’s maximum weights are 22.6 kg with 36 E3.S drives, 26.62 kg with 12 LFF drives and 29.59 kg for a GPU chassis with four double-width cards.

What changed from the DL345 Gen11 to the Gen12?

Gen11 accepted 4th and 5th Gen EPYC with 12 DIMM slots (3 TB), iLO 6 and Flex Slot supplies up to 1800–2200 W, reached 34 SFF or 20 LFF with mid-tray and rear cages, and its GPU chassis took four single-width or two double-width cards (the current Gen11 list shows only the L4). Gen12 takes EPYC 9005 only, 24 DIMM slots (6 TB), iLO 7 and M-CRPS supplies to 3200 W, drops the mid tray, raises the front double-width limit to four and adds front OCP slots.

Can the DL345 Gen12 be liquid-cooled?

Yes. HPE offers a direct liquid cooling cold-plate kit (P81123-B21) with a quick-disconnect tube set and six Performance fan kits. A liquid-cooled DL345 Gen12 ships only as part of a complete 42U or 48U 800 × 1200 mm HPE Enterprise G2 rack.

Is the HPE ProLiant Compute DL345 Gen12 end of life?

No. HPE first published its QuickSpecs on 7 July 2025, and version 12 (3 August 2026) is still revising drive options. The document carries no end-of-sale or end-of-support date, and the standard warranty covers parts, labour and onsite visits for three years with next-business-day response. Our end-of-life checker is where any future HPE dates will appear.

Sources & verification

Where these figures come from

HPE ProLiant Compute DL345 Gen12 QuickSpecs (Version 12 - 03-Aug-2026; header prints Version 12 - August 3, 2026) — Overview, platform information, processor notes, memory, expansion slots, storage controllers, maximum storage, interfaces, M-CRPS supplies, security, warranty, Step 1 CTO tables, Smart Chassis and ambient tracking, processor and memory options, storage configurations and cable kits, drive lists, risers and OCP kits, graphics options and thermal matrices, air and liquid cooling, power supplies, technical specifications and summary of changes.
HPE ProLiant DL345 Gen11 QuickSpecs (Version 40 - August 3, 2026) — Gen11 limits used in the generational FAQ answer.
HPE product image library (assets.ext.hpe.com) — Front (s00014907) and internal (s00014910) renders.

Specifications are extracted from HPE’s published documents and independently re-checked line by line. Configurations are quote-based; availability and exact options are confirmed at quotation. Last reviewed 2026-09-11.

Get a quote for the HPE ProLiant Compute DL345 Gen12

Tell us the workload and we’ll spec and price it — or build it in the configurator first.

Business enquiries only — please use your company email. Gmail, Hotmail and other personal addresses are not accepted.

Delivery country (optional)

We only ship hardware to the countries in the dropdown. Software and maintenance services are global.

Enquiring about: HPE ProLiant Compute DL345 Gen12

Full Name *

Email *

Company

Quantity Required

Additional Notes

Response within 4 business hours · No obligation

Quote for

HPE ProLiant Compute DL345 Gen12

0800 987 4111

The DL345 Gen12 at a glance

Strengths

Watch-outs

23 supported processors, mapped

Processor landscape — cores × TDP

Processor explorer

24 DDR5 DIMM slots

Capacity with every slot filled

Operating speed

8 drive-cage kits, up to 36 bays

Headline layouts

Controllers & boot

Every documented drive-cage kit

GPUs, PCIe and networking

NVIDIA L4 24GB PCIe Accelerator for HPE

NVIDIA L40S 48GB PCIe Accelerator

NVIDIA RTX PRO 6000 Blackwell Server Edition 96GB PCIe Accelerator for HPE

NVIDIA RTX PRO 4500 Blackwell Server Edition 32GB PCIe Accelerator for HPE

I/O topology

Network adapters HPE lists

7 power supplies, 800–3,200 W

Run it, secure it, choose the OS

Management

Security

Operating systems

How the DL345 Gen12 compares with its family

Five builds that suit the DL345 Gen12

Two RTX PRO 6000 inference node

Four-GPU visual computing host

192-core, 6 TB consolidation host

12-bay LFF repository with NVMe cache

High-clock NVMe database server

When a refurbished ProLiant makes more sense

HPE ProLiant DL385 Gen10 Plus

HPE ProLiant DL325 Gen10 Plus

HPE ProLiant DL325 Gen10

HPE ProLiant Compute DL345 Gen12 specifications

Chassis & cooling

Processor

Memory

Storage

Expansion & networking

Accelerators

Power

Ports & video

Environment & warranty

DL345 Gen12 questions, answered from the documentation

Where these figures come from

Buy & configure

Guides & family

Plan the deployment

Support & lifecycle

Get a quote for the HPE ProLiant Compute DL345 Gen12

Talk to a UK specialist